The expression of pancreatic endocrine markers in centroacinar cells of the normal and regenerating rat pancreas: Their possible transformation to endocrine cells

Archives of Histology and Cytology

Volumn 66, Issue 4, 2003, Pages 347-358

  Suzuki, Tetsutaro ^a   Kadoya, Yuichi ^a   Sato, Yuichi ^b   Handa, Kimiya ^a   Takahashi, Tsuyoshi ^a   Kakita, Akira ^a   Yamashina, Shohei ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; GLUCAGON; INSULIN; MESSENGER RNA;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL NUCLEUS; CENTROACINAR CELL; CONTROLLED STUDY; CYTOPLASM; GENE; GENE EXPRESSION; HORMONE SYNTHESIS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; NONHUMAN; PANCREAS ISLET; PANCREAS RESECTION; PDX 1 GENE; RAT; STEM CELL; TISSUE REGENERATION;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CELL NUCLEUS; CYTOPLASM; ENDOCRINE SYSTEM; GLUCAGON; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INSULIN; MALE; PANCREAS; RATS; RATS, WISTAR; REGENERATION; TRANS-ACTIVATORS;

EID: 0347418052     PISSN: 09149465     EISSN: None     Source Type: Journal    
DOI: 10.1679/aohc.66.347     Document Type: Article

References (41)

1. Bertelli E, Regoli M, Orazioli D, Bendayan M: Association between islet of Langerhans and pancreatic ductal system in adult rat. Where endocrine and exocrine meet together? Diabetologia 44: 575-584 (2001).
2. Bonner-Weir S, Sharma A: Pancreatic stem cells. J Pathol 197: 519-526 (2002).
3. Bonner-Weir S, Taneja M, Weir GC, Tatarkiewicz K, Song KH, Sharma A, O'Neil JJ: In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA 97: 7999-8004 (2000).
4. Bouwens L, Kloppel G: Islet cell neogenesis in the pancreas. Virchows Arch 427: 553-560 (1996).
5. Cordell B, Bell G, Tischer E, DeNoto FM, Ullrich A, Pictet R, Rutter WJ, Goodman HM: Isolation and characterization of cloned rat insulin gene. Cell 18: 533-543 (1979).
6. Drucker DJ: Minireview: The glucagon-like peptides. Endocrinology 142: 521-527 (2001).
7. Ekholm R, Edlund Y: Ultrastructure of the human exocrine pancreas. Ultrastructure Res 2: 453-481 (1959).
8. Gasslander T, Smeds S, Blomqwist L, Ihse I: Proliferative response of different exocrine pancreatic cell types to hormonal stimuli. Scand J Gastroenterol 25: 1103-1110 (1990).
9. Gasslander T, Ihse I, Smeds S: The importance of the centroacinar region in cerulein-induced mouse pancreatic growth. Scand J Gastroenterol 27: 564-570 (1992).
10. Guz Y, Montminy MR, Stein R, Leonard J, Gamer LW, Wright CVE, Teitelman G: Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121: 11-18 (1995).
11. Hayashi K, Takahashi T, Kakita A, Yamashina S: Regional differences in the cellular proliferation activity of the regenerating rat pancreas after partial pancreatectomy. Arch Histol Cytol 62: 337-346 (1999).
12. Hayashi KY, Tamaki H, Handa K, Takahashi T, Kakita A, Yamashina S: Differentiation and proliferation of endocrine cells in the regenerating rat pancreas after 90% pancreatectomy. Arch Histol Cytol 66: 163-174 (2003).
13. Hasegawa H, Mizuhira V, Notoya M: Microwave-stimulated fixation and histochemical application to biological specimens. Acta Histochem Cytochem 33: 319-340 (2000).
14. Heinrich G, Gros P, Lund PK, Bentley RC, Habener JF: Pre-proglucagon messenger ribonucleic acid: Nucleotide and encoded amino acid sequences of the rat pancreatic complementary deoxyribonucleic acid. Endocrinology 115: 2176-2181 (1984).
15. Kerstens HM, Poddighe PJ, Hanselaar AG: A novel in situ hybridization signal amplification method based on the deposition of biotinylated tyramine. J Histochem Cytochem 43: 347-352 (1995).
16. Klimstra DS: Pancreas In: Histology for pathologist (Sternberg SS ed.) 2nd ed. Lippincott-Raven Publishers, Philadelphia, 1997 (p. 613-647).
17. Kodama T: A light and electron microscopic study on the pancreatic ductal system. Acta Pathol Jpn 33: 297-321 (1983).
18. Lehv M, Fitzgerald PJ: Pancreatic acinar cell regeneration. IV. Regeneration after surgical resection. Am J Pathol 53: 513-535 (1968).
19. Leong AS-Y, Milios J: An assessment of the efficacy of the microwave antigen-retrieval procedure on a range of tissue antigens. Appl Immunohistochem 1: 267-274 (1993).
20. Mckinnon CM, Docherty K: Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity an function. Diabetologia 44: 1203-1214 (2001).
21. Oertel JE: The pancreas. Nonneoplastic alterations. Am J Surg Pathol 13 (Supple 1): 50-65 (1989).
22. Ohlsson H, Karlsson K, Edlund T: IPF-1, a homeodomain-containing transactivator of the insulin gene. EMBO J 12: 4251-4259 (1993).
23. Oster A, Jensen J, Serup P, Galante P, Madsen OD, Larsson LI: Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1). J Histochem Cytochem 46: 707-715 (1998).
24. Pang K, Mukonoweshuro C, Wong GG: Beta cells arise from glucose transporter type 2 (Glut-2)-expressing epithelial cells of the developing rat pancreas. Proc Natl Acad Sci USA 91: 9559-9563 (1994).
25. Petres J, Jurgensen A, Kloppel G: Ontogeny, differentiation and growth of the endocrine pancreas. Virchows Arch 436: 527-538 (2000).
26. Pictet R, Rutter WJ: Development of the embryonic endocrine pancreas. In: Handbook of physiology, Section 7, Vol. 1 (Steiner DF and Frenkel N ed), American Physiological Society, Washington DC, 1972 (p. 25-66).
27. Pour PM: Mechanism of pseudoductular (tubular) formation during pancreatic carcinogenesis in the hamster model. An electron-microscopic and immunohistochemical study. Am J Pathol 130: 335-344 (1988).
28. Pour PM: Pancreatic centroacinar cells. The regulator of both exocrine and endocrine function. Int J Pancreatol 15: 51-64 (1994).
29. Richards C, Fitzgerald PJ, Carol B, Rosenstock L, Lipkin L: Segmental division of the rat pancreas for experimental procedures. Lab Invest 13: 1303-1321 (1964).
30. Rosenberg L: In vivo cell transformation: neogenesis of beta cells from pancreatic ductal cells. Cell Transplant 4: 371-383 (1995).
31. Scow RO: "Total" pancreatectomy in the rat: Operation, effects, and postoperative care. Endocrinology 60: 359-367 (1957).
32. Sharma A, Zangen DH, Reitz P, Taneja M, Lissauer ME, Miller CP, Weir GC, Habener JF, Bonner-Weir S: The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes 48: 507-513 (1999).
33. Slack JMW: Developmental biology of the pancreas. Development 121: 1569-1580 (1995).
34. Stein S, Fritsch R, Lemaire L, Kessel M: Checklist: vertebrate homeobox genes. Mech Dev 55: 91-108 (1996).
35. Teitelman G: Cellular and molecular analysis of pancreatic islet cell linage and differentiation. Recent Prog Horm Res 47: 259-297 (1991).
36. Teitelman G, Alpert S, Polak JM, Martinez A, Hanahan D: Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 118: 1031-1039 (1993).
37. Toshkov I, Kirev T, Bannasch P: Virus-induced pancreatic cancer in guinea fowl: An electron-microscopical study. Int J Pancreatol 10: 51-64 (1991).
38. van Gijlswijk RP, Wiegant J, Raap AK, Tanke HJ: Improved localization of fluorescent tyramides for fluorescence in situ hybridization using dextran sulfate and polyvinyl alcohol. J Histochem Cytochem 44: 389-392 (1996).
39. Wang RN, Kloppel G, Bouwens L: Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats. Diabetologia 38: 1405-1411 (1995).
40. Yamashina S, Katsumata O, Sekine R: Evaluation of microwave irradiation in immunohistochemical reactions. Acta Histochem Cytochem 23: 553-562 (1990).
41. Yang H, Wanner IB, Roper SD, Chaudhari N: An optimized method for in situ hybridization with signal amplification that allows the detection of rare mRNAs. J Histochem Cytochem 47: 431-445 (1999).