Functional group I metabotropic glutamate receptors in submucous plexus of guinea-pig ileum

British Journal of Pharmacology

Volumn 128, Issue 8, 1999, Pages 1631-1635

  Hu, Hong Zhen ^a   Ren, Jun ^a   Liu, Sumei ^a   Gao, Chuanyun ^a   Xia, Yun ^a   Wood, Jackie D ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Enteric nervous system; Intestinal secretion; Metabotropic glutamate receptors; Small intestine; Submucous plexus

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 CARBOXYPHENYLGLYCINE; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; DIZOCILPINE; GLUTAMATE RECEPTOR; METABOTROPIC RECEPTOR; QUISQUALIC ACID; RECEPTOR SUBTYPE; TETRODOTOXIN;

ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; GUINEA PIG; ILEUM; INTESTINE INNERVATION; MALE; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; RECEPTOR DENSITY;

EID: 0033457958     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702980     Document Type: Article

References (12)

1. CHRISTOFI, F.L. & WOOD, J.D. (1993). Effects of PACAP on morphologically identified myenteric neurons in guinea-pig small bowel. Am. J. Physiol., 264, G414-G421.
2. CONGAR, P., LEINEKUGEL, X., BEN-ARI, Y. & CREPEL, V.A. (1997). Long-lasting calcium-activated nonselective cationic current is generated by synaptic stimulation or exogenous activation of group I metabotropic glutamate receptors in CA1 pyramidal neurons. J. Neurosci., 17, 5366-5379.
3. CONN, P.J. & PIN, J.-P. (1997). Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol., 37, 205-237.
4. JANKOVIC, S.M., MILOVANOVIC, D., MATOVIC, M. & IRIC-CUPIC, V. (1999). The effects of excitatory amino acids on isolated gut segments of the rat. Pharmacol. Res., 39, 143-148.
5. KIRCHGESSNER, A.L., LIU, M.-T. & ALCANTARA, F. (1997). Excitotoxicity in the enteric nervous system. J. Neurosci., 17, 8804-8815.
6. LIU, M.-T., ROTHSTEIN, J.D., GERSHON, M.D. & KIRCHGESSNER, A.L. (1997). Glutamatergic enteric neurons. J. Neurosci., 17, 4764-4784.
7. OKUMA, Y., YOKOTANI, K, NAKAMURA, K & OSUMI, Y. (1996). Calcium-dependent release of endogenous glutamate from vascularly perfused rat stomach in vitro. J. Neurosci. Res., 44, 507-511.
8. RHOADS, J.M., ARGENZIO, R.A., CHEN, W., GOMEZ, G.G. (1995). Asparagine stimulates piglet intestinal Cl secretion by a mechanism requiring a submucosal glutamate receptor and nitric oxide. J Pharmacol. Exp. Ther., 274, 404-412.
9. SHEN, K.Z. & SURPRENANT, A. (1993). Common ionic mechanisms of excitation by substance P and other transmitters in guinea-pig submucosal neurones. J. Physiol. (London), 462, 483-501.
10. SINSKY, M. & DONNERER, J. (1998). Evidence for a neurotransmitter role of glutamate in guinea-pig myenteric plexus neurons. Neurosci. Lett., 258, 109-112.
11. WOOD, J.D. (1994). Physiology of the enteric nervous system. In: Physiology of the gastrointestinal tract, Ed 3. Johnson LR, Alpers DH, Jacobson ED, Walsh JH, (eds). pp. 423-482. New York: Raven.
12. ZAFIROV, D.H., COOKE, H.J. & WOOD, J.D. (1993). Elevation of cAMP facilitates noradrenergic transmission in submucous neurons of guinea-pig ileum. Am. J. Physiol., G442-G446.