Patterns of Chromosomal Imbalances Defines Subgroups of Breast Cancer with Distinct Clinical Features and Prognosis. A Study of 305 Tumors by Comparative Genomic Hybridization

Cancer Research

Volumn 63, Issue 24, 2003, Pages 8861-8868

  Rennstam, Karin ^a,c   Ahlstedt Soini, Minna ^b   Baldetorp, Bo ^a   Bendahl, Pär Ola ^a   Borg, Åke ^a   Karhu, Ritva ^b   Tanner, Minna ^b   Tirkkonen, Mika ^b   Isola, Jorma ^b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF TAMPERE   (Finland)

^c LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; ESTROGEN RECEPTOR; FLUOROURACIL; METHOTREXATE; PROGESTERONE RECEPTOR; TAMOXIFEN;

ADULT; AGED; ARTICLE; BONFERRONI CORRECTION; BREAST CANCER; BREAST TUMOR; CANCER SURVIVAL; CHROMOSOME 11Q; CHROMOSOME 13Q; CHROMOSOME 16P; CHROMOSOME 16Q; CHROMOSOME 17Q; CHROMOSOME 1Q; CHROMOSOME 20Q; CHROMOSOME 8P; CHROMOSOME 8Q; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME COPY NUMBER ABERRATION; CHROMOSOME GAIN; CHROMOSOME LOSS; COMPARATIVE GENOMIC HYBRIDIZATION; CORRELATION ANALYSIS; FEMALE; FISHER EXACT TEST; GENE DOSAGE; GENE FREQUENCY; GENETIC DISTANCE; GENETICS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE; MAJOR CLINICAL STUDY; MATHEMATICAL ANALYSIS; MULTIVARIATE ANALYSIS; NUCLEIC ACID HYBRIDIZATION; NUMERICAL CHROMOSOME ABERRATION; PATHOLOGY; PHENOTYPE; PHYLOGENETIC TREE CONSTRUCTION METHOD; PLOIDY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; STATISTICAL SIGNIFICANCE; SURVIVAL RATE; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CHROMOSOME ABERRATIONS; FEMALE; GENE DOSAGE; HUMANS; MIDDLE AGED; NUCLEIC ACID HYBRIDIZATION; PHENOTYPE; PROGNOSIS; SURVIVAL RATE;

EID: 0347320782     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Hanahan, D., and Weinberg, R. A. The hallmarks of cancer. Cell, 100: 57-70, 2000.
2. Bieche, I., and Lidereau, R. Genetic alterations in breast cancer. Genes Chromosomes Cancer, 14: 227-251, 1995.
3. Devilee, P., and Cornelisse, C. J. Somatic genetic changes in xhuman breast cancer. Biochim. Biophys. Acta, 1198: 113-130, 1994.
4. van de Vijver, M. J. Molecular genetic changes in human breast cancer. Adv. Cancer Res., 61: 25-56, 1993.
5. Seute, A., Sinn, H. P., Schlenk, R. F., Emig, R., Wallwiener, D., Grischke, E. M., Hohaus, S., Dohner, H., Haas, R., and Bentz, M. Clinical relevance of genomic aberrations in homogeneously treated high-risk stage II/ III breast cancer patients. Int. J. Cancer, 93: 80-84, 2001.
6. Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., and McGuire, W. L. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science (Wash. DC), 235: 177-182, 1987.
7. Gusterson, B. A., Gelber, R. D., Goldhirsch, A., Price, K. N., Save-Soderborgh, J., Anbazhagan, R., Styles, J., Rudenstam, C. M., Golouh, R., Reed, R., et al. Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group. J. Clin. Oncol., 10: 1049-1056, 1992.
8. Thor, A. D., Berry, D. A., Budman, D. R., Muss, H. B., Kute, T., Henderson, I. C., Barcos, M., Cirrincione, C., Edgerton, S., Allred, C., Norton, L., and Liu, E. T. erbB-2, p53, and efficacy of adjuvant therapy in lymph node-positive breast cancer. J. Natl. Cancer Inst. (Bethesda), 90: 1346-1360, 1998.
9. Paik, S., Bryant, J., Park, C., Fisher, B., Tan-Chiu, E., Hyams, D., Fisher, E. R., Lippman, M. E., Wickerham, D. L., and Wolmark, N. erbB-2 and response to doxorubicin in patients with axillary lymph node-positive, hormone receptor-negative breast cancer. J. Natl. Cancer Inst. (Bethesda), 90: 1361-1370, 1998.
10. Silvestrini, R., Benini, E., Veneroni, S., Daidone, M. G., Tomasic, G., Squicciarini, P., and Salvadori, B. p53 and bcl-2 expression correlates with clinical outcome in a series of node-positive breast cancer patients. J. Clin. Oncol., 14: 1604-1610, 1996.
11. Berns, E. M., Klijn, J. G., Smid, M., van Staveren, I. L., Look, M. P., van Putten, W. L., and Foekens, J. A. TP53 and MYC gene alterations independently predict poor prognosis in breast cancer patients. Genes Chromosomes Cancer, 16: 170-179, 1996.
12. Forozan, F., Karhu, R., Kononen, J., Kallioniemi, A., and Kallioniemi, O. P. Genome screening by comparative genomic hybridization. Trends Genet., 13: 405-409, 1997.
13. Kallioniemi, O. P., Kallioniemi, A., Sudar, D., Rutovitz, D., Gray, J. W., Waldman, F., and Pinkel. D. Comparative genomic hybridization: a rapid new method for detecting and mapping DNA amplification in tumors. Semin. Cancer Biol., 4: 41-46, 1993.
14. Jain, A. N., Chin, K., Borresen-Dale, A. L., Erikstein, B. K., Eynstein Lonning, P., Kaaresen, R., and Gray, J. W. Quantitative analysis of chromosomal CGH in human breast tumors associates copy number abnormalities with p53 status and patient survival. Proc. Natl. Acad. Sci. USA, 98: 7952-7957, 2001.
15. Richard, F., Pacyna-Gengelbach, M., Schluns, K., Fleige, B., Winzer, K. J., Szymas, J., Dietel, M., Petersen, I., and Schwendel, A. Patterns of chromosomal imbalances in invasive breast cancer. Int. J. Cancer, 89: 305-310, 2000.
16. Persson, K., Pandis, N., Mertens, F., Borg, A., Baldetorp, B., Killander, D., and Isola, J. Chromosomal aberrations in breast cancer: a comparison between cytogenetics and comparative genomic hybridization. Genes Chromosomes Cancer, 25: 115-122, 1999.
17. Baldetorp, B., Ferno, M., Bendahl, P. O., Fallenius, G., ldvall, I., Akerman, M., and Killander, D. Proliferative index obtained by DNA image cytometry. Does it add prognostic information in Auer IV breast cancer? Am. J. Epidemiol., 20: 144-152, 1998.
18. Malmstrom, P., Bendahl, P. O., Boiesen, P., Brunner, N., Idvall, I., and Ferno, M. S-phase fraction and urokinase plasminogen activator are better markers for distant recurrences than Nottingham Prognostic Index and histologic grade in a prospective study of premenopausal lymph node-negative breast cancer. J. Clin. Oncol., 19: 2010-2019, 2001.
19. Tirkkonen, M., Tanner, M., Karhu, R., Kallioniemi, A., Isola, J., and Kallioniemi, O. P. Molecular cytogenetics of primary breast cancer by CGH. Genes Chromosomes Cancer, 21: 177-184, 1998.
20. Karhu, R., Kahkonen, M., Kuukasjarvi, T., Pennanen, S., Tirkkonen, M., and Kallioniemi, O. Quality control of CGH: impact of metaphase chromosomes and the dynamic range of hybridization. Cytometry, 28: 198-205, 1997.
21. Kallioniemi, O. P., Kallioniemi, A., Piper, J., Isola, J., Waldman, F. M., Gray, J. W., and Pinkel, D. Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors. Genes Chromosomes Cancer, 10: 231-243, 1994.
22. Jiang, F., Desper, R., Papadimitriou, C. H., Schaffer, A. A., Kallioniemi, O. P., Richter, J., Schraml, P., Sauter, G., Mihatsch, M. J., and Moch, H. Construction of evolutionary tree models for renal cell carcinoma from comparative genomic hybridization data. Cancer Res., 60: 6503-6509, 2000.
23. Isola, J. J., Kallioniemi, O. P., Chu, L. W., Fuqua, S. A., Hilsenbeck, S. G., Osborne, C. K., and Waldman, F. M. Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer. Am. J. Pathol., 147: 905-911, 1995.
24. Mars, W. M., and Saunders, G. F. Chromosomal abnormalities in human breast cancer. Cancer Metastasis Rev., 9: 35-43, 1990.
25. Watatani, M., Nagayama, K., Imanishi, Y., Kurooka, K., Wada, T., Inui, H., Hirai, K., Ozaki, M., and Yasutomi, M. Genetic alterations on chromosome 17 in human breast cancer: relationships to clinical features and DNA ploidy. Breast Cancer Res. Treat., 28: 231-239, 1993.
26. Simon, R., Desper, R., Papadimitriou, C. H., Peng, A., Alberts, D. S., Taetle, R., Trent, J. M., and Schaffer, A. A. Chromosome abnormalities in ovarian adenocarcinoma: III. Using breakpoint data to infer and test mathematical models for oncogenesis. Genes Chromosomes Cancer, 28: 106-120, 2000.
27. Brodeur, G. M., Tsiatis, A. A., Williams, D. L., Luthardt, F. W., and Green, A. A. Statistical analysis of cytogenetic abnormalities in human cancer cells. Cancer Genet. Cytogenet., 7: 137-152, 1982.
28. Desper, R., Jiang, F., Kallioniemi, O. P., Moch, H., Papadimitriou, C. H., and Schaffer, A. A. Inferring tree models for oncogenesis from comparative genome hybridization data. J. Comput. Biol., 6: 37-51, 1999.
29. Schoefeld, D. Partial residuals for the proportional hazards regression model. Biometrika. 69: 239-241, 1982.
30. Courjal, F., and Theillet, C. Comparative genomic hybridization analysis of breast tumors with predetermined profiles of DNA amplification. Cancer Res., 57: 4368-4377, 1997.
31. Ried, T., Just, K. E., Holtgreve-Grez, H., du Manoir, S., Speicher, M. R., Schrock. E., Latham, C., Blegen, H., Zetterberg, A., Cremer, T., et al. Comparative genomic hybridization of formalin-fixed, paraffin-embedded breast tumors reveals different pattems of chromosomal gains and losses in fibroadenomas and diploid and aneuploid carcinomas. Cancer Res., 55: 5415-5423, 1995.
32. Nishizaki, T., Chew, K., Chu, L., Isola, J., Kallioniemi, A., Weidner, N., and Waldman, F. M. Genetic alterations in lobular breast cancer by comparative genomic hybridization. Int. J. Cancer, 74: 513-517, 1997.
33. Flagiello, D., Gerbault-Seureau, M., Sastre-Garau, X., Padoy, E., Vielh, P., and Dutrillaux, B. Highly recurrent der(1;16)(q10;p10) and other 16q arm alterations in lobular breast cancer. Genes Chromosomes Cancer, 23: 300-306, 1998.
34. Vos, C. B., ter Haar, N. T., Rosenberg, C., Peterse, J. L., Cleton-Jansen, A. M., Comelisse, C. J., and van de Vijver, M. J. Genetic alterations on chromosome 16 and 17 are important features of ductal carcinoma in situ of the breast and are associated with histologic type. Br. J. Cancer, 81: 1410-1418, 1999.
35. Buerger, H., Mommers, E. C., Littmann, R., Diallo, R., Brinkschmidt, C., Poremba, C., Dockhorn-Dworniczak, B., van Diest, P. J., and Bocker. W. Correlation of morphologic and cytogenetic parameters of genetic instability with chromosomal alterations in in situ carcinomas of the breast. Am. J. Clin. Pathol., 114: 854-859, 2000.
36. Loveday, R. L., Greenman, J., Simcox, D. L., Speirs, V., Drew, P. J., Monson, J. R., and Kerin, M. J. Genetic changes in breast cancer detected by comparative genomic hybridisation. Int. J. Cancer. 86: 494-500, 2000.
37. Nishizaki, T., DeVries, S., Chew, K., Goodson, W. H., III, Ljung, B. M., Thor, A., and Waldman, F. M. Genetic alterations in primary breast cancers and their metastases: direct comparison using modified comparative genomic hybridization. Genes Chromosomes Cancer, 19: 267-272, 1997.
38. Rennstam, K., Baldetorp, B., Kytola, S., Tanner, M., and Isola. J. Chromosomal rearrangements and oncogene amplification precede aneuploidization in the genetic evolution of breast cancer. Cancer Res., 61: 1214-1219, 2001.
39. Kytola, S. R. J., Nordgren, A., Karhu, R., Farnebo, F., Isola, I., and Larsson, C. Chromosomal alterations in 15 breast cancer cell lines by comparative genomic hybridization and spectral karyotyping, Genes Chromosomes Cancer, 28: 308-317, 2000.
40. Tanner, M. M., Tirkkonen, M., Kallioniemi, A., Isola, J., Kuukasjarvi, T., Collins, C., Kowbel, D., Guan, X. Y., Trent, J., Gray, J. W., Meltzer, P., and Kallioniemi, O. P. Independent amplification and frequent coamplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer. Cancer Res., 56: 3441-3445, 1996.