Multiple States of Stalled T7 RNA Polymerase at DNA Lesions Generated by Platinum Anticancer Agents

Journal of Biological Chemistry

Volumn 278, Issue 52, 2003, Pages 52084-52092

  Jung, Yongwon ^a   Lippard, Stephen J ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; DNA; DRUG PRODUCTS; PLATINUM; RNA; STEREOCHEMISTRY; TUMORS;

LIGANDS;

ENZYMES;

ANTINEOPLASTIC AGENT; CISPLATIN; CYCLOHEXANE DERIVATIVE; DIAMINOCYCLOHEXANE DERIVATIVE; OXALIPLATIN; PLATINUM DERIVATIVE; RNA POLYMERASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA TEMPLATE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME DEGRADATION; EXCISION REPAIR; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; TRANSCRIPTION REGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BASE SEQUENCE; BINDING SITES; CISPLATIN; CPG ISLANDS; CROSS-LINKING REAGENTS; CYANIDES; DNA; DNA REPAIR; DNA-DIRECTED RNA POLYMERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS; IONS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; ORGANOPLATINUM COMPOUNDS; PLATINUM; PROMOTER REGIONS (GENETICS); TRANSCRIPTION, GENETIC; URIDINE TRIPHOSPHATE; VIRAL PROTEINS;

EID: 0347362834     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M310120200     Document Type: Article

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