Practical Large-Scale Synthesis of Doripenem: A Novel 1β- Methylcarbapenem Antibiotic

Organic Process Research and Development

Volumn 7, Issue 6, 2003, Pages 846-850

  Nishino, Yutaka ^a   Kobayashi, Makoto ^a   Shinno, Taneyoshi ^a   Izumi, Kenji ^a   Yonezawa, Hiroshi ^a   Masui, Yoshiyuki ^a   Takahira, Masayuki ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1BETA METHYLCARBAPENEM DERIVATIVE; 4 METHYLANILINE; DORIPENEM; INORGANIC COMPOUND; PYRROLIDINE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CHROMATOGRAPHY; CRYSTAL; DRUG SYNTHESIS; EXTRACTION; POWDER; PURIFICATION;

EID: 0346104835     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op034088n     Document Type: Article

References (21)

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21. 2 increased solubility of compound 1 in the aqueous layer.