Magnetic resonance imaging of cerebral microbleeds

Current Opinion in Neurology

Volumn 13, Issue 1, 2000, Pages 69-73

  Roob, Gudrun ^a   Fazekas, Franz ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; HEMOSIDERIN; SALICYLIC ACID;

BRAIN HEMORRHAGE; HISTOPATHOLOGY; HUMAN; HYALINE DEGENERATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTION; SHORT SURVEY; VASCULAR AMYLOIDOSIS; ADULT; AGED; BLOOD VESSEL INJURY; BLOOD VESSEL WALL; BRAIN ISCHEMIA; CLINICAL TRIAL; ELECTRON SPIN RESONANCE; HYPERTENSION; LIPOFIBROHYALINOSIS; MICROANEURYSM; MICROANGIOPATHY; MICROVASCULATURE; RECURRENT DISEASE; RISK FACTOR; STROKE; VASCULAR DISEASE;

CEREBRAL HEMORRHAGE; HUMANS; MAGNETIC RESONANCE IMAGING;

EID: 0034006604     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019052-200002000-00013     Document Type: Short Survey

References (17)

1. Brott T, Thalinger K, Hertzberg V. Hypertension as a risk factor for spontaneous intracerebral hemorrhage. Stroke 1986; 17:1078-1083.
2. Inzitari D, Giordano G, Ancona A, Pracucci G, Mascalchi M, Amaducci L. Leukoaraiosis, intracerebral hemorrhage, and arterial hypertension. Stroke 1990; 21:1419-1423.
3. The Stroke Prevention in Reversible Ischemia Trial (SPIRIT) Study Group. A randomised trial of anticoagulants versus aspirin after cerebral ischemia of presumed arterial origin. Ann Neurol 1997; 42:857-865.
4. Fazekas F, Kleinert R, Roob G, Kleinert G, Kapeller P, Schmidt R, et al. Histopathologic analysis of foci of signal loss in gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol 1999; 20:637-642. • This correlative MRI-histopathologic study on 11 brain specimens provided confirmation of microangiopathy-related perivascular hemosiderin deposits as prevailing morphologic substrates for focal areas of signal loss in brains with ICH.
5. Greenberg S, Finkelstein S, Schaefer P. Petechial hemorrhages accompanying lobar hemorrhage: detection by gradient echo MRI. Neurology 1996; 46:1751-1754.
6. Scharf J, Brauherr E, Forsting M, Sartor K. Significance of haemorrhagic lacunes on MRI in patients with hyperintense cerebrovascular diseases and intracerebral haemorrhage. Neuroradiology 1994; 37:504-508.
7. Offenbacher H, Fazekas F, Schmidt R, Koch M, Fazekas G, Kapeller P. MR of cerebral abnormalities concomitant with primary intracerebral hematomas. AJNR Am J Neuroradiol 1996; 17:573-578.
8. Kwa V, Franke C, Verbeeten B, Stam J. Silent intracerebral microhemorrhages in patients with ischemic stroke. Ann Neurol 1998; 44:372-377. •• This is the first study to search for MRI evidence of old intracerebral bleeds in patients with different types of ischaemic vacular disease. Hemosiderin deposits were significantly more frequent in individuals with ischaemic stroke than in those with peripheral arterial disease or myocardial infarction, which was suggested to explain their higher incidence of ICHs if treated with oral anticoagulants.
9. Tanaka A, Ueno Y, Nakayama Y, Takano K, Takebayashi S. Small chronic hemorrhages and ischemic lesions in association with spontaneous intracerebral hematomas. Stroke 1999; 30:1637-1642. • This is a confirmatory study on the prevalence of microbleeds in patients with ICH, hypertension and ischaemic microangiopathy, including detailed histopathologic work-up of three brain specimens.
10. Roob G, Schmidt R, Kapeller P, Lechner A, Hartung H, Fazekas F. MRI evidence of past cerebral microbleeds in a healthy elderly population: the Austrian Stroke Prevention Study. Neurology 1999; 52:991-994. •• This study prospectively examined the prevalence of microbleeds in 280 elderly community dwelling volunteers without neurologic symptoms. Extensive and longitudinal evaluation of participating individuals allowed for a detailed analysis of morphologic findings and cerebrovascular risk factors associated with the MRI evidence of focal hemosiderin deposits.
11. Greenberg S, O'Donnell H, Schaefer P, Kraft E. MRI detection of new hemorrhages: potential marker of progression in cerebral amyloid angiopathy. Neurology 1999; 22:1135-1138. •• An intriguing observation of new hemosiderin deposits is presented in 12 out of 24 patients with probable and possible CAA after 1.5 years of follow up.
12. Weller R. Spontaneous intracranial hemorrhage. In: Greenfield's neuropathology, 5th ed. Adams J, Duchen L (editors). London: Edward Arnold; 1992. pp. 269-301.
13. Hino A, Fujimoto M, Yamaki T, Iwamoto Y, Katsumori T. Value of repeat angiography in patients with spontaneous subcortical hemorrhage. Stroke 1998; 29:2517-2521. • Considerations regarding repeat angiography in order to avoid missing vascular malformations, that are based on diagnostic work-up of 137 consecutive patients with subcortical haemorrhage, are presented.
14. Greenberg S. Cerebral amyloid angiopathy: prospects for clinical diagnosis and treatment. Neurology 1998; 51:690-694. • A review of the diagnosis of CAA during life and possible approaches to prevention is presented.
15. Natte R, Vinters H, Maatschieman M, Bornebroek M, Haan J, Roos R, et al. Microvasculopathy is associated with the number of cerebrovascular lesions in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Stroke 1998; 29:1588-1594.
16. Bae H, Jeong D, Doh J, Lee K, Yun I, Byun B. Recurrence of bleeding in patients with hypertensive intracerebral hemorrhage. Cerebrovasc Dis 1999; 9:102-108.
17. Gonzales-Duarte A, Cantu C, Ruizsandoval J, Barinagarrementeria F. Recurrent primary cerebral hemorrhage: frequency, mechanisms, and prognosis. Stroke 1998; 29:1802-1805.