Estimation of dose in cancer patients treated with fractionated radiotherapy using translocation, dicentrics and micronuclei frequency in peripheral blood lymphocytes

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 429, Issue 1, 1999, Pages 1-12

  Venkatachalam, P ^a   Solomon, F D Paul ^a   Prabhu, B Karthikeya ^a   Mohankumar, Mary N ^a   Gajendiran, N ^a   Jeevanram, R K ^a  

^a INDIRA GANDHI CENTRE FOR ATOMIC RESEARCH   (India)

Author keywords

Cancer patient; Dicentric; Lymphocyte; Micronucleus; Radiotherapy; Translocation

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; COBALT THERAPY; CONTROLLED STUDY; DICENTRIC CHROMOSOME; DOSE RESPONSE; DOSIMETRY; FEMALE; GAMMA RADIATION; GENOTOXICITY; HUMAN; HUMAN CELL; MALE; MICRONUCLEUS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RADIATION DOSE; UTERINE CERVIX CANCER;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CENTROMERE; CHROMOSOME ABERRATIONS; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GAMMA RAYS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOCYTES; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MIDDLE AGED; RADIATION DOSAGE; TRANSLOCATION, GENETIC; UTERINE CERVICAL NEOPLASMS;

EID: 0032839822     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(99)00096-2     Document Type: Article

References (24)

1. Matsubara S., Saski M.S., Adachi T. Dose-response relationship of lymphocyte chromosome aberrations in locally irradiated person. Radiat. Res. 15:1974;189-196.
2. Antoine J.L., Gerber G.B., Leonard A., Richard F., Wambersie A. Chromosome aberration in patients treated with telecobalt therapy for mammary carcinoma. Radiat. Res. 86:1981;171-177.
3. Obe G., Matthiessen W., Gobel D. Chromosomal aberration in the peripheral lymphocytes of cancer patients treated with high-energy electrons and bleomycin. Mutat. Res. 81:1981;133-141.
4. Kleinerman R.A., Littelfield L.G., Tarone R.E., Machado S.G., Blettner M., Peters L.J., Boice J.D. Chromosome aberrations in peripheral lymphocytes and radiation dose to active bone marrow in patients treated for cancer of the cervix. Radiat. Res. 119:1986;176-190.
5. Diener A., Stephen G., Vogl Th., Lissner J. The induction of chromosome aberrations during the course of radiation therapy for Morbus hodgkin. Radiat. Res. 114:1988;528-536.
6. Fenech M., Denham J., Francis W., Morely A. Micronuclei in cytokinesis blocked lymphocytes of cancer patients following fractionated partial-body radiotherapy. Int. J. Radiat. Biol. 57:1990;373-383.
7. Gantenberg H.W., Wuttke K., Streffer C., Muller W.U. Micronuclei in human lymphocytes irradiated in vitro or in vivo. Radiat. Res. 128:1991;276-281.
8. Catena C., Conti D., Parasacchi P., Marenco P., Bortolato B., Boutturi M., Leoni M., Portaluri M., Righ E. Micronuclei in cytokinesis blocked lymphocytes may predict patient response to radiotherapy. Int. J. Radiat. Biol. 70:1996;301-308.
9. Thierens H., Vral A., Van Eijkeren M., Spelman F., de Ridder L. Micronucleus induction in peripheral blood lymphocytes of patients under radiotherapy treatment for cervical cancer or Hodgkin's disease. Int. J. Radiat. Biol. 67:1995;529-539.
10. Matsuoka A., Yadama K., Hayashi M., Sofuni T. Chromosomal aberrations detected by chromosome painting in lymphocytes from cancer patients given high doses of therapeutic X-rays. J. Radiat. Res. 37:1996;257-265.
11. IAEA report, Biological dosimetry, chromosome aberration analysis for dose assessment, in: Technical Report Series, No. 260, IAEA, Vienna, 1986, pp. 1-69.
12. H.E. Johns, Introduction to Physics of Radiobiology, 2nd edn., 1961, pp. 353-357.
13. Solomon F.D. Paul, Venkatachalam P., Jeevanram R.K. A comparative study of synchronised and conventional methods on the micronucleus dose-response curve. Mutat. Res. 391:1997;91-98.
14. Fenech M.A., Morely A.A. Measurement of micronuclei in lymphocytes. Mutat. Res. 147:1985;29-36.
15. Countryman P.I., Heddle J.A. The production of MN from chromosome aberrations in irradiated culture of human lymphocytes. Mutat. Res. 41:1976;321-332.
16. Darfler M.N., Nisson P.E., Watkins P.C. Painting human chromosome by in situ hybridisation, Novel reagent system chromosome detection and analysis. Focus. 14:1992;2-7.
17. Lucas J.N., Awa A.A., Straume T., Poggensee M., Kodama Y., Nakano M., Ohtaki K., Weier H.U., Pinkel D., Gray J., Littlefield G. Rapid translocation frequency analysis in human decades after exposure to ionising radiation. Int. J. Radiat. Biol. 62:1992;53-63.
18. Savage J.R.K. Curve fitting by maximum likelihood method. Radiat. Bot. 15:1975;127-131.
19. A.A. Edwards, J.A. Dennis, Polyfit - a computer programme for fitting a specified degree of polynomial to data points. NRPB-MII (Last update of programme, 1990), 1973, pp. 1-18.
20. Lea D.E., Catcheside D.G. The mechanism of the induction by radiation of chromosome aberrations in Transcantia. J. Genet. 44:1942;216-245.
21. Jain S.C., Metha S.C., Kumar B., Reddy A.R., Natarajan A. Formulation of the reference Indian adult: anatomic and physiologic data. Health Phys. 68:1995;509-521.
22. Fernandez J.L., Campos A., Goyanes V., Losada C., Veiras C., Edwards A.A. X-ray biological dosimetry performed by selective painting of human chromosomes 1 and 2. Int. J. Radiat. Biol. 67:1995;295-302.
23. Lloyd D.C., Purrott R.J., Reeder E.J. The incidence of unstable chromosome aberrations in peripheral blood lymphocytes from unirradiated and occupationally exposed people. Mutat. Res. 72:1980;523-532.
24. Prosser J.S., Moquet J.E., Lloyd D.C., Edwards A.A. Radiation induction of micronuclei in human lymphocytes. Mutat. Res. 199:1988;37-45.