Modulation of Diabetes with Gonadotropin-Releasing Hormone Antagonists in the Nonobese Mouse Model of Autoimmune Diabetes

Endocrinology

Volumn 145, Issue 1, 2004, Pages 337-342

  Ansari, Mansoor A ^a   Dhar, Minati ^a   Spieker, Sreelatha ^a   Bakht, Noshaba ^a   Rahman, Ayaz M ^a   Moore, Wayne V ^a   Jacobson, Jill D ^a  

^a CHILDREN S MERCY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; GONADORELIN ANTAGONIST; IMMUNOGLOBULIN G; INTERLEUKIN 6; ITURELIX; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DIABETES; AUTOIMMUNE DISEASE; CASTRATION; CELL CULTURE; CONTROLLED STUDY; DIABETES MELLITUS; HORMONAL REGULATION; HORMONE SYNTHESIS; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOMODULATION; INCIDENCE; MALE; MOUSE; MOUSE STRAIN; NEGATIVE FEEDBACK; NONHUMAN; OBESITY; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL;

ANIMALS; AUTOIMMUNITY; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; FEEDBACK, BIOCHEMICAL; GONADOTROPIN-RELEASING HORMONE; HORMONE ANTAGONISTS; IMMUNOGLOBULIN G; INCIDENCE; INTERFERON TYPE II; INTERLEUKIN-6; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED NOD; OLIGOPEPTIDES; ORCHIECTOMY; SPLEEN; TESTOSTERONE;

EID: 0347236891     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0512     Document Type: Article

References (30)

1. Graham J, Hagopian WA, Kockum I, Li LS, Sanjeevi CB, Lowe RM, Schaefer JB, Zarghami M, Day H, Landin-Olsson M, Palmer J, Janer-Villanueva M, Hood L, Sundkvist G, Lemmark A, Breslow N, Dahlquist G, Blohme G 2002 Genetic effects of age-dependent onset and islet cell autoantibody markers in type 1 diabetes. Diabetes 51:1346-1355
2. Roubinian JR, Talal N, Greenspan JS, Goodman JR, Siiteri PK 1978 Effect of castration and sex hormone treatment on survival, anti-nucleic add antibodies, and glomerulonephritis in NZB/NZW Fl mice. J Exp Med 147:1568-1583
3. Hawkins T, Gala RR, Dunbar JC 1993 The effect of neonatal sex hormone manipulation on the incidence of diabetes in nonobese diabetic mice. Proc Soc Exp Biol Med 202:201-205
4. Makino S, Kuninato K, Muraoka Y, Katagiri K 1981 The effect of castration on the appearance of diabetes in NOD mouse. Jikken Dobutsu 30:137-140
5. Fitzpatrick F, Lepault F, Homo-Delarche F, Bach F, Dardenne M 1991 Influence of castration, along or combined with thymectomy, on the development of diabetes in the non-obese diabetic mouse. Endocrinology 129:1382-1390
6. Marchetti B, Guarcello V, Morale MC, Bartoloni G, Raiti F, Palumbo Jr G, Farinella Z, Cordaro S, Scapagnini U 1989 Luteinizing hormone-releasing hormone (LHRH) agonist restoration of age-associated decline of thymus weight thymic LHRH receptors, and thymocyte proliferative capacity. Endocrinology 125:1037-1045
7. Morale MC, Batticane N, Bartoloni G, Guarcello V, Farinella Z, Galasso MG, Marchetti B 1991 Blockade of central and peripheral luteinizing hormone-releasing hormone (LHRH) receptors in neonatal rats with a potent LHRH-antagonist inhibits the morphofunctional development of the thymus and maturation of the cell-mediated and humoral immune responses. Endocrinology 128:1073-1085
8. Batticane N, Morale MC, Gallo F, Farinella Z, Marchetti B 1991 Luteinizing hormone-releasing hormone signaling at the lymphocyte involves stimulation of interleukin-2 receptor expression. Endocrinology 129:277-286
9. Emanuele NV, Emanuele MA, Tender J, Kirsteins L, Azad N, Lawrence AM 1990 Rat spleen lymphocytes contain an immurvoactive and bioactive luteinizing hormone-releasing hormone. Endocrinology 126:2482-2486
10. Maier CC, Marchetti B, Le Boeuf RD, Blalock JE 1992 Thymocytes express a mRNA that is identical to hypothalamic luteinizing hormone-releasing hormone mRNA. Cell Mol Neurobiol 12:447-454
11. Azad N, La Paglia N, Jurgens KA, Kirsteins L, Emanuele NV, Kelley MR, Lawrence AM, Mohagheghpour N 1993 Immunoactivation enhances the concentration of luteinizing hormone-releasing hormone peptide and its gene expression in human peripheral T-lymphocytes. Endocrinology 133:215-223
12. Jacobson JD, Nisula BC, Steinberg AD 1994 Modulation of the expression of murine lupus by gonadotropin-releasing hormone analogs. Endocrinology 134:2516-2523
13. Neill JD, Reichert Jr LE 1971 Development of a radioimmunoassay for rat prolactin and evaluation of the NIAMD rat prolactin radioimmunoassay. Endocrinology 88:548-555
14. Niswender GD, Midgley Jr AR, Monroe SE, Reichert Jr LE 1968 Radioimmunoassay for rat luteinizing hormone with antiovine LH serum and ovine LH-131-I. Proc Soc Exp Biol Med 128:807-811
15. Mantel N 1966 Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50:163-170
16. Ansar Ahmed S, Penhale WJ, Talal N 1985 Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action. Am J Pathol 121:531-551
17. Deleted in proof
18. Finkelstein JS, Whitcomb RW, O'Dea L, Longcope C, Schoenfeld DA, Crowley Jr WF 1991 Sex steroid control of gonadotropin secretion in the human male. I. Effects of testosterone administration in normal and gonadotropin-releasing hormone-deficient men. J Clin Endocrinol Metab 73:609-620
19. Veldhuis JD, Urban RJ, Dufau ML 1992 Evidence that androgen negative feedback regulates hypothalamic gonadotropin-releasing hormone impulse strength and the burst-like secretion of biologically active luteinizing hormone in men. J Clin Endocrinol Metab 74:1227-1235
20. Kalra PS, Kalra SP1982 Discriminative effects of testosterone on hypothalamic luteinizing hormone-releasing hormone levels and luteinizing hormone secretion in castrated male rats: analyses of dose and duration characteristics. Endocrinology 111:24-29
21. Russell DH, Kibler R, Matrisian L, Larson DF, Poulos B, Magun BE 1985 Prolactin receptors on human T and B lymphocytes: antagonism of prolactin binding by cydosporine. J Immunol 134:3027-3031
22. Walker SE, McMurray RW, Houri JM, Allen SH, Keisler D, Sharp GC, Schlechte JA 1998 Effects of prolactin in stimulating disease activity in systemic lupus erythematosus. Ann NY Acad Sci 840:762-772
23. Jacobson JD, Crof ford LJ, Sun L, Wilder RL1998 Cyclical expression of GnRH and GnRM receptor mRNA in lymphoid organs. Neuroendocrinology 67: 117-125
24. Jacobson JD, Ansari MA, Kinealy M, Muthukrishnan V 1999 Gender specific exacerbation of murine lupus by gonadotropin-releasing hormone: potential role of Gαq/11. Endocrinology 140:3429-3437
25. Anderson JT, Cornelius JG, Jarpe, Winter WE, Peck AB 1993 Insulin-dependent diabetes in the NOD mouse model. II β Cell destruction in autoimmune diabetes is a TH2 and not a TH1 mediated event. Autoimmunity 15:113-122
26. Kitani H, Hara M, Hirose T, Harigai M, Suzuki K, Kawakami M, Kawaguchi Y, Hidaka T, Kawagoe M, Nakamura H 1992 Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus. Clin Exp Immunol 88:75-83
27. Yang G, Liu H, Jiang M, Jiang X, Li S, Yuan Y, Ma D 1998 Experimental study on intramuscular injection of eukaryotic expression vector pcDNA3-IL-6 on BXSB mice. Chin Med J 111:38-42
28. Cross J, Benton H 1999 The roles of interleukin-6 and interleukin-10 in B cell hyperactivity in systemic lupus erythematosus. Inflamm Res 48:255-261
29. Serreze DV, Chapman HD, Vamum DS, Hanson MS, Reifsnyder PC, Richard SD, Fleming SA, Leiter EH, Shultz LD 1996 B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig i null mice. J Exp Med 184:2049-2053
30. Silviera PA, Johnson E, Chapman HD, Bui T, Tisch RM, Serreze DV 2002 The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self-antigen-specific immunoglobulin receptors. Eur J Immunol 32:3657-3666