Delineation and decomposition of energies involved in quaternary ammonium binding in the active site of acetylcholinesterase

Journal of the American Chemical Society

Volumn 122, Issue 13, 2000, Pages 2975-2980

  Quinn, Daniel M ^a   Feaster, Shawn R ^a,c   Nair, Haridasan K ^a,d   Baker, Nathan A ^a,b   Radić, Zoran ^b   Taylor, Palmer ^b  

^a E11 SSH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^d HONEYWELL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOPHENONE DERIVATIVE; ACETYLCHOLINESTERASE; ALANINE; PHENYLALANINE; QUATERNARY AMMONIUM DERIVATIVE; TRYPTOPHAN; TYROSINE;

ARTICLE; CATALYSIS; DECOMPOSITION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME STABILITY; ENZYME SUBSTRATE; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS;

EID: 0347314967     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9933588     Document Type: Article

References (40)

1. Abbreviations used: AChE, acetylcholinesterase; Ala, alanine; ATCh, (acetylthio)choline; DTNB, 5,5′-dithiobis(2-nitrobenzoic acid); Glu, glutamic acid; MEPQ, 7-(methylethoxyphosphinyloxy)-N-methyl quinolinium iodide; MR, molar refractivity; Phe, phenylalanine; Ser, serine; TBTFA, m-tert-butyltrifluoroacetophenone; TMTFA, m-(N,N,N-trimethylammonio)trifluoroacetophenone; Trp, tryplophan; Tyr, tyrosine.
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