Cytokine profile of Plasmodium falciparum-specific T cells in non-immune malaria patients

Parasite Immunology

Volumn 25, Issue 4, 2003, Pages 211-219

  Ramharter, Michael ^a,b   Willheim, Martin ^a   Winkler, Heidi ^a   Wahl, Katharina ^a   Lagler, Heimo ^a   Graninger, Wolfgang ^a   Winkler, Stefan ^a,c  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cytokines; Plasmodium falciparum; T cells

Indexed keywords

ATOVAQUONE PLUS PROGUANIL; CD3 ANTIGEN; CLINDAMYCIN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; MITOGENIC AGENT; QUININE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BRAIN MALARIA; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ERYTHROCYTE; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; MALARIA FALCIPARUM; MALE; PARASITE ISOLATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; ANIMALS; ANTIGENS, CD3; ANTIGENS, PROTOZOAN; CASE-CONTROL STUDIES; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MALARIA, CEREBRAL; MALARIA, FALCIPARUM; MALE; MIDDLE AGED; PLASMODIUM FALCIPARUM; T-LYMPHOCYTE SUBSETS; TUMOR NECROSIS FACTOR-ALPHA;

CINCHONA PUBESCENS; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0346880453     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.2003.00628.x     Document Type: Article

References (25)

1. Kwiatkowski D, Hill AV, Sambou I et al. TNF concentrations in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet 1990; 336: 1201-1204.
2. Harpaz R, Edelman R, Wasserman SS, Levine MM, Davies JR & Sztein MB. Serum cytokine profiles in experimental human malaria. J Clin Invest 1992; 90: 515-523.
3. Miller LH, Baruch DI, Marsh K, Doumbo OK. The pathogenic basis of malaria. Nature 2002; 415: 673-679.
4. Day NPJ, Tinh Hien T, Schollaardt T et al. The prognostic and pathophysiologic role of pro-and anti-inflammatory cytokines in severe malaria. J Infect Dis 1999; 180: 1288-1297.
5. Kurtzhals JAL, Adabayeri V, Goka BQ et al. Low plasma concentrations of interleukin 10 in severe malarial anaemia compared with cerebral and uncomplicated malaria. Lancet 1998; 351: 1768-1772.
6. Winkler S, Willheim M, Baier K et al. Reciprocal regulation of Th1-and Th2-cytokine-producing T cells during clearance of parasitemia in Plasmodium falciparum malaria. Infect Immun 1998; 66: 6040-6044.
7. Winkler S, Willheim M, Baier K et al. Frequency of cytokine-producing T cells in patients of different age groups with Plasmodium falciparum malaria. J Infect Dis 1999; 179: 209-216.
8. + T cells from non-exposed donors. Parasite Immunol 1994; 16: 579-586.
9. Dick S, Waterfall M, Currie J, Maddy A & Riley E. Naïve human αβ T cells respond to membrane-associated components of malaria-infected erythrocytes by proliferation and production of interferon-γ. Immunology 1996; 88: 412-420.
10. Hensmann M & Kwiatkowski D. Cellular basis of early cytokine response to Plasmodium falciparum. Infect Immun 2001; 69: 2364-2371.
11. Scragg IG, Hensmann M, Bate CA & Kwiatkowski D. Early cytokine induction by Plasmodium falciparum is not a classical endotoxin-like process. Eur J Immunol 1999; 29: 2636-2644.
12. Troye-Blomberg M, Berzins K & Perlmann P. T-cell control of immunity to the asexual stages of the malaria parasite. Crit Rev Immunol 1994; 14: 131-155.
13. Hviid L, Kurtzhals JAL, Goka BQ, Oliver-Commey JO, Nkrumah FK & Theander TG. Rapid reemergence of T cells into circulation following treatment of severe and uncomplicated Plasmodium falciparum malaria. Infect Immun 1997; 65: 4090-4093.
14. Kemp K, Akanmori BD, Adabayeri V et al. Cytokine production and apoptosis among T cells from patients under treatment for Plasmodium falciparum malaria. Clin Exp Immunol 2002; 127: 151-157.
15. Lell B & Kremsner PG. Clindamycin as an antimalarial drug: review of clinical trials. Antimicrob Agents Chemother 2002; 46: 2315-2320.
16. Van Kuppeveld FJ, van der Logt JT, Angulo AF et al. Genus-and species-specific identification of mycoplasmas by 16S rRNA amplification. Appl Environ Microbiol 1992; 58: 2606-2615.
17. Staalsoe T, Giha HA, Dodoo D, Theander TG & Hviid L. Detection of antibodies to variant antigens on Plasmodium falciparum-infected erythrocytes by flow cytometry. Cytometry 1999; 35: 329-336.
18. Crucian BE, Stowe RP, Pierson DL & Sams CF. Routine detection of Epstein-Barr virus specific T-cells in the peripheral blood by flow cytometry. J Immunol Meth 2001; 247: 35-47.
19. Suni MA, Picker LJ & Maino VC. Detection of antigen-specific cytokine expression in whole blood by flow cytometry. J Immunol Meth 1998; 212: 89-98.
20. Schwarzer E, Turrini F, Ulliers D, Giribaldi G, Ginsburg H & Arese P. Impairment of macrophage functions after ingestion of Plasmodium falciparum-infected erythrocytes or isolated malarial pigment. J Exp Med 1992; 176: 1033-1041.
21. Zevering Y, Amante F, Smillie A et al. High frequency of malaria-specific T cells in non-exposed humans. Eur J Immunol 1992; 22: 689-696.
22. Trinchieri G. Regulatory role of T cells producing both interferon γ and interleukin 10 in persistent infection. J Exp Med 2001; 194: F53-F57.
23. + T cells adaptively transferred into recipient mice after challenge with homologous parasite. Proc Natl Acad Sci USA 1998; 95: 1715-1720.
24. Good MF. Towards a blood-stage vaccine for malaria: are we following all the leads? Nat Rev Immunol 2001; 1: 117-125.
25. Riley EM. Is T-cell priming required for initiation of pathology in malaria infections? Immunol Today 1999; 20: 228-233.