Cutting Edge: Stimulation with the Cognate Self-Antigen Induces Expression of the Ly49A Receptor on Self-Reactive T Cells Which Modulates Their Responsiveness

Journal of Immunology

Volumn 171, Issue 12, 2003, Pages 6334-6338

  Saurer, Leslie ^a,c   Seibold, Inge ^a   Vallan, Claudio ^a   Held, Werner ^b   Mueller, Christoph ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; AUTOANTIGEN; BLOCKING ANTIBODY; CD8 ANTIGEN; COGNATE SELF ANTIGEN; GLYCOPROTEIN; GLYCOPROTEIN PEPTIDE 33 41, LYMPHOCYTIC CHORIOMENINGITIS VIRUS; GLYCOPROTEIN PEPTIDE 33-41, LYMPHOCYTIC CHORIOMENINGITIS VIRUS; H2 ANTIGEN; HISTOCOMPATIBILITY ANTIGEN H 2D(B); HISTOCOMPATIBILITY ANTIGEN H-2D(B); LY 49 ANTIGEN; LY ANTIGEN; LY-49 ANTIGEN; LY49A RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NK1.1 ANTIGEN; PEPTIDE; PEPTIDE FRAGMENT; PROTEIN; PROTEIN GP33; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG; VIRUS ANTIGEN; VIRUS PROTEIN;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; IMMUNOPHENOTYPING; IMMUNOREACTIVITY; IMMUNOSTIMULATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; METABOLISM; MOUSE; MOUSE MUTANT; MOUSE STRAIN; NATURAL KILLER CELL; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

EID: 0346996877     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.12.6334     Document Type: Article

References (20)

1. Takei, F. J. Brennan, and D. L. Maget. 1997. The Ly-49 family: genes, proteins and recognition of class I MHC. Immunol. Rev. 155:67.
2. Long, E. O. 1999. Regulation of immune responses through inhibitory receptors. Annu. Rev. Immunol. 17:875.
3. Ljunggren, H. G., and K. Karre. 1990. In search of the 'missing self: MHC molecules and NK cell recognition. Immunol. Today 11:237.
4. Coles, M. C., C. W. McMahon, H. Takizawa, and D. H. Rauler. 2000. Memory CD8 T lymphocytes express inhibitory MHC-specific Ly49 receptors. Eur. J. Immunol. 30:236.
5. + T cells expressing NK cell receptots in influenza A virus-infected mice. J. Immunol. 165:4964.
6. + T cells. J. Immunol. 164:2009.
7. + T cells. J. Immunol. 169:1444.
8. Arase, H., T. Saito, J. H. Phillips, and L. L. Lanier. 2001. Cutting edge: Be the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (α2 integrin, very late antigen-2). J. Immunol. 167:1141.
9. + cells. J. Immunol. 160:1158.
10. Zajac, A. J., R. E. Vance, W. Held, D. J. Sourdive, J. D. Altman, D. H. Raulet, and R. Ahmed. 1999. Impaired anti-viral T cell responses due to expression of the Ly49A inhibitory receptor. J. Immunol. 163:5526.
11. Brawand, P., F. A. Lemonnier, H. R. MacDonald, J. C. Cerottini, and W. Held. 2000. Transgenic expression of Ly49A on T cells impairs a specific antitumor response. J. Immunol. 165:1871.
12. Roger, J., A. Chalifour, S. Lemieux, and P. Duplay. 2001. Cutting edge: Ly49A inhibits TCR/CD3-induced apoptosis and IL-2 secretion. J. Immunol. 167:6
13. Chambers, C. A., J. Kang, Y. Wu, W. Held, D. H. Raulet, and J. P. Allison. 2002. The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor. Blood 99:4509.
14. Pircher, H., T. W. Mak, R. Lang, W. Ballhausen, E. Ruedi, H. Hengartner, R. M. Zinkernagel, and K. Burki. 1989. T cell tolerance to Misa encoded antigens in T cell receptor V/β8.1 chain transgenic mice. EMBO J. 8:719.
15. + T cells to cause immunopathology. J. Exp. Med. 187:763.
16. Roland, J., and P. A. Cazenave. 1992. Ly-49 antigen defines αβ TCR population in i-IEL with an extrathymic maturation. Int. Immunol. 4:699.
17. Bendelac, A., M. N. Rivera, S. H. Park, and J. H. Roark. 1997. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 15:535.
18. Held, W., B. Kunz, B. Lowin-Kropf, M. van de Wetering, and H. Clevers. 1999. Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1. Immunity 11:433.
19. + T cells specific for melanocyte differentiation antigens expresses killer inhibitory receptors (KIR) in healthy donors: evidence for a role of KIR in the control of peripheral tolerance. Eur. J. Immunol. 30:1665.
20. + T cells is controlled by T-cell receptor engagement. Nature 403:325.