Enzymatic synthesis of multi-component copolymers and their structural characterization

Molecular Diversity

Volumn 6, Issue 3-4, 2003, Pages 287-295

  Kumar, Rajesh ^a,b   Tyagi, Rahul ^b,c   Parmar, Virinder S ^a,c   Samuelson, Lynne A ^d   Kumar, Jayant ^b   Watterson, Arthur C ^a  

^a University of Massachusetts Lowell   (United States)

^b UNIVERSITY OF MASSACHUSETTS LOWELL   (United States)

^c UNIVERSITY OF DELHI   (India)

^d DEVELOPMENT AND ENGINEERING CENTER   (United States)

Author keywords

1, alkanediols; 1,6 hexanediamine and 1,6 hexanedithiol; 1,6 hexanediol; Candida antarctica lipase B; Dimethyl 5 hydroxyisophthalate; Enzymes; Multi component copolymers; Poly (ethylene glycol); Terpolymerization; Transesterification

Indexed keywords

1,10 DECANEDIOL; 1,12 DODOCANEDIOL; 1,14 TETRADECANEDIOL; 1,16 HEXADECANEDIOL; 1,4 BUTANEDIOL; 1,6 HEXANEDIAMINE; 1,6 HEXANEDIOL; 1,6 HEXANEDITHIOL; 1,8 OCTANEDIOL; ALKANEDIOL DERIVATIVE; AMINE; COPOLYMER; DIMETHYL 5 HYDROXYISOPHTHALATE; HYDROXYL GROUP; LIPASE B; MACROGOL; MACROGOL 600; MACROGOL DERIVATIVE; POLYAMIDE; POLYESTER; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

CANDIDA ANTARCTICA; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYST; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONFERENCE PAPER; GEL PERMEATION CHROMATOGRAPHY; INFRARED SPECTROSCOPY; MULTICOMPONENT REACTION; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; SYNTHESIS;

CANDIDA; LIPASE; POLYESTERS; POLYETHYLENE GLYCOLS; POLYMERS; SOLVENTS;

EID: 0347132222     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:MODI.0000006820.04426.97     Document Type: Conference Paper

References (24)

1. Frazza, E. J. and Schmitt, E. E., New absorbable suture, J. Biomed. Mater. Res., 1 (1970) 43-49.
2. Kobayashi, S., Hyon, H. and Ikada, Y., Progress in medical imaging and surgery of liver cancer, J. Biomed. Mater. Res., 25 (1991), 1481-1489.
3. Daniels, A. U., Chang, M. K. D. and Andriano, K. P., Mechanical properties of biodegradable polymers and composites proposed for internal fixation of bone, J. Appl. Biomater., 1 (1990), 57-64.
4. Chasin, M. and Langer, R., (eds.), Biodegradable Polymers as Drug Delivery Systems, Marcel Dekker, New York (1990).
5. Kumar, R. and Gross, R. A., Biocatalytic route to well-defined macromers built around a sugar core, J. Am. Chem. Soc., 124 (2002) 1850-1851.
6. Sharma, S. K., Roy, S., Kumar, R. and Parmar, V. S., Novel diastereoselective acylation of 4-C-hydroxymethyl-1,2-O-(1-methylethylidene)-3-O-(phenylmethyl)-D-pentofuranose: effect of lipases and acylating agents on stereoselectivity, Tetrahedron Lett., 40 (1999) 9145-9146.
7. Parmar, V. S., Prasad, A. K., Pati, H. N., Kumar, R., Azim, A., Roy, S. and Errington, W., Enzyme-catalyzed chemoselective transesterification reactions on hydroxymethylated phenolic compounds, Bioorg. Chem., 27 (1999) 119-134.
8. Kumar, R., Azim, A., Kumar, V., Sharma, S. K., Prasad, A. K., Howarth, O. W., Olsen, C. E., Jain, S. C. and Parmar, V. S., Lipase-catlyzed chemo- and enantioselective acetylation of 2-alkyl/aryl-3-hydroxypropiophenones, Bioorg. Med. Chem., 9 (2001) 2643-2652.
9. Gross, R. A., Kumar, A. and Kalra, B., Polymer synthesis by in vitro enzyme catalysis, Chem. Rev., 101 (2001) 2097-2124.
10. Kobayashi, S., Uyama, H. and Kimura, S., Enzymatic polymerizations, Chem. Rev., 101 (2001) 3793-3818.
11. Binns, F., Roberts, S. M., Taylor, A. and Williams, C. F., Enzymic polymerization of unactivated diol/diacid system, J. Chem. Soc., Perkin Trans. 1 (1993) 899-900.
12. Wallace, J. S. and Morrow, C. J., Biocatalytic synthesis of polymers. II. Preparation of [AA-BB]x polyesters by porcine pancreatic lipase catalyzed transesterification in anhydrous, low polarity organic solvents, J. Polym. Sci. Part A: Poly. Chem., 27 (1989) 3271-3278.
13. Linko, Y. Y., Wang, Z. L. and Seppala, J., Lipase biocatalysis in the production of esters, J Biotechnol., 40 (1995) 133-135.
14. Uyama, H., Inafda, K. and Kobayashi, S., In vitro enzymatic synthesis and applications of poly(amino acid)s, Kagaku Kogaku Ronbun, 54 (2003) 112-117.
15. Binns, F., Harffey, P., Roberts, S. M. and Taylor, A., Studies of lipase-catalyzed polyesterification of an unactivated diol/diacid system, J. Polym. Sci. Part A: Polym. Chem., 36 (1998) 2069-2078.
16. 1H-NMR relaxation times (T1), Polymer Preprints, 42 (2001) 189-200.
17. Kumar, R., Shakil, N. A., Chen, M.-H., Parmar, V. S. and Watterson, A. C., Chemo-enzymatic synthesis of novel functionalized amphiphilic polymer, Polymer Preprints, 43 (2002) 578-579.
18. Kumar, R., Shakil, N. A., Chen, M.-H., Parmar, V. S., Samuelson, L. A., Kumar, J., Watterson, A. C., Chemo-enzymatic synthesis and characterization of novel functionalized amphiphilic polymers, J. Macromol. Sci. - Pure. Appl. Chem., 39 (2002) 1137-1149.
19. Kumar, R., Shakil, N. A., Chen, M.-H., Parmar, V. S., Samuelson, L. A., Kumar, J. and Watterson, A. C., Synthetic and mechanistic studies on biocatalytic reactions generating novel amphiphilic polymers, Polymer Preprints, 43 (2002) 879-880.
20. Kumar, R., Shakil, N. A., Chen, M.-H., Parmar, V. S., Samuelson, L. A., Kumar, J. and Watterson, A. C., Novel self-assembled polymeric nano-particles for drug delivery: Chemoenzymatic synthesis, characterization and applications, J. Am. Chem. Soc., communicated.
21. Chen, M.-H., Kumar, R., Yang, K., Parmar, V. S., Samuelson, L. A., Kumar, J. and Watterson, A. C., Studies on the supramolecular organization of amphiphilic copolymers into nano-micelles by light scattering techniques, Polymer Preprints, 44 (2003) 1199-1200.
22. Karayannidis, G. P., Sideridou, I. D., Zamboulis, D. N. and Bikiaris, A. J., Thermal behavior and tensile properties of poly(ethylene terephthalate-co-ethylene isophthalate), J. Appl. Polym. Sci., 78 (2000) 200-208.
23. Mahapatro, A., Kalra, B., Kumar, A. and Gross, R. A., Lipase-catalyzed polycondensations: effect of substrates and solvent on chain formation, dispersity, and end-group structure, Biomacromolecules, 4 (2003) 544-551.
24. Ohmer, N., Orrenius, C., Mattson, A., Norin, T. and Hult, K., Kinetic resolutions of amine and thiol analogues of secondary alcohols catalyzed by the Candida antarctica lipase B, Enzyme Microb. Technol., 19 (1996) 328-331.