Prothrombotic disorders in uremic type-1 diabetics undergoing simultaneous pancreas and kidney transplantation

Transplantation

Volumn 76, Issue 12, 2003, Pages 1691-1695

  Wullstein, Christoph ^a   Woeste, Guido ^a   Zapletal, Christina ^a   Trobisch, Heiner ^b   Bechstein, Wolf O ^a,c  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b Institut für Laboratoriumsmedizin   (Germany)

^c UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; ANTITHROMBIN; BLOOD CLOTTING FACTOR 5 LEIDEN; CARDIOLIPIN ANTIBODY; CREATININE; HEMOGLOBIN A1C; HOMOCYSTEINE; LOW MOLECULAR WEIGHT HEPARIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; PHOSPHOLIPID ANTIBODY; PROTEIN C; PROTEIN S; PROTHROMBIN; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY; TRIACYLGLYCEROL LIPASE;

ANTIPHOSPHOLIPID SYNDROME; ARTICLE; GENE MUTATION; GRAFT REJECTION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY TRANSPLANTATION; LAPAROTOMY; MAJOR CLINICAL STUDY; PANCREAS FUNCTION; PANCREAS TRANSPLANTATION; PANCREATITIS; PRIORITY JOURNAL; THROMBOSIS; UREMIA;

AMINO ACID SUBSTITUTION; ANTIPHOSPHOLIPID SYNDROME; CREATININE; DIABETES MELLITUS, TYPE 1; DIABETIC RETINOPATHY; FACTOR V; FOLLOW-UP STUDIES; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; KIDNEY TRANSPLANTATION; MUTATION; MUTATION, MISSENSE; PANCREAS TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS; PROTHROMBIN; RETROSPECTIVE STUDIES; THROMBOSIS; TIME FACTORS;

EID: 0347363458     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000091119.03828.17     Document Type: Article

References (28)

1. Troppmann C, Gruessner AC, Benedetti E, et al. Vascular graft thrombosis after pancreatic transplantation: univariate and multivariate operative and nonoperative risk factor analysis. J Am Coll Surg 1996; 182: 285.
2. Fischereder M, Goehring P, Schneeberger H, et al. Early loss of renal transplants in patients with thrombophilia. Transplantation 1998; 65: 936.
3. Vaidya S, Wang CC, Gugliuzza C, et al. Antiphospholipid antibody syndrome and posttransplant renal thrombosis. Transpl Proc 1999; 31: 230.
4. Vaidya S, Sellers R, Kimball P, et al. Frequency, potential risk and therapeutic intervention in end stage renal disease patients with antiphospholipid antibody syndrome: a multicenter study. Transplantation 2000; 69: 1348.
5. Levine JS, Branch DW, Rauch J. The antiphospholipid syndrome. N Engl J Med 2002; 346: 752.
6. Bertoli SV, di Belgiojoso GB, Trezzi M, et al. Reduced blood levels of coagulation inhibitors in chronic hemodialysis compared with CAPD. Adv Perit Dial 1995; 11: 127.
7. Demichelli M, Contino L, Iberti M, et al. Protein C and protein S levels in uremic patients before and after dialysis. Thromb Res 1992; 68: 451.
8. Seligsohn U, Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med 2001; 344: 1222.
9. Den Heijer M, Koster T, Blom HJ, et al. Hyperhomocystinemia as a risk factor for deep-vein thrombosis. N Engl J Med 1996; 334: 759.
10. Dicker-Brown A, Fonseca VA, Fink LM, et al. The effect of glucose and insulin on the activity of methylene tetrahydrofolate reductase and cystathionine-beta-synthase: studies in hepatocytes. Atherosclerosis 2001; 158: 297.
11. Koulouridis E, Tzilianos M, Katsarou A, et al. Homocysteine and C-reactive protein levels in haemodialysed patients. Int Urol Nephrol 2001; 33: 207.
12. Irish A. Renal allograft thrombosis: can thrombophilia explain the inexplicable? Nephrol Dial Transplant 1999; 14: 2297-.
13. Ducloux D, Pellet E, Fournier V, et al. Prevalence and clinical significance of antiphospholipid antibodies in renal transplant recipients. Transplantation 1999; 67: 90.
14. Wagenknecht DR, Becker DG, LeFor WM, et al. Antiphospholipid antibodies are a risk factor for early renal allograft failure. Transplantation 1999; 68: 241.
15. Ekberg H, Svensson PJ, Simanaitis M, et al. Factor V R506Q mutation (activated protein C resistance) is an additional risk factor for early renal graft loss associated with acute vascular rejection. Transplantation 2000; 69: 1577.
16. Oh J, Schaefer F, Veldmann A, et al. Heterozygous prothrombin gene mutation: a new risk factor for early renal allograft thrombosis. Transplantation 1999; 68: 575.
17. De Stefano V, Martinelli I, Mannucci PM, et al. The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V leiden and the G20210A prothrombin mutation. N Engl J Med 1999; 341: 801.
18. Juulk K, Tybjaerg-Hansen A, Steffensen R, et al. Factor V Leiden: the Copenhagen city heart study and 2 metaanalyses. Blood 2002; 100: 3.
19. Svensson PJ, Zoller B, Mattiasson I, et al. The factor VR506Q mutation causing APC resistance is highly prevalent amongst unselected outpatients with clinically suspected deep venous thrombosis. J Intern Med 1997; 241: 379.
20. Marcucci R, Fedi S, Brunelli T, et al. High cysteine levels in renal transplant recipients: relationship with hyperhomocystinemia and 5, 10-MTHFR polymorphism. Transplantation 2001; 746.
21. Hagen W, Fodinger M, Heinz G, et al. Effect of MTHFR genotype and hyperhomocystinemia on patient and graft survival in kidney transplant recipients. Kidney Int 2001; 78: S253.
22. Couturaud F, Oger E, Abalain JH, et al. Methylenetetrahydrofolate reductase C677T genotype and venous thromboembolic disease. Respiration 2000; 67: 657.
23. Hopt UT, Buesing M, Schareck W, et al. Prevention of early postoperative graft thrombosis in pancreatic transplantation. Transplant Proc 1993; 25: 207.
24. Ciancio G, Cespedes M, Olson L, et al. Partial venous thrombosis of the pancreatic allografts after simultaneous pancreas- kidney transplantation. Clin Transplant 2000; 14: 464.
25. Benz S, Bergt S, Obermaier R, et al. Impairment of microcirculation in the early reperfusion period predicts the degree of graft pancreatitis in clinical pancreas transplantation. Transplantation 2001; 71: 759.
26. Benz S, Wiessner R, Obermaier R, et al. Microcirculatory events in Ischemia/reperfusion of the pancreas defined by continuous tissue oxymetry. Transpl Int 2002; 15: 173.
27. MacMillan N, Fernandez-Cruz L, Ricart MJ, et al. Venous graft thrombosis in clinical pancreas transplantation: options for a rescue treatment. Transplant Proc 1998; 30: 425.
28. Drachenberg CA, Papadimitriou JC, Farney A, et al. Pancreas transplantation: the histologic morphology of graft loss and clinical correlations. Transplantation 2001; 71: 1784.