Interleukin-3 in Cooperation with Transforming Growth Factor β Induces Granulocyte Macrophage Colony Stimulating Factor Independent Differentiation of Human CD34+ Hematopoietic Progenitor Cells into Dendritic Cells with Features of Langerhans Cells

Journal of Investigative Dermatology

Volumn 121, Issue 6, 2003, Pages 1397-1401

  Mollah, Zia U A ^a   Aiba, Setsuya ^a   Nakagawa, Satoshi ^a   Mizuashi, Masato ^a   Ohtani, Tomoyuki ^a   Yoshino, Yumiko ^a   Tagami, Hachiro ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Birbeck granules; Dendritic cells; Hematopoietic progenitor cells; Interleukin 3; Langerhans cells

Indexed keywords

CADHERIN; CD34 ANTIGEN; CYTOKINE; F CADHERIN; FLT3 LIGAND; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; LANGERIN; PROTEIN; STEM CELL FACTOR; T6 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLOGENEIC RESTRICTION; ALLOGENEIC T CELL STIMULATION; ARTICLE; BIRBECK GRANULE; CELL CULTURE; CELL DIFFERENTIATION; CELL GRANULE; CELL MATURATION; CELL POLARITY; CELL STIMULATION; CONTROLLED STUDY; CULTURE MEDIUM; DENDRITIC CELL; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LANGERHANS CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

EID: 0346363877     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1523-1747.2003.12641.x     Document Type: Article

References (20)

1. Borkowski TA, Letterio JJ, Mackall CL, et al: A role for TGFβ1 in Langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFβ1 null mice. J Clin Invest 100:575-581, 1997
2. Buelens C, Bartholome EJ, Amraoui Z, et al: Interleukin-3 and interferon β cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties. Blood 99:993-998, 2002
3. Burnham K, Robb L, Scott CL, O'Keeffe M, Shortman K: Effect of granulocyte-macrophage colony-stimulating factor on the generation of epidermal Langerhans cells. J Interferon Cytokine Res 20:1071-1076, 2000
4. Caux C, Vanbervliet B, Massacrier C, Durand I, Banchereau J: Interleukin-3 cooperates with tumor necrosis factor α for the development of human dendritic/ Langerhans cells from cord blood CD34+ hematopoietic progenitor cells. Blood 87:2376-2385, 1996
5. Caux C, Massacrier C, Dubois B, et al: Respective involvement of TGF-β and IL-4 in the development of Langerhans cells and non-Langerhans dendritic cells from CD34+ progenitors. J Leukocyte Biol 66:781-791, 1999
6. Ebner S, Hofer S, Nguyen VA, et al: A novel role for IL-3: Human monocytes cultured in the presence of IL-3 and IL-4 differentiate into dendritic cells that produce less IL-12 and shift Th cell responses toward a Th2 cytokine pattern. J Immunol 168:6199-6207, 2002
7. Flanagan AM, Lader CS: Update on the biologic effects of macrophage colony-stimulating factor. Curr Opin Hematol 5:181-185, 1998
8. Gatti E, Velleca MA, Biedermann BC, et al: Large-scale culture and selective maturation of human Langerhans cells from granulocyte colony-stimulating factor-mobilized CD34+ progenitors. J Immunol 164:3600-3607, 2000
9. Geissmann F, Prost C, Monnet JP, Dy M, Brousse N, Hermine O: Transforming growth factor β1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells. J Exp Med 187:961-966, 1998
10. Grouard G, Rissoan MC, Filgueira L, Durand I, Banchereau J, Liu YJ: The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med 185:1101-1111, 1997
11. Ito T, Inaba M, Inaba K, et al: A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells. J Immunol 163:1409-1419, 1999
12. Larregina AT, Morelli AE, Spencer LA, Logar AJ, Watkins SC, Thomson AW, Falo LD Jr: Dermal-resident CD14+ cells differentiate into Langerhans cells. Nat Immunol 2:1151-1158, 2001
13. Miyajima A, Mui AL, Ogorochi T, Sakamaki K: Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Blood 82:1960-1974, 1993
14. Mollah ZU, Aiba S, Manonie H, Yoshino Y, Tagami H: Cord blood CD34+ cells differentiate into dermal dendritic cells in co-culture with cutaneous fibroblasts or stromal cells. J Invest Dermatol 118:450-460, 2002
15. Mollah Z, Aiba S, Nakagawa S, et al: M-CSF in cooperation with transforming growth factor-β1 induces the differentiation of CD34+ hematopoietic progenitor cells into Langerhans cells under serum-free conditions without GM-CSF. J Invest Dermatol 120:256-265, 2003
16. Riedl E, Strobl H, Majdic O, Knapp W: TGF-β1 promotes in vitro generation of dendritic cells by protecting progenitor cells from apoptosis. J Immunol 158:1591-1597, 1997
17. Strobl H, Riedl E, Scheinecker C, Bello-Fernandez C, Pickl WF, Rappersberger K, Majdic O, Knapp W: TGF-β1 promotes in vitro development of dendritic cells from CD34+ hemopoietic progenitors. J Immunol 157:1499-1507, 1996
18. Valladeau J, Ravel O, Dezutter-Dambuyant C, et al: Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12:71-81, 2000
19. Vremec D, Lieschke GJ, Dunn AR, Robb L, Metcalf D, Shortman K: The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs. Eur J Immunol 27:40-44, 1997
20. Witmer-Pack MD, Hughes DA, Schuler G, et al: Identification of macrophages and dendritic cells in the osteopetrotic (op/op) mouse. J Cell Sci 104:1021-1029, 1993