A nucleotide insertion in the transcriptional regulatory region of FADS2 gives rise to human fatty acid delta-6-desaturase deficiency

Journal of Lipid Research

Volumn 44, Issue 12, 2003, Pages 2311-2319

  Nwankwo, Joseph O ^a   Spector, Arthur A ^a   Domann, Frederick E ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

CCAAT enhancer binding protein; Fatty acid metabolism; Gene expression; Insertion polymorphism; Polyunsaturated fatty acid

Indexed keywords

ACYL COENZYME A DESATURASE; FATTY ACID DELTA6 DESATURASE; LINOLEOYL COENZYME A DESATURASE; MESSENGER RNA; NUCLEOTIDE; POLYUNSATURATED FATTY ACID; THYMIDINE; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME DEFICIENCY; FATTY ACID DELTA6 DESATURASE DEFICIENCY; FATTY ACID SYNTHESIS; GENE INSERTION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SKIN FIBROBLAST; STEADY STATE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TRANSLATION INITIATION;

3T3 CELLS; ANIMALS; BASE SEQUENCE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FATTY ACID DESATURASES; FIBROBLASTS; HUMANS; LINOLEOYL-COA DESATURASE; MICE; MUTAGENESIS, INSERTIONAL; PROMOTER REGIONS (GENETICS); RATS; REGULATORY SEQUENCES, NUCLEIC ACID; RNA STABILITY; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID; SKIN; TRANSCRIPTION, GENETIC;

EID: 0346463259     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M300273-JLR200     Document Type: Article

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