Contents of Anti-Tumor Polysaccharides in Certain Mushrooms and Their Immunomodulating Activities

Food Science and Technology Research

Volumn 7, Issue 1, 2001, Pages 31-34

  Mizuno, Masashi ^a   Minato, Ken Ichiro ^a   Kawakami, Sachiko ^a   Tatsuoka, Shigenobu ^a   Denpo, Yutaka ^a   Tsuchida, Hironobu ^a  

^a KOBE UNIVERSITY   (Japan)

Author keywords

Anti tumor polysaccharides; Immunomodulating activity; Mushrooms; Nitric oxide (NO); Splenic lymphocyte subsets; Tumor necrosis factor (TNF)

Indexed keywords

BASIDIOMYCOTA; GRIFOLA FRONDOSA; LENTINULA EDODES; LENTINUS; MERIPILUS;

EID: 0346977911     PISSN: 13446606     EISSN: None     Source Type: Journal    
DOI: 10.3136/fstr.7.31     Document Type: Article

References (28)

1. Chihara, G., Maeda, Y., Hamuro, J., Sasaki, T. and Fukuoka, F. (1969). Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes (Berk.) Sing. Nature, 222, 687-688.
2. Chihara, G., Hamuro, J., Maeda, Y., Arai, Y. and Fukuoka, F. (1970). Fractionation and purification of the polysaccharides with marked anti-tumor activity, especially lentinan, from Lentinus edodes (Berk.) Sing. (an edible mushroom). Cancer Res., 30, 2776-2781.
3. Freunhauf, J. P., Bonnard, G. D. and Heberman, R. B. (1982). The effect of lentinan on production of interleukin-1 by human monocytes. Immunopharmacology, 5, 65-74.
4. Gergely, P., Vallent, K., Bodo, I., Feher, J. and Kaneko, Y. (1988). Effects of lentinan on cytotoxic functions of human lymphocytes. Immunopharmacol. Immunotoxicol., 10, 157-163.
5. Hamuro, J., Röllinghoff, M. and Wagner, H. (1980). Induction of cytotoxic peritoneal exudate cells by T cell immune adjuvants of β-(1-3) glucan type Lentinan and its analogous. Immunology, 39, 551-559.
6. Ikekawa, T., Ideda, Y., Yoshioka, Y., Nakanishi, K., Yokoyama, E. and Yamazaki, E. (1982). Studies on anti-tumor polysaccharides of Flammulina velutipes (Curt. ex. Fr.) Sing II. The structure of EA 3 and further purification of EA 5. J. Pharmacobiodyn., 5, 576-581.
7. Ito, H., Shimura, K., Itoh, H. and Kawade, M. (1997). Antitumor effects of a new polysaccharide-protein complex (ATOM) prepared from Agaricus blazei (Iwade strain 101) "Himematsutake" and its mechanism in tumor-bearing mice. Anticancer Res., 17, 277-284.
8. Kawagishi, H., Inagaki, R., Kanao, T., Mizuno, T., Shimura, K., Ito, H., Hagiwara, T. and Nakamura, T. (1989). Fractionation and anti-tumor activity of the water-insoluble residue of Agaricus blazei fruiting bodies. Carbohydr. Res., 186, 267-273.
9. Kerékgyártó, C., Virág, L., Tankó, L., Chihara, G. and Fachet, J. (1996). Strain differences in the cytotoxic activity and TNF production of murine macrophages stimulated by lentinan. Int. J. Immunopharmacol., 18, 347-353.
10. Ladányi, A., Tímár, J. and Lapis, K. (1993). Effect of lentinan on macrophage cytotoxicity against metastatic tumor cells. Cancer Immunol. Immunother., 36, 123-126.
11. Leung, M.Y. K., Fung, K. P. and Choy, Y.M. (1997). The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from Flammulina velutipes. Immunopharmacology, 35, 255-263.
12. Lorsbach, R. B., Murphy, W. J., Lowenstein, C. J., Snyder, S. H. and Russell, S.W. (1993). Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. J. Biol. Chem., 268, 1908-1913.
13. Lowenstein, C. J. and Snyder, S. H. (1992). Nitric oxide, a novel biologic messenger. Cell. 70, 705-707.
14. Maeda, Y. Y. and Chihara, G. (1973). The effects of neonatal thymectomy on the anti-tumor activity of lentinan, carboxymethyl pacymaran and Zymosan and their effects on various immune responses. Int. J. Cancer, 11, 153-161.
15. Mizuno, M., Yamada, J., Terai, H., Kozukue, N., Lee, Y.S. and Tsuchida, H. (1994). Differences in immunomodulating effects between wild and cultured Panax ginseng. Biochem. Biophy. Res. Commun., 200, 1672-1678.
16. Mizuno, M., Minato, K. and Tsuchida, H. (1996). Preparation and specificity of antibodies to an anti-tumor β-glucan, lentinan. Biochem. Mol. Biol. Int., 39, 679-685.
17. Mizuno, M., Morimoto, M., Minato, K. and Tsuchida, H. (1998). Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. Biosci. Biotechnol. Biochem., 62, 434-437.
18. Mizuno, M., Minato, K., Ito, H., Kawade, M., Terai, H. and Tsuchida, H. (1999). Anti-tumor polysaccharide from the mycelium of liquid-cultured Agaricus blazei Mill. Biochem. Mol. Biol. Int., 47, 707-714.
19. Mizuno, M., Yamakawa, A., Minato, K., Kawakami, S., Tatsuoka, S., Terai, H. and Tsuchida, H. (1999). Preparation of antibody against β-glucan in Grifola frondosa and its application. Food Sci. Technol. Res., 5, 398-401
20. Mizuno, M., Shiomi, Y., Minato, K., Kawakami, S., Ashida, H. and Tsuchida, H. (2000). Fucogalactan isolated from Sarcodon aspratus elicits release of tumor necrosis factor-α and nitric oxide from murine macrophages. Immunopharmacology, 46, 113-121.
21. Mizuno, T., Inagaki, R., Kanao, T., Hagiwara, T., Nakamura, T., Ito, H., Shimura, K., Sumiya, T. and Asakura, A. (1990). Anti-tumor activity and some properties of water-soluble polysaccharides from "Himematsutake," the fruiting body of Agaricus blazei Murill. Agric. Biol. Chem., 54, 2889-2896.
22. Nanba, H., Hamaguchi, A. and Kuroda, H. (1987). The chemical structure of an anti-tumor polysaccharide in fruit bodies of Grifola frondosa (Maitake). Chem. Pharm. Bull., 35, 1162-1168.
23. Nanba, H. and Kuroda, H. (1987). Anti-tumor mechanisms of orally administered shiitake fruit bodies. Chem. Pharm. Bull., 35, 2459-2464.
24. Novaes-Ledieu, M. and Garcia-Mendoza, C. (1981). The cell walls of Agaricus bisporus and Agaricus compestris fruiting body hyphae. Can. J. Microbiol., 27, 779-787.
25. Sasaki, T. and Takasuka, N. (1976). Further study of the structure of lentinan, an anti-tumor polysaccharide from Lentinus edodes. Carbohydr. Res., 47, 99-104.
26. Suzuki, I., Tanaka, H., Kinoshita, A., Oikawa, S., Osawa, M. and Yadomae, T. (1990). Effect of orally administered β-glucan on macrophage function in mice. Int. J. Immunopharmac., 12, 675-684.
27. Takeyama, T., Suzuki, I., Ohno, N., Oikawa, S., Sato, K., Ohsawa, M. and Yadomae, T. (1987). Host-mediated anti-tumor effect of grifolan NMF-5N, a polysaccharide obtained from Grifola frondosa. J. Pharmacobio dyn., 10, 644-651.
28. Xie, O.-W., Cho, H. J., Calaycay, J., Mumford, R. A., Swiderek, K. M., Lee, T. D., Ding, A., Troso, T. and Nathan, C. (1992). Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science, 256, 225-228.