Macrophage colony-stimulating factor in cooperation with transforming growth factor-β1 induces the differentiation of CD34+ hematopoietic progenitor cells into Langerhans cells under serum-free conditions without granulocyte-macrophage colony-stimulating factor

Journal of Investigative Dermatology

Volumn 120, Issue 2, 2003, Pages 256-265

  Mollah, Zia U A ^a   Aiba, Setsuya ^a   Nakagawa, Satoshi ^a   Hara, Masahiro ^a   Manome, Hideaki ^a   Mizuashi, Masato ^a   Ohtani, Tomoyuki ^a   Yoshino, Yumiko ^a   Tagami, Hachiro ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antigen presentation or processing; Cellular differentiation; Cytokines; Dendritic cells; Human

Indexed keywords

CD11 ANTIGEN; CD34 ANTIGEN; COLONY STIMULATING FACTOR 1; FLT3 LIGAND; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; STEM CELL FACTOR; T6 ANTIGEN; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UVOMORULIN; ANTINEOPLASTIC AGENT; FLT3 LIGAND PROTEIN; GLYCOPROTEIN P 15095; MEMBRANE PROTEIN; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; LANGERHANS CELL; PHENOTYPE; PRIORITY JOURNAL; STEM CELL; T LYMPHOCYTE; CELL AGING; CHEMISTRY; CULTURE MEDIUM; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; IMMUNOPHENOTYPING; METHODOLOGY;

ANTIGENS, CD11C; ANTIGENS, CD34; ANTINEOPLASTIC AGENTS; CELL AGING; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; FLOW CYTOMETRY; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOPHENOTYPING; LANGERHANS CELLS; MACROPHAGE COLONY-STIMULATING FACTOR; MEMBRANE PROTEINS; STEM CELL FACTOR; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037289788     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2003.12036.x     Document Type: Article

References (42)

1. Aiba S: Maturation of dendritic cells induced by cytokines and haptens. Tohoku J Exp Med 184:159-172, 1998
2. Banchereau J, Steinman RM: Dendritic cells and the control of immunity. Nature 392:245-252, 1998
3. Bernhard H, Disis ML, Heimfeld S, Hand S, Gralow JR, Cheerer MA: Generation of immunostimulatory dendritic cells from human CD34 + hematopoietic progenitor cells of the bone marrow and peripheral blood. Cancer Res 55:1099-1104, 1995
4. Borkowski TA, Letterio JJ, Mackall CL, et al A role for TGFbeta1 in Langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGF-beta1 null mice. J Clin Invest 100:575-581, 1997
5. Burnham K, Robb L, Scott CL, O'Keeffe M, Shortman K: Effect of granulocyte-macrophage colony-stimulating factor on the generation of epidermal Langerhans cells. J Interferon Cytokine Res 20:1071-1076, 2000
6. Canque B, Camus S,Yagello M, Gluckman JC: IL-4 and CD40 ligation affect differently the differentiation, maturation, and function of human CD34 + cell-derived CD1a + CD14- and CD1a-CD14 + dendritic cell precursors in vitro. J Leukocyte Biol 64:235-244, 1998
7. Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J: GM-CSF and TNF- αcooperate in the generation of dendritic Langerhans cells. Nature 360:258-261, 1992
8. Caux C, Massacrier C, Dubois B, et al Respective involvement of TGF-beta and IL-4 in the development of Langerhans cells and non-Langerhans dendritic cells from CD34 + progenitors. J Leukocyte Biol 66:781-791, 1999
9. Caux C, Vanbervliet B, Massacrier C, et al CD34 + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNFalpha. J Exp Med 184:695-706, 1996a
10. Caux C, Vanbervliet B, Massacrier C, Durand I, Banchereau J: Interleukin-3 cooperates with tumor necrosis factor alpha For the development of human dendritic/Langerhans cells from cord blood CD34 + hematopoietic progenitor cells. Blood 87:2376-2385, 1996b
11. Dalloul AH, Patty C, Salamero J, Canque B, Grassi E Schmitt C: Functional and phenotypic analysis of thymic CD34 + CD1a- progenitor-derived dendritic cells: predominance of CD1a + differentiation pathway. J Immunol 162:5821-5828, 1999
12. Gatti E, Velleca MA, Biedermann BC, et al Large-scale culture and selective maturation of human Langerhans cells from granulocyte colony-stimulating factor-mobilized CD34 + progenitors. J Immunol 164:3600-3607, 2000
13. Herbst B, Kohler G, Mackensen A, et al In vitro differentiation oF CD34 + hematopoietic progenitor cells toward distinct dendritic cell subsets of the Birbeck granule and MIIC-positive Langerhans cell and the interdigitating dendritic cell type. Blood 88:2541-2548, 1996
14. Inaba K, Inaba M, Romani N, et al Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-simulating factor. J Exp Med 176:1693-1702, 1992
15. Inaba K, Inaba M, Deguchi M, et al Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow. Proc Natl Acad Sci USA 90:3038-3042, 1993
16. Ito T, Inaba M, Inaba K, et al A CD1a + /CD11c + subset of human blood dendritic cells is a direct precursor of Langerhans cells. J Immunol 163:1409-1419, 1999
17. Jaksits S, Kriehuber E, Charbonnier AS, Rappersberger K, Stingl G, Maurer D: CD34 + cell-derived CD14 + precursor cells develop into Langerhans cells in a TGF-beta 1-dependent manner. J Immunol 163:4869-4877, 1999
18. Kamps AW, Hendriks D, Smit JW, Vellenga E: Role of macrophage colony-stimulating factor in the differentiation and expansion of monocytes and dendritic cells from CD34 + progenitor cells. Med Oncol 16:46-52, 1999
19. Menetrier-Caux C, Montmain G, Dieu MC, Bain C, Favrot MC, Caux C, Blay JY: Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor. Blood 92:4778-4791, 1998
20. Metlay JP, Witmer-Pack MD, Agger R, Crowley MT, Lawless D, Steinman RM: The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J Exp Med 171:1753-1771, 1990
21. Mollah ZU, Aiba S, Manome H, Yoshino Y, Tagami H: Cord blood CD34 + cells differentiate into dermal dendritic cells in co-culture with cutaneous fibroblasts or stromal cells. J Invest Dermatol 118:450-460, 2002
22. Reid CD, Stackpoole A, Meager A, Tikerpae J: Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34 + progenitors in human bone marrow. J Immunol 149:2681-2688, 1992
23. Riedl E, Strobl H, Majdic O, Knapp W: TGF-beta 1 promotes in vitro generation of dendritic cells by protecting progenitor cells from apoptosis. J Immunol 158:1591-1597, 1997
24. Rissoan MC, Soumelis V, Kadowaki N, Grouard G, Briere F, de Waal Malefyt R, Liu YJ: Reciprocal control of T helper cell and dendritic cell differentiation. Science 283:1183-1186, 1999
25. Romani N, Bruner S, Brang D, et al Proliferating dendritic cell progenitors in human blood. J Exp Med 180:83-93, 1994
26. Rosenzwajg M, Canque B, Gluckman JC: Human dendritic cell differentiation pathway from CD34 + hematopoietic precursor cells. Blood 87:535-544, 1996
27. Sallusto F, Cella M, Danieli C, Lanzavecchia A: Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histo-compatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med 182:389-400, 1995
28. Santiago-Schwarz F, Belilos E, Diamond B, Carsons SE: TNF in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages. J Leukocyte Biol 52:274-281, 1992
29. Siena S, Di Nicola M, Bregni M, et al Massive ex vivo generation of functional dendritic cells from mobilized CD34 + blood progenitors for anticancer therapy. Exp Hematol 23:1463-1471, 1995
30. Strobl H, Riedl E, Scheinecker C, et al TGF-beta 1 promotes in vitro development of dendritic cells from CD34 + hemopoietic progenitors. J Immunol 157:1499-1507, 1996
31. Strobl H, Bello-Fernandez C, Riedl E, Pickl WF, Majdic O, Lyman SD, Knapp W: flt3 ligand in cooperation with transforming growth factor-beta1 potentiates in vitro development of Langerhans-type dendritic cells and allows single-cell dendritic cell cluster formation under serum-free conditions. Blood 90:1425-1434, 1997
32. Strunk D, Rappersberger K, Egger C. et al Generation of human dendritic cells/Langerhans cells from circulating CD34 + hematopoietic progenitor cells. Blood 87:1292-1302, 1996
33. Szabolcs P, Moore MA, Young JW: Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34 + bone marrow precursors cultured with c-kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-alpha. J Immunol 154:5851-5861, 1995
34. Szabolcs P, Avigan D, Gezelter S, Ciocon DH, Moore MA, Steinman RM, Young JW: Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-colony-forming unit intermediate. Blood 87:4520-4530, 1996
35. Takahashi K, Naito M, Morioka Y, Schultz LD: Immunophenotypic and ultrastructural differentiation and maturation of nonlymphoid dendritic cells in osteopetrotic (op) mice with the total absence of macrophage colony stimulating factor activity. Adv Exp Med Biol 329:293-297, 1993
36. Takashima A, Edelbaum D, Kitajima T, et al Colony-stimulating factor-1 secreted by fibroblasts promotes the growth of dendritic cell lines (XS series) derived from murine epidermis. J Immunol 154:5128-5135, 1995
37. Usuda H, Naito M, Umeda S, Takahashi K, Shultz LD: Ultrastructure of macrophages and dendritic cells in osteopetrosis (op) mutant mice lacking macrophage colony-stimulating factor (M-CSF/CSF-1) activity. J Submicroscopic Cytol Pathol 26:111-119, 1994
38. Vremec D, Lieschke GJ, Dunn AN, Robb L, Metcalf D, Shortman K: The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs. Eur J Immunol 27:40-44, 1997
39. Witmer-Pack MD, Hughes DA, Schuler G, et al Identification of macrophages and dendritic cells in the osteopetrotic (op/op) mouse. J Cell Sci 104:1021-1029, 1993
40. Xu S, Ariizumi K, Caceres DG, Edelbaum D, Hashimoto K, Bergstresser PK, Takashima A: Successive generation of antigen-presenting, dendritic cell lines from routine epidermis. J Immunol 154:2697-2705, 1995
41. Young JW: Dendritic cells expansion and differentiation with hematopoietic growth factors. Curr Opinion Hematol 6:135-144, 1999
42. Young JW, Szabolcs P, Moore MA: Identification of dendritic cell colony forming units among normal human CD34 + bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha. J Exp Med 182:1111-1119, 1995