Efficient one-pot synthesis of the 2-aminocarbonylpyrrolidin-4-ylthio-containing side chain of the new broad-spectrum carbapenem antibiotic ertapenem

Journal of Organic Chemistry

Volumn 67, Issue 14, 2002, Pages 4771-4776

  Brands, Karel M J ^a   Jobson, Ronald B ^a   Conrad, Karen M ^a   Williams, J Michael ^a   Pipik, Brenda ^a   Cameron, Mark ^b   Davies, Antony J ^b   Houghton, Peter G ^b   Ashwood, Michael S ^b   Cottrell, Ian F ^b   Reamer, Robert A ^a   Kennedy, Derek J ^b   Dolling, Ulf H ^a   Reider, Paul J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Merck Sharp & Dohme Limited   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ISOLATION; ONE-POT SYNTHESIS;

AMINO ACIDS; BIOSYNTHESIS; REACTION KINETICS;

ANTIBIOTICS;

2 AMINOCARBONYLPYRROLIDIN 4 YL THIOERTAPENEM; 3[[(4 MERCAPTO 2 PYRROLIDINYL)CARBONYL]AMINO]BENZOIC ACID; ANTIBIOTIC AGENT; BENZOIC ACID DERIVATIVE; ERTAPENEM; N (O,O DIISOPROPYLPHOSPHORYL) 4 HYDROXYPROLINE; PROLINE DERIVATIVE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BETA LACTAM; CARBAPENEM DERIVATIVE; LACTAM; PYRROLIDINE DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; DRUG ISOLATION; DRUG MANUFACTURE; DRUG SYNTHESIS; PROCESS DESIGN; PRODUCT RECOVERY; REACTION ANALYSIS; REACTION OPTIMIZATION; CHEMISTRY; COMBINATORIAL CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEREOISOMERISM; SYNTHESIS;

ANTI-INFECTIVE AGENTS; ANTIBIOTICS, LACTAM; CARBAPENEMS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; MOLECULAR STRUCTURE; PYRROLIDINES; STEREOISOMERISM; ANTI-BACTERIAL AGENTS; BETA-LACTAMS; LACTAMS;

EID: 0037067333     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo011170c     Document Type: Article

References (37)