Synthesis and modification of a novel 1β-methyl carbapenem antibiotic, S-4661

Journal of Antibiotics

Volumn 49, Issue 5, 1996, Pages 478-484

  Iso, Yasuyoshi ^a   Irie, Tadashi ^a   Iwaki, Tsutomu ^a   Kii, Makoto ^a   Sendo, Yuji ^a   Motokawa, Kiyoshi ^a   Nishitani, Yasuhiro ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM DERIVATIVE; DORIPENEM;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CONTROLLED STUDY; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; CARBAPENEMS; MICROBIAL SENSITIVITY TESTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030012502     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.49.478     Document Type: Article

References (8)

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2. TEBBEN, P.; M. REGGELIN & D. HOPPE: Enantiomerically α′, β′-difunctionalized α, β-enones by highly diastereo-selective nucleophilic alkenoylation of chiral aldehydes. Tetrahedron Letters 30: 2919-2922, 1989
3. KUME, M.; T. KUBOTA & Y. ISO: Novel and efficient synthesis of 1β-methylcarbapenems utilizing cyclization of hypervalent iodonium ylides. Tetrahedron Letters 36: 8043-8046, 1995
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6. KROPP, H.; J. G. SUNDELOF, J. S. KAHAN, F. M. KAHAN & J. BIRNBAUM: MK0787 (N-Formimidoylthienamycin): Evaluation of in vitro and in vivo activities. Antimicrob. Agents Chemother 17: 993-1000, 1980
7. KAHAN, F. M.; H. KROPP, J. G. SUNDELOF & J. BIRNBAUM: Thienamycin: development of imipenem-cilastatin. J. Antimicrob. Chemother. 12 (Suppl. D): 1-35, 1983
8. SUNAGAWA, M.; H. MATSUMURA, T. INOUE, M. FUKASAWA & M. KATO: A novel carbapenem antibiotic, SM-7338 Structure-activity relationships. J. Antibiotics 43: 519-532, 1990