Dehydroepiandrosterone as an inducer of mitochondrial permeability transition

Journal of Steroid Biochemistry and Molecular Biology

Volumn 87, Issue 4-5, 2003, Pages 279-284

  Correa, Francisco ^a   García, Noemí ^a   García, Gerardo ^a   Chávez, Edmundo ^a  

^a INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

Author keywords

Calcium; Cyclosporin A; Dehydroepiandrosterone; Kidney mitochondria; Permeability transition

Indexed keywords

CALCIUM ANTAGONIST; CALCIUM ION; CYCLOSPORIN A; MEMBRANE LIPID; PRASTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CHANNEL GATING; CONTROLLED STUDY; ELECTRON TRANSPORT; HORMONAL REGULATION; KIDNEY CORTEX; LIPID BILAYER; LIPID PEROXIDATION; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MEMBRANE STRUCTURE; MITOCHONDRIAL MEMBRANE; MITOCHONDRION SWELLING; NONHUMAN; RAT; RESPIRATORY CHAIN;

EID: 0347362547     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2003.09.002     Document Type: Article

References (29)

1. Leowattana W. DHEA(S) the fountain of youth. J. Med. Assoc. Thai. 84(Suppl. 2):2001;S605-S612.
2. Yanase T., Fukahori M., Taniguchi S., Nishi Y., Sakai Y., Takayanagi R., Haji M., Nawata H. Serum dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) in Alzheimer's disease and cerebrovascular dementia. Endocr. J. 43(1):1996;119-123.
3. F.A. Huppert, J.K. Van Niekerk, Dehydroepiandrosterone (DHEA) supplementation for cognitive function, Cochrane Database Syst. Rev. (2001) CD00034.
4. Swierczynski J., Kochan Z., Mayer D. Dietary alpha-tocopherol prevents dehydroepiandrosterone induced lipid peroxidation in rat liver microsomes and mitochondria. Toxicol. Lett. 91(2):1997;129-136.
5. Yang N.C., Jeng K.C., Ho W.M., Hu M.L. ATP depletion is an important factor in DHEA-induced inhibition and apoptosis in BV-2 cells. Life Sci. 70(17):2002;1979-1988.
6. Morales A.J., Haubrich R.H., Hwang J.Y., Asakura H., Yen S.S. The effect of 6 months treatment with 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids. Clin. Endocrinol. 49(4):1998;421-432.
7. Mohan P.F., Cleary M.P. Dehydroepiandrosterone and related steroids inhibit mitochondrial respiration in vitro. Int. J. Biochem. 21(10):1989;1103-1107.
8. Mohan P.F., Cleary M.P. Short-term effects of dehydroepiandrosterone treatment on mitochondrial respiration. J. Nutr. 121(2):1991;240-250.
9. + ATPase of porcine cortex. Eur. J. Pharm. 26(1):1999;95-102.
10. Swierczynski J., Mayer D. Dehydroepiandrosterone-induced lipid peroxidation in rat liver mitochondria. J. Steroid Biochem. Mol. Biol. 58(5-6):1996;599-603.
11. 2+ and includes lipid peroxidation and alteration in membrane proteins. Arch. Biochem. Biophys. 308(1):1994;158-163.
12. Guerrero A., Pamplona R., Portero-Ortín M., Barja G., López-Torres M. Effect of thyroid status on lipid composition and peroxidation in the mouse liver. Free Rad. Biol. Med. 26(1-2):1999;73-80.
13. 2+-induced membrane permeability transition in brain mitochondria. J. Neurochem. 79(6):2001;1237-1245.
14. Crompton M., Costi A., Hayat L. Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria. Biochem. J. 245(3):1987;915-918.
15. Lowry O.H., Rosebrough N., Farr A., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 194(2):1951;265-275.
16. Scarpa A., Brinley F.J., Triffert T., Dubyak G.R. Metallochromic indicators of ionized calcium. Ann. N.Y. Acad. Sci. 307:1978;86-112.
17. Akerman K.E.O., Wikström H. Safranine as a probe of the mitochondrial membrane potential. FEBS Lett. 68(2):1976;191-197.
18. J.A. Buege, S.D. Aust, Microsomal lipid peroxidation, in: S. Fleiser, L. Packer (Eds.), Methods in Enzymology, vol. 52, Academic Press, New York, 1978, pp. 302-310.
19. Berdanier C.M., McIntosh M.K. Further studies on the effects of dehydroepiandrosterone on hepatic metabolism in BHE rats. Proc. Soc. Exp. Biol. Med. 192(3):1989;242-247.
20. Zhang J.G., Tirmenstein M.A., Nicholls-Grzemski F.A., Fariss M.W. Mitochondrial electron transport inhibitors cause lipid peroxidation-dependent and -independent cell death: protective role of antioxidants. Arch. Biochem. Biophys. 393(1):2001;87-96.
21. Fournier N., Ducet G., Crevat A. Action of cyclosporin on mitochondrial calcium fluxes. J. Bioenerg. Biomembr. 19(3):1987;297-303.
22. Broeckemeier K.M., Dempsey M.E., Pfeiffer D.R. Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria. J. Biol. Chem. 264(14):1989;7826-7830.
23. 2+-induced large amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase. Biochem. J. 268(1):1990;153-160.
24. Chávez E., Meléndez E., Zazueta C., Reyes-Vivas H., Perales S. Membrane permeability transition as induced by dysfunction of the electron transport chain. Biochem. Mol. Biol. Int. 41(5):1997;961-968.
25. Bobyleva V., Bellei M., Kneer N., Lardy H. The effect of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship with thermogenesis. Arch. Biochem. Biophys. 341(1):1997;122-128.
26. Bernardi P. Mitochondrial transport of cations: channels, exchangers, and permeability transition. Physiol. Rev. 79(4):1999;1127-1155.
27. Broekemeier K.M., Klocek C.K., Pfeiffer D.R. Proton selective substate of the mitochondrial permeability transition pore: regulation by the redox state of the electron transport chain. Biochemistry. 37(38):1998;13059-13065.
28. Isenberg J.S., Klaunig J.E. Role of the mitochondrial membrane permeability transition (MPT) in rotenone-induced apoptosis in liver cells. Toxicol. Sci. 53(2):2000;340-351.
29. Petronilli V., Penzo D., Scorrano L., Bernardi P., Di Lisa F. The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore opening in situ. J. Biol. Chem. 276(15):2001;12030-12034.