Chromosomal Aberrations and Micronuclei in Lymphocytes of Breast Cancer Patients after an Accident during Radiotherapy with 8 MeV Electrons

Radiation Research

Volumn 160, Issue 6, 2003, Pages 677-683

  Wojcik, Andrzej ^a,b   Stephan, Günther ^c   Sommer, Sylwester ^a   Buraczewska, Iwona ^a   Kuszewski, Tomasz ^d   Wieczorek, Andrzej ^d   Gózdz, Stanislaw ^d  

^a INSTITUTE OF NUCLEAR CHEMISTRY AND TECHNOLOGY   (Poland)

^b JAN KOCHANOWSKI UNIVERSITY   (Poland)

^c BUNDESAMT FÜR STRAHLENSCHUTZ   (Germany)

^d Swietokrzyskie Centrum Onkologii Poland   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUOROURACIL; METHOTREXATE; NAVELBINE; VINCRISTINE;

ADULT; AGED; ARTICLE; BREAST CANCER; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRON RADIATION; HUMAN; LYMPHOCYTE; MICRONUCLEUS; PRIORITY JOURNAL; RADIATION ACCIDENT; RADIATION EXPOSURE;

ACCIDENTS, RADIATION; ADULT; BREAST NEOPLASMS; CHROMOSOME ABERRATIONS; ELECTRONS; FEMALE; HUMANS; LYMPHOCYTES; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MIDDLE AGED;

EID: 0346123216     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3090     Document Type: Article

References (26)

1. IAEA, Biological Dosimetry: Chromosomal Aberration Analysis for Dose Assessment. Technical Reports Series No. 260, IAEA, Vienna, 1986.
2. M. A. Bender, A. A. Awa, A. L. Brooks, H. J. Evans, P. G. Groer, L. G. Littlefield, C. Pereira, R. J. Preston and B. W. Wachholz, Current status of cytogenetic procedures to detect and quantify previous exposures to radiation. Mutat. Res. 196, 103-159 (1988).
3. S. Matsubara, M. S. Sasaki and T. Adachi, Dose-response relationship of lymphocyte chromosome aberrations in locally irradiated persons. J. Radiat. Res. 15, 189-196 (1974).
4. G. Obe, W. Matthiessen and D. Göbel, Chromosomal aberrations in peripheral lymphocytes of cancer patients treated with high-energy electrons and bleomycin. Mutat. Res. 81, 133-141 (1981).
5. J-L. Antoine, G. B. Gerber, A. Leonard, F. Richard and A. Wambersie, Chromosome aberrations induced in patients treated with telecobalt therapy for mammary carcinoma. Radiat. Res. 86, 171-177 (1981).
6. A. Diener, G. Stephan, T. Vogl and J. Lissner, The induction of chromosome aberrations during the course of radiation therapy for Morbus Hodgkin. Radiat. Res. 114, 528-536 (1988).
7. R. A. Kleinerman, L. G. Littlefield, R. E. Tarone, S. G. Machado, M. Blettner, L. J. Peters and J. D. Boice, Chromosome aberrations in peripheral lymphocytes and radiation dose to active bone marrow in patients treated for cancer of the cervix. Radiat. Res. 119, 176-190 (1989).
8. M. Fenech, J. Denham, W. Francis and A. A. Morley, Micronuclei in cytokinesis-blocked lymphocytes of cancer patients following fractionated partial-body radiotherapy. Int. J. Radiat. Biol. 57, 373-383 (1990).
9. I. Vorobtsova, F. Darroudi, A. Semyonov, A. Kanayeva, N. Timofeyeva, T. Yakovleva, G. Zharinov and A. T. Natarajan, Analysis of chromosome aberrations by FISH and Giemsa assays in lymphocytes of cancer patients undergoing whole-body irradiation: Comparison of in vivo and in vitro irradiation. Int. J. Radiat. Biol. 77, 1123-1131 (2001).
10. H. Thierens, A. Vral, M. van Eijkeren, F. Speleman and L. de Ridder, Micronucleus induction in peripheral blood lymphocytes of patients under radiotherapy treatment for cervical cancer or Hodgkin's disease. Int. J. Radiat. Biol. 67, 529-539 (1995).
11. J. le Roux, J. Slabbert and G. Blekkenhorst, Assessment of the micronucleus assay as a biological dosimeter using cytokinesis-blocked lymphocytes from cancer patients receiving fractionated partial-body radiotherapy. Strahlenther. Onkol. 174, 75-81 (1998).
12. P. Venkatachalam, F. D. P. Solomon, B. K. Prabhu, M. N. Mohankumar, N. Gajendiran and R. K. Jeevanram, Estimation of dose in cancer patients treated with fractionated radiotherapy using translocation, dicentrics and micronuclei frequency in peripheral blood lymphocytes. Mutat. Res. 429, 1-12 (1999).
13. T-K. Lee, K. F. O'Brien, J. L. Naves, K. I. Christie, H. H. Arastu, G. S. Eaves, A. L. Wiley, Jr., U. L. Karlsson and M. R. Salehpour, Micronuclei in lymphocytes of prostate cancer patients undergoing radiation therapy. Mutat. Res. 469, 63-70 (2000).
14. H. E. Johns and J. R. Cunningham, The Physics of Radiology. Charles C. Thomas, Springfield, IL, 1983.
15. A. A. Edwards, D. C. Lloyd and R. J. Purrot, Radiation induced chromosome aberrations and the Poisson distribution. Radiat. Environ. Biophys. 16, 89-100 (1979).
16. L. Sachs, Angewandte Statistik, 6th ed. Springer Verlag, Berlin, Heidelberg and New York, 1984.
17. R. Huber, H. Braselmann, U. Kulka, V. Schumacher-Georgiadou, A. Bayerl, M. Molls and M. Bauchinger, Follow-up analysis of translocation and dicentric frequencies, measured by FISH-chromosome painting in breast cancer patients after partial-body radiotherapy with little bone marrow exposure. Mutat. Res. 446, 103-109 (1999).
18. W-U. Müller and C. Streffer, Micronucleus assays. Adv. Mutagen. Res. 5, 1-134 (1994).
19. M. Fenech, The in vitro micronucleus technique. Mutat. Res. 455, 81-95 (2000).
20. R. J. Purrot, N. Vulpis and D. C. Lloyd, The use of harlequin staining to measure delay in the human lymphocyte cell cycle induced by in vitro X-irradiation. Mutat. Res. 69, 275-282 (1980).
21. D. C. Lloyd, R. J. Purrot and G. W. Dolphin, Chromosome aberration dosimetry using human lymphocytes in stimulated partial body irradiation. Phys. Med. Biol. 18, 421-431 (1973).
22. J. R. K. Savage and G. Breckon, Chromosome aberration frequencies after partial-body irradiation of Syrian hamsters. Br. J. Radiol. 58, 1105-1110 (1985).
23. A. Wojcik, K. Bonk, W-U. Müller, G. Obe and C. Streffer, Do DNA double-strand breaks induced by Alu I lead to development of novel aberrations in the second and third posttreatment mitosis? Radiat. Res. 145, 119-127 (1996).
24. D. C. Lloyd, G. W. Dolphin, R. J. Purrot and P. A. Tipper. The effect of x-ray induced mitotic delay on chromosome aberration yields in human lymphocytes. Mutat. Res. 42, 401-412 (1977).
25. 0. Int. J. Radiat. Biol. 78, 765-772 (2002).
26. R. C. Ricks, The radiation-accident patient in the new millenium: Past history and future threats. In The Medical Basis for Radiation-Accident Preparedness (R. C. Ricks, M. E. Berger and M. O'Hara, Jr., Eds.). Parthenon, Boca Raton, FL, 2002.