Optimal selection of sib pairs from random samples for linkage analysis of a QTL using the EDAC test

Behavior Genetics

Volumn 28, Issue 3, 1998, Pages 197-206

  Dolan, Conor V ^a   Boomsma, Dorret I ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

EDAC test; Linkage analysis; Quantitative trait locus (QTL); Random samples; Sib pair selection; Sib pairs

Indexed keywords

ALLELE; ANALYTIC METHOD; ARTICLE; BEHAVIOR GENETICS; GENE ACTIVITY; GENE FREQUENCY; GENE LOCUS; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC SELECTION; HUMAN; QUANTITATIVE TRAIT; SAMPLING; SCORING SYSTEM; SIBLING;

ALLELES; COMPUTER SIMULATION; GENETIC MARKERS; HUMANS; LINKAGE (GENETICS); MODELS, GENETIC; NUCLEAR FAMILY; PATIENT SELECTION; PHENOTYPE; PROBABILITY; QUANTITATIVE TRAIT, HERITABLE; RESEARCH DESIGN; SAMPLE SIZE; SAMPLING STUDIES;

EID: 0031865338     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021423214032     Document Type: Article

References (13)

1. Blackwelder, W. C., and Elston, R. C. (1985). A comparison of sib pair linkage tests for disease susceptibility loci. Genet. Epidemiol. 2:85-97.
2. Boomsma, D. I. (1996). Using multivariate genetic modeling to detect pleiotropic quantitative trait loci. Behav. Genet. 26:161-166.
3. Boomsma, D. I., and Dolan, C. V. (1998). A comparison of power to detect a QTL in sib pair data using multivariate phenotypes, mean phenotypes, and factor-scores (submitted for publication).
4. Cardon, L. R., and Fulker, D. W. (1994). The power of interval mapping of quantitative trait loci, using selected sib pairs. Am. J. Hum. Genet. 55:825-833.
5. Carey, G., and Williamson, J. A. (1991). Linkage analysis of quantitative traits: increased power by using selected samples. American Journal of Human Genetics, 49, 786-796.
6. Eaves, L., and Meyer, J. (1994). Locating human quantitative trait loci: Guidelines for the selection of sibling pairs for genotyping. Behav. Genet. 24:443-455.
7. Eaves, L. J., Neale, M. C., and Maes, H. (1996). Multivariate multipoint linkage analysis of quantitative trait loci. Behav. Genet. 26:519-525.
8. Fulker, D. W., and Cherny, S. S. (1996). An improved multipoint sib pair analysis of quantitative traits. Behav. Genet. 26:527-532.
9. Gu, C., Todorov, A., and Rao, D. C. (1996). Combining extremely concordant sib pairs with extremely discordant sib pairs provides a cost effective way to linkage analysis of quantitative trait loci. Genet. Epidemiol. 13:513-533.
10. Haseman, J. K., and Elston, R. C. (1972). The investigation of linkage between a quantitative trait and a marker locus. Behav. Genet. 3:3-19.
11. Risch, N. J., and Zhang, H. (1996). Mapping quantitative trait loci with extreme discordant sib pairs: Sampling considerations. Am. J. Hum. Genet. 58:836-843.
12. Risch, N. J., and Zhang, H. (1995). Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 268:1584-1589.
13. Schervish, M. J. (1984). Multivariate normal probability with error bound. Appl. Stat. 33:81-94.