Oestrogen-androgen crosstalk in the pathophysiology of erectile dysfunction

Asian Journal of Andrology

Volumn 5, Issue 4, 2003, Pages 307-313

  Srilatha, B ^a   Adaikan, P G ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Environmental oestrogen; Erectile dysfunction; Functional crosstalk; Oestrogen; Oestrogen receptor; Testosterone

Indexed keywords

ANDROGEN; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE; ORGANOCHLORINE DERIVATIVE; PHENOL DERIVATIVE; PHYTOESTROGEN; TESTOSTERONE;

AGING; AROMATIZATION; CORPUS CAVERNOSUM; CORRELATION ANALYSIS; ERECTILE DYSFUNCTION; ESTROGEN ACTIVITY; FOOD INTAKE; HOMEOSTASIS; HORMONE DEFICIENCY; HUMAN; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; IMPOTENCE; MALE; PATHOPHYSIOLOGY; PENIS ERECTION; PENIS NOCTURNAL TUMESCENCE; PLANT; PROGNOSIS; REVIEW; SEXUALITY;

AGED; AGING; ANDROGENS; ESTROGENS; HUMANS; HYPOGONADISM; IMPOTENCE; ISOFLAVONES; MALE; PHYTOESTROGENS; PLANT PREPARATIONS; TESTOSTERONE;

EID: 0346656589     PISSN: 1008682X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (78)

1. Korenman SG. New insights into erectile dysfunction: a practical approach. Am J Med 1998; 105: 135-44.
2. Schill WB. Fertility and sexual life of men after their forties and in older age. Asian J Androl 2001; 3: 1-7.
3. Ponholzer A, Plas E, Schatzl G, Jungwirth A, Madersbacher S. Association of DHEA-S and estradiol serum levels to symptoms of aging men. Aging Male 2002; 5: 233-8.
4. Lunenfeld B. Aging men - Challenges ahead. Asian J Androl 2001; 3: 161-8.
5. Gray A. Feldman HA, McKinlay JB, Longcope C. Age, disease and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab 1991; 73: 1016-25.
6. Feldman HA, Longcope C, Derby CA, Johannes CB, Araujo AB, Coviello AD, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 2002; 87: 589-98.
7. Berg JP. Oestrogens - essential for reproduction in males, too. Eur J Endocrinol 1998; 138: 497-8.
8. Oettel M. Is there a role for estrogens in the maintenance of men's health? Aging Male 2002; 5: 248-57.
9. Cohen PG. The role of estradiol in the maintenance of secondary hypogonadism in males in erectile dysfunction. Med Hypotheses 1998; 50: 331-3.
10. Sharpe RM. Do males rely on female hormones? Nature 1997; 390: 447-8.
11. Tserotas K, Merino G. Andropause and the aging male. Arch Androl 1998; 40: 87-93.
12. Levitsky AM, Owens NJ. Pharmacologic treatment of hyper-sexuality and paraphilias in nursing home residents. J Am Geriatr Soc 1999; 47: 231-4.
13. Goh VHH. A unique human model for the study of sex hormones and reproduction. Singapore J Obs Gyn 1999; 30: 1-8.
14. Merchenthaler I, Shughrue PJ. Estrogen receptor alpha versus beta: new estrogen responsive tissues and new potentials for HRT. In: Bellino FL, editor. Biology of menopause. New York: Springer; 2000. p 259-72.
15. Hess RA, Burnick D, Lee KH, Bahr J, Taylor JA, Korach KS, et al. A role for oestrogens in the male reproductive system. Nature 1997; 390: 509-12.
16. Oettel M. Estrogen substitution in men: facts and speculations. Abstract 3rd World Congress on the Aging Male 2002. p 99.
17. Thomas DB. Breast cancer in men. Epidemiol Rev 1993; 15: 220-31.
18. Stremmel W, Niederau C, Berger M, Kley HK, Kruskemper HL, Strohmeyer G. Abnormalities in estrogen, androgen and insulin metabolism in idiopathic hemochromatosis. Ann N Y Acad Sci 1988; 526: 209-23.
19. Heinig J, Jackisch C, Rody A, Koch O, Buechter D, Schneider HP. Clinical management of breast cancer in males: a report of four cases. Eur J Obstet Gynaecol Reprod Biol 2002; 102: 67-73.
20. Mineur P, De Cooman S, Hustin J, Verhoeven G, De Hertogh R. Feminizing testicular Leydig cell tumor: hormonal profile before and after unilateral orchidectomy. J Clin Endocrinol Metab 1987; 64: 686-91.
21. Veldhuis JD, Sowers JR, Rogol AD, Klein FA, Miller N, Dufau ML. Pathophysiology of male hypogonadism associated with endogenous hyperestrogenism. Evidence for dual defects in the gonadal axis. N Engl J Med 1985; 312: 1371-5.
22. Adlercreutz H, Mazur W. Phyto-oestrogens and western diseases. Ann Med 1997; 29: 95-120.
23. Danzo BJ. The effects of environmental hormones on reproduction. Cell Mol Life Sci 1998; 54: 1249-64.
24. Sohoni P, Sumpter JP. Several environmental oestrogens are also anti-androgens. J Endocrinol 1998; 158: 327-39.
25. Cheek AO, McLachlan JA. Environmental hormones and the male reproductive system. J Androl 1998; 19: 5-10.
26. Oliva A, Giami A, Multigner L. Environmental agents and erectile dysfunction: a study in a consulting population. J Androl 2002; 23: 546-50.
27. Srilatha B, Adaikan PG. Estrogen and phytoestrogen predispose to erectile dysfunction: do ER-α and ER-β in the cavernosum play a role? Urol 2003; in press.
28. Srilatha B, Adaikan PG, Ng SC. Evidence for oestrogen-mediated erectile dysfunction. Abstract 2nd Combined Annual Scientific Meeting, National University of Singapore 2000. p 65.
29. Adaikan PG, Srilatha B. Oestrogen-mediated hormonal imbalance precipitates erectile dysfunction. Int J Imp Res 2003; 15: 38-43.
30. Stephens FO. Phytoestrogens and prostate cancer: possible preventive role. Med J Austr 1997; 167: 138-40.
31. Tenover JL. Male hormone replacement therapy including "andropause". Endocrinol Metab Clin North Am 1998; 27: 969-87.
32. Winters SJ. Endocrine evaluation of testicular function. Endocrinol Metab Clin North Am 1994; 23: 709-23.
33. Schiavi RC, Schreiner-Engel P, White D, Mandeli J. The relationship between pituitary-gonadal function and sexual behaviour in healthy aging men. Psychosom Med 1991; 53: 363-74.
34. Andersson KE, Wagner G. Physiology of penile erection. Physiol Rev 1995; 75: 191-236.
35. Hart BL. Testosterone regulation of sexual reflexes in spinal male rats. Science 1967; 155: 1283-4.
36. Davidson JM, Stefanick ML, Sachs BD, Smith ER. Role of androgen in sexual reflexes of the male rat. Physiol Behav 1978; 21: 141-6.
37. Gray GD, Smith ER, Davidson JM. Hormonal regulation of penile erection in castrated male rats. Physiol Behav 1980; 24: 463-8.
38. Scaletta L, Hull E. Systemic or intracranial apomorphine increases copulation in long-term castrated male rats. Pharmacol Biochem Behav 1990; 37: 471-5.
39. Heaton JP, Varrin SJ. Effects of castration and exogenous testosterone supplementation in an animal model of penile erection. J Urol 1994; 151: 797-800.
40. Zvara P, Sioufi R, Schipper HM, Begin LR, Brock GB. Nitric oxide mediated erectile activity is a testosterone dependent event: a rat erection model. Int J Imp Res 1995; 7: 209-19.
41. Weiner CP, Lizasoain I, Baylis SA, Knowles RG, Charles IG, Moncada S. Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc Natl Acad Sci USA 1994; 91: 5212-6.
42. Chamnesss SL, Ricker DD, Crone JK, Dembeck CL, Maguire MP, Burnett AL, et al. The effect of androgen on nitric oxide synthase in the male reproductive tract of the rat. Fertil Steril 1995; 63: 1101-7.
43. Traish AM, Munarriz R, O'Connell L, Choi S, Kim SW, Kim NN, et al. Effects of medical or surgical castration on erectile function in an animal model. J Androl 2003; 24: 381-7.
44. Adaikan PG, Bayasgalan G, Lau LC, Ng SC. Effect of testosterone and growth hormone on sexual function in aged male rats. Abstract 1st Asian ISSAM Meeting on the Aging Male, Malaysia 2001. p 68.
45. Adaikan PG, Chan CLK, Ng SC. Sexuality in the aging male. Abstract 14 th World Congress of Sexology, Hong Kong 1999. p 240.
46. Ellis WJ, Grayhack JT. Sexual function in aging males after orchidectomy and estrogen therapy. J Urol 1963; 89: 895-9.
47. Buena F, Swerdloff RS, Steiner BS, Lutchmansingh P, Peterson MA, Pandian MR, et al. Sexual function does not change when serum testosterone levels are pharmacologically varied within the normal male range. Fertil Steril 1993; 59: 1118-23.
48. Gooren LJ. A ten-year safety study of the oral androgen testosterone undecanoate. J Androl 1994; 15: 212-5.
49. Morales A, Johnston B, Heaton JWP, Clark A. Oral androgens in the treatment of hypogonadal impotent men. J Urol 1994; 152: 1115-8.
50. Bancrofti J. Hormones and human sexual behaviour. J Sex Marital Ther 1984; 10: 3-21.
51. Magoha GA. Effect of ageing on androgen levels in elderly males. East Afr Med J 1997; 74: 642-4.
52. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 1994; 331: 1056-61.
53. Faustini-Fustini M, Rochira V, Carani C. Oestrogen deficiency in men: where are we today? Eur J Endocrinol 1999; 140: 111-29.
54. Srilatha B, Adaikan PG: Immunohistochemical identification of estrogen receptors in corpus cavernosum. Abstract 8th Asia-Pacific Society for Impotence Research & Exhibition (APSIR) 2001. p 167.
55. Green S, Walter P, Kumar V, Krust A, Bornert JM, Argos P, et al. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 1986; 320: 134-9.
56. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA. Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 1996; 93: 5925-30.
57. Menuet A, Pellegrini E, Anglade I, Blaise O, Laudet V, Kah O, et al. Molecular characterization of three estrogen receptor forms in zebrafish: binding characteristics, transactivation properties, and tissue distributions. Biol Reprod 2002; 66: 1881-92.
58. Miller G. Endocrinology: divorcing estrogen's bright and dark sides. Science 2002; 298: 723-4.
59. Valenta LJ, Elias AN. Male hypogonadism due to hyperestrogenism. N Engl J Med 1986; 314: 186.
60. Valenta LJ. A syndrome of functional hypogonadotropic hypogonadism and sterility in a male with elevated serum estradiol. Fertil Steril 1977; 28: 881-4.
61. Itoh N, Kumamoto Y, Maruta H, Tsukamoto T, Takagi Y, Mikuma N, et al. Therapeutic efficacy of testolactone (aromatase inhibitor) to oligozoospermia with high estradiol/testosterone ratio. Nippon Hinyokika Gakkai Zasshi 1991; 82: 204-9.
62. Hess RA, Bunick D, Bahr JM. Sperm, a source of estrogen. Environ Health Perspect 1995; 103: 59-62.
63. Edwards JC. Letter: Estrogen and impotence. Can Med Assoc J 1976; 114: 498.
64. O'Regan JB. Letter: Estrogen and impotence. Can Med Assoc J 1976; 114: 1090-4.
65. McSherry JA. Letter: Estrogen and impotence. Can Med Assoc J 1976; 114: 1090-4.
66. Carani C, Rochira V, Faustini-Fustini M, Balestrieri A, Granata AR. Role of oestrogen in male sexual behaviour: insights from the natural model of aromatase deficiency. Clin Endocrinol 1999; 51: 517-24.
67. Ogawa S, Lubahn DB, Korach KS, Pfaff DW. Behavioural effects of estrogen receptor gene disruption in male mice. Neurobiol Proc Natl Acad Sci USA 1997; 94: 1476-81.
68. Scordalakes EM, Imwalle DB, Rissman EF. Oestrogen's masculine side: mediation of mating in male mice. Reproduction 2002; 124: 331-8.
69. Gill-Sharma MK, Dsouza S, Padwal V, Balasinor N, Aleem M, Parte P, et al. Antifertility effects of estradiol in adult male rats. J Endocrinol Invest 2001; 24: 598-607.
70. Turner KJ, Sharpe RM. Environmental oestrogens - present understanding. Rev Reprod 1997; 2: 69-73.
71. Brzezinski A, Debi A. Phytoestrogens: the "natural" selective estrogen receptor modulators? Eur J Obstet Gynecol Reprod Biol 1999; 85: 47-51.
72. Webb M, Glasier A. Phyto-oestrogens for the treatment of menopausal symptoms. IPPF Med Bull 2001; 35: 3.
73. Dornstauder E, Jisa E, Unterrieder I, Krenn L, Kubelka W, Jungbauer A. Estrogenic activity of two standardized red clover extracts (Menoflavon) intended for large scale use in hormone replacement therapy. J Steroid Biochem Mol Biol 2001; 78: 67-75.
74. Ginsburg J, Prelevic GM. Lack of significant hormonal effects and controlled trials of phyto-oestrogens. Lancet 2000; 355: 163-4.
75. Santti R, Makela S, Strauss L, Korkman J, Kostian ML. Phytoestrogens: potential endocrine disruptors in males. Toxicol Ind Health 1998; 14: 223-37.
76. Setchell KD. Phytoestrogens: the biochemistry, physiology and implications for human health of soy isoflavones. Am J Clin Nutr 1998; 68: 1333S-46S.
77. Nicholls J, Lasley BL, Nakajima ST, Setchell KD, Schneeman BO. Effects of soy consumption on gonadotropin secretion and acute pituitary responses to gonadotropin-releasing hormone in women. J Nutr 2002; 132: 708-14.
78. Setchell KD. Soy isoflavones: benefits and risks from nature's selective estrogen receptor modulators (SERMs). J Am Coll Nutr 2001; 20: 354S-62S.