PGH2-TxA2-receptor blockade restores vasoreactivity in a new rodent model of genetic hypertension

Journal of Applied Physiology

Volumn 88, Issue 6, 2000, Pages 1983-1988

  Suzuki, Hideyuki ^a   Ikezaki, Hiroyuki ^a   Hong, Dennis ^a   Rubinstein, Israel ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Acetylcholine; Essential hypertension; Microcirculation; Nitric oxide; Nitroglycerin; Prostaglandins; SQ 29548; Vasoactive intestinal peptide; Vasomotor tone

Indexed keywords

7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; ACETYLCHOLINE; GLYCERYL TRINITRATE; PROSTAGLANDIN H2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; THROMBOXANE A2; THROMBOXANE RECEPTOR BLOCKING AGENT; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CHEEK MUCOSA; DRUG MECHANISM; DRUG RECEPTOR BINDING; ESSENTIAL HYPERTENSION; HAMSTER; MALE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; VASOMOTOR REFLEX;

EID: 0033920116     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.6.1983     Document Type: Article

References (45)

1. 2 receptor antagonists inhibit endothelium-dependent contractions. Hypertension 15: 699-703, 1990.
2. Brush JED Jr, Faxon DP, Salmon S, Jacobs AK, and Ryan TJ. Abnormal endothelium-dependent coronary vasomotion in hypertensive patients. J Am Coll Cardiol 19: 809-815, 1992.
3. Cardillo C and Panza JA. Impaired endothelial regulation of vascular tone in patients with systemic arterial hypertension. Vasc Med 3: 138-144, 1998.
4. + channels in mediating heterogeneous microvascular responses to acetylcholine in different vascular beds. J Pharmacol Exp Ther 282: 1474-1479, 1997.
5. Diederich D, Yang Z, Bühler FR, and Lüscher TF. Impaired endothelium-dependent relaxations in hypertensive resistance arteries involve cyclooxygenase pathway. Am J Physiol Heart Circ Physiol 258: H445-H451, 1990.
6. Durán WN and Dillon PK. Acute microcirculatory effects of platelet-activating factor. J Lipid Mediat 2, Suppl: S215-S227, 1990.
7. 2 are contractile factors in intrarenal arteries of spontaneously hypertensive rats. Hypertension 19: 795-798, 1992.
8. Gulati A, Artwohl JE, Kumar A, Gao X-P, and Rubinstein I. Endothelin-1-like immunoreactivity in a new rodent model of spontaneous hypertension. Am J Hypertens 11: 866-869, 1998.
9. Gulbenkian S, Opgaard OS, Ekman R, Andrade NC, Wharton J, Polak JM, Queiroz e Melo J, and Edvinsson L. Peptidergic innervation of human epicardial coronary arteries. Circ Res 73: 579-588, 1993.
10. 2 analog. Arch Int Pharmacodyn Ther 259: 180-185, 1982.
11. Herrmann KS and Kreuzer H. Effect of serotonergic antagonism on local responses to an acute and selective endothelial trauma in vivo. J Cardiovasc Pharmacol 16, Suppl 3: S40-S44, 1990.
12. Kaji A, Shigematsu H, Fujita K, Maeda T, and Watanabe S. Parasympathetic innervation of cutaneous blood vessels by vasoactive intestinal polypeptide-immunoreactive and acetylcholinesterase-positive nerves: histochemical and experimental study on rat lower lip. Neuroscience 25: 353-362, 1988.
13. 2 may be the endothelium-derived contracting factor released by acetylcholine in the aorta of the rat. Hypertension 15: 475-481, 1990.
14. Kawamura K and Takebayashi S. The development of noradrenaline-, acetylcholinesterase-, neuropeptide Y- and vasoactive intestinal polypeptide-containing nerves in human cerebral arteries. Neurosci Lett 175: 1-4, 1994.
15. Kummer W, Fischer A, Mundel P, Mayer B, Hoba B, Philippin B, and Preissler U. Nitric oxide synthase in VIP-containing vasodilator nerve fibers in the guinea-pig. Neuroreport 3: 653-655, 1992.
16. Lin L and Nasjletti A. Role of endothelium-derived prostanoid in angiotensin-induced vasoconstriction. Hypertension 18: 158-164, 1991.
17. Lüscher TF. Imbalance of endothelium-derived relaxing and contracting factors. A new concept in hypertension? Am J Hypertens 3: 317-330, 1990.
18. Matrougui K, Maclouf J, Lévy BI, and Henrion D. Impaired nitric oxide- and prostaglandin-mediated responses to flow in resistance arteries of hypertensive rats. Hypertension 30: 942-947, 1997.
19. 2 in responses of cerebral arterioles during chronic hypertension. Am J Physiol Heart Circ Physiol 262: H539-H543, 1992.
20. Mayhan WG and Rubinstein I. Acetylcholine induces vasoconstriction in the microcirculation of cardiomyopathic hamsters: reversal by L-arginine. Biochem Biophys Res Commun 184: 1372-1377, 1992.
21. Mayhan WG and Rubinstein I. Response of hamster cheek pouch microcirculation to endothelin and endothelin receptor antagonists. Int J Microcirc Clin Exp 15: 48-52, 1995.
22. Minkes RK, Lippton HL, Armstead WM, Lepak KA, Higuera TR, McNamara DB, and Kadowitz PJ. Influence of SQ 29,548 on vasoconstrictor responses in the mesenteric vascular bed of the cat. Eur J Pharmacol 179: 119-127, 1990.
23. Ogletree ML, Harris DN, Greenberg R, Haslanger MF, and Nakane M. Pharmacological actions of SQ 29,549, a novel selective thromboxane antagonist. J Pharmacol Exp Ther 234: 435-441, 1985.
24. Önyüksel H, Ikezaki H, Patel M, and Rubinstein I. A novel formulation of VIP in sterically stabilized micelles amplifies vasodilation in vivo. Pharm Res 16: 155-160, 1999.
25. Panza JA, Casino PR, Kilocoyne CM, and Quyyumi AA. Impaired endothelium-dependent vasodilation in patients with essential hypertension: evidence that the abnormality is not at the muscarinic receptor level. J Am Coll Cardiol 23: 1610-1616, 1994.
26. Pinho MS, Sebastiao AM, Rodrigues G, Barroso CP, Ribeiro JA, Mata LR, and Gulbenkian S. Vasoactive intestinal peptide in the hamster seminal vesicle: distribution, binding sites and possible functions. Neuroscience 59: 1083-1091, 1994.
27. Preston RA, Materson BJ, Reda DJ, Williams DW, Hamburger RJ, Cushman WC, and Anderson RJ. Age-race subgroup compared with renin profile as predictors of blood pressure response to antihypertensive therapy. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. JAMA 280: 1168-1172, 1998.
28. Ramírez MM, Quardt SM, Kim D, Oshiro H, Minnicozzi M, and Durán WN. Platelet activating factor modulates microvascular permeability through nitric oxide synthesis. Microvasc Res 50: 223-234, 1995.
29. Rapoport RM and Williams SP. Role of prostaglandins in acetylcholine-induced contraction of aorta from spontaneously hypertensive and Wistar-Kyoto rats. Hypertension 28: 64-75, 1996.
30. Rubinstein I, Houmsse M, Davis RG, and Vishwanatha JK. Tissue angiotensin I-converting enzyme activity in spontaneously hypertensive hamsters. Biochem Biophys Res Commun 183: 1117-1123, 1992.
31. Rubinstein I and Mayhan WG. L-Arginine dilates cheek pouch arterioles in hamsters with hereditary cardiomyopathy but not in controls. J Lab Clin Med 125: 313-318, 1995.
32. Rubinstein I, Yong T, Rennard SI, and Mayhan WG. Cigarette smoke extract attenuates endothelium-dependent arteriolar dilatation in vivo. Am J Physiol Heart Circ Physiol 261: H1913-H1918, 1991.
33. Saetrum Opgaard O, Gulbenkian S, Bergdahl A, Barroso CP, Costa Andrade N, Polak JM, Queiroz e Melo J, and Edvinsson L. Innervation of human epicardial coronary veins: immunohistochemistry and vasomotility. Cardiovasc Res 29: 463-468, 1995.
34. Saitongdee P, Milner P, Loesch A, Knight G, and Burnstock G. Electron-immunohistochemical studies of perivascular nerves of mesenteric and renal arteries of golden hamsters during and after arousal from hibernation. J Anat 195: 121-130, 1999.
35. Séjourné F, Rubinstein I, Suzuki H, and Alkan-Önyüksel H. Development of a novel bioactive formulation of vasoactive intestinal peptide in sterically stabilized liposomes. Pharm Res 14: 362-365, 1997.
36. Shepherd RK and Duling BR. Inosine-induced vasoconstriction is mediated by histamine and thromboxane derived from mast cells. Am J Physiol Heart Circ Physiol 270: H560-H566, 1996.
37. Suzuki H, Gao X-P, Olopade CO, Jaffe AH, Pakhlevaniants S, and Rubinstein I. Aqueous smokeless tobacco extract impairs endothelium-dependent vasodilation in the oral mucosa. J Appl Physiol 81: 225-231, 1996.
38. Suzuki H, Gao X-P, Olopade CO, and Rubinstein I. Neutral endopeptidase modulates vasoactive intestinal peptide-induced vasodilation in situ. Am J Physiol Regulatory Integrative Comp Physiol 271: R393-R397, 1996.
39. Suzuki H, Noda Y, Gao X-P, Séjourné F, Alkan-Önyüksel H, Paul S, and Rubinstein I. Encapsulation of VIP into liposomes restores vasorelaxation in hypertension in situ. Am J Physiol Heart Circ Physiol 271: H282-H287, 1996.
40. Tang T and Joyner WL. Differential role of endothelial function on vasodilator responses in series-arranged arterioles. Microvase Res 44: 61-72, 1992.
41. The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Arch Intern Med 157: 2413-2446, 1997.
42. Thomas CL, Artwohl JE, Suzuki H, Gao X-P, White E, Saroli A, Bunte RM, and Rubinstein I. Initial characterization of hamsters with spontaneous hypertension. Hypertension 30: 301-304, 1997.
43. Vanhoutte PM. Endothelial dysfunction in hypertension. J Hypertens Suppl 14: S83-S93, 1996.
44. Verbeuren TJ, Valiez MO, Lavielle G, and Bouskela E. Activation of thromboxane receptors and the induction of vasomotion in the hamster cheek pouch microcirculation. Br J Pharmacol 122: 859-866, 1997.
45. Vishwanatha JK, Davis RG, Blumberg S, Gao X-P, and Rubinstein I. Increased tissue neutral endopeptidase 24.11 activity in spontaneously hypertensive hamsters. Am J Hypertens 11: 585-590, 1998.