Human galanin expresses amphipathic properties that modulate its vasoreactivity in vivo

Peptides

Volumn 24, Issue 9, 2003, Pages 1373-1380

  Dagar, Sumeet ^a,d   Önyüksel, Hayat ^a,b   Akhter, Syed ^a,c   Krishnadas, Aparna ^a   Rubinstein, Israel ^a,c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b University of Illinois at Chicago   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d Product Development   (United States)

Author keywords

CMC; Hamster cheek pouch; Microcirculation; Neuropeptide; Receptor antagonist; Sterically stabilized phospholipid micelles; Vasodilation

Indexed keywords

BIOMIMETIC MATERIAL; GALANIN; GALANIN RECEPTOR; GALANIN RECEPTOR ANTAGONIST; PEPTIDE; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HAMSTER; HUMAN; IN VIVO STUDY; MALE; MICROCIRCULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; VASOCONSTRICTION;

CRICETINAE;

EID: 0346099147     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2003.08.007     Document Type: Article

References (42)

1. Bartfai T., Bedecs K., Land T., Langel U., Bertorelli R., Girotti P.et al. M-15: high-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus, and spinal cord. Proc. Natl. Acad. Sci. USA. 88:1991;10961-10965.
2. Branchek T.A., Smith K.E., Gerald C., Walker M.W. Galanin receptor subtypes. Trends Pharmacol. Sci. 21:2000;109-117.
3. Ceresini G., Sgoifo A., Freddi M., Musso E., Parmigiani S., Del Rio G.et al. Effects of galanin and the galanin receptor antagonist galantide on plasma catecholamine levels during a psychosocial stress stimulus in rats. Neuroendocrinology. 67:1998;67-72.
4. Crawley J.N. Minireview. Galanin-acetylcholine interactions: relevance to memory and Alzheimer's disease. Life Sci. 58:1996;2185-2199.
5. Crawley J.N. The role of galanin in feeding behavior. Neuropeptides. 33:1999;369-375.
6. Dey R.D., Zhu W. Origin of galanin in nerves of cat airways and colocalization with vasoactive intestinal peptide. Cell Tissue Res. 273:1993;193-200.
7. Ekblad E., Hakanson R., Sundler F., Wahlestedt C. Galanin: neuromodulatory and direct contractile effects on smooth muscle preparations. Br. J. Pharmacol. 86:1985;241-246.
8. El-Salhy M. Neuroendocrine peptides in stomach and colon of an animal model for human diabetes type I. J. Diabetes Complicat. 13:1999;170-173.
9. Gandhi S., Rubinstein I., Tsueshita T., Önyüksel H. Secretin self-assemblies and interacts spontaneously with phospholipids in vitro. Peptides. 23:2002;201-204.
10. Gandhi S., Tsueshita T., Önyüksel H., Chandiwala R., Rubinstein I. Interactions of human secretin with sterically stabilized phospholipid micelles amplify peptide-induced vasodilation in vivo. Peptides. 23:2002;1433-1439.
11. Gao X.-P., Noda Y., Rubinstein I., Paul S. Vasoactive intestinal peptide encapsulated in liposomes: effects on systemic arterial blood pressure. Life Sci. 54:1994;L247-L252.
12. Gao X.-P., Suzuki H., Olopade C.O., Rubinstein I. Short-term exposure to lipopolysaccharide is associated with microvascular contractile dysfunction in vivo. Life Sci. 56:1995;1243-1249.
13. Gololobov G., Noda Y., Sherman S., Rubinstein I., Baranowska-Kortylewicz J., Paul S. Stabilization of vasoactive intestinal peptide by lipids. J. Pharmacol. Exp. Ther. 285:1998;753-758.
14. Harling H., Holst J.J. Circulating galanin: origin, metabolism, and pharmacokinetics in anesthetized pigs. Am. J. Physiol. 262:1992;E52-E57.
15. Ignarro L.J., Byrns R.E., Buga G.M., Wood K.S. Mechanisms of endothelium-dependent vascular smooth muscle relaxation elicited by bradykinin and VIP. Am. J. Physiol. 253:1987;H1074-H1082.
16. Ikezaki H., Paul S., Alkan-Onyuksel H., Patel M., Gao X.-P., Rubinstein I. Vasodilation elicited by liposomal VIP is unimpeded by anti-VIP antibody in hamster cheek pouch. Am. J. Physiol. 275:1998;R56-R62.
17. Jureus A., Lindgren M., Langel U., Bartfai T. Purification of a galanin degrading 70. kDa metallo-peptidase from bovine spinal cord Neuropeptides. 32:1998;453-460.
18. Kagstrom J., Olsson C., Axelsson M., Franklin C.E. Peptidergic control of gastrointestinal blood flow in the estuarine crocodile, Crocodylus porosus. Am. J. Physiol. 274:1998;R1740-R1750.
19. Kakuyama H., Kuwahara A., Mochizuki T., Hoshino M., Yanaihara N. Role of N-terminal active sites of galanin in neurally evoked circular muscle contractions in the guinea-pig ileum. Eur. J. Pharmacol. 329:1997;85-91.
20. Kask K., Berthold M., Bartfai T. Galanin receptors: involvement in feeding, pain, depression and Alzheimer's disease. Life Sci. 60:1997;1523-1533.
21. Kask K., Langel U., Bartfai T. Galanin - a neuropeptide with inhibitory actions. Cell. Mol. Neurobiol. 15:1995;653-673.
22. Lindskog S., Ahren B., Land T., Langel U., Bartfai T. The novel high-affinity antagonist, galantide, blocks the galanin- mediated inhibition of glucose-induced insulin secretion. Eur. J. Pharmacol. 210:1992;183-188.
23. Luc G., Majd Z., Poulain P., Elkhalil L., Fruchart J.C. Interstitial fluid apolipoprotein A-II: an association with the occurrence of myocardial infarction. Atherosclerosis. 127:1996;131-137.
24. Lukyanov A.N., Gao Z., Mazzola L., Torchilin V.P. Polyethylene glycol-diacyllipid micelles demonstrate increased accumulation in subcutaneous tumors in mice. Pharm. Res. 19:2002;1424-1429.
25. Odorizzi M., Fernette B., Angel E., Burlet C., Tankosic P., Burlet A. Galanin receptor antagonists decrease fat preference in Brattleboro rat. Neuropharmacology. 42:2002;134-141.
26. Ohman A., Lycksell P.O., Jureus A., Langel U., Bartfai T., Graslund A. NMR study of the conformation and localization of porcine galanin in SDS micelles. Comparison with an inactive analog and a galanin receptor antagonist. Biochemistry. 37:1998;9169-9178.
27. Önyüksel H., Bodalia B., Sethi V., Dagar S., Rubinstein I. Surface-active properties of vasoactive intestinal peptide. Peptides. 21:2000;419-423.
28. Önyüksel H., Ikezaki H., Patel M., Gao X.-P., Rubinstein I. A novel formulation of VIP in sterically stabilized micelles amplifies vasodilation in vivo. Pharm Res. 16:1999;155-160.
29. Preston E., McManus C.D., Jonsson A.C., Courtice G.P. Vasoconstrictor effects of galanin and distribution of galanin containing fibers in three species of elasmobranch fish. Regul. Pept. 58:1995;123-134.
30. Rubinstein I., Mayhan W.G. L-arginine dilates cheek pouch arterioles in hamsters with hereditary cardiomyopathy but not in controls. J. Lab. Clin. Med. 125:1995;313-318.
31. Rubinstein I., Patel M., Ikezaki H., Dagar S., Önyüksel H. Conformation and vasoreactivity of VIP in phospholipids: effects of calmodulin. Peptides. 20:1999;1497-1501.
32. Santha P., Pierau F.K., Jancso G. Evidence for an inhibition by endogenous galanin of neurogenic cutaneous vasodilatation in the pigeon. Neurosci. Lett. 243:1998;101-104.
33. Santha P., Pierau F.K., Jancso G. Inhibitory modulation of cutaneous vascular responses by endogenous galanin in the pigeon. Neurosci. Lett. 273:1999;64-66.
34. Séjourné F., Rubinstein I., Suzuki H., Alkan-Onyuksel H. Development of a novel bioactive formulation of vasoactive intestinal peptide in sterically stabilized liposomes. Pharm. Res. 14:1997;362-365.
35. Séjourné F., Suzuki H., Alkan-Onyuksel H., Gao X.-P., Ikezaki H., Rubinstein I. Mechanisms of vasodilation elicited by VIP in sterically stabilized liposomes in vivo. Am. J. Physiol. 273:1997;R287-R292.
36. Sethi V, Rubinstein I, Onyuksel H. Vasoactive intestinal peptide (VIP) loaded sterically stabilized micelles (SSM) for improved therapy of collagen induced arthritis (CIA) in mice (Abstract). Pharm Sci 2002;4 (Suppl):T2036.
37. Tsueshita T., Gandhi S., Önyüksel H., Rubinstein I. Phospholipids modulate the biophysical properties and vasoactivity of PACAP-(1-38). J. Appl. Physiol. 93:2002;1377-1383.
38. Ulman L.G., Moriarty M., Potter E.K., McCloskey D.I. Galanin antagonist effects on cardiac vagal inhibitory actions of sympathetic stimulation in anaesthetized cats and dogs. J. Physiol. 464:1993;491-499.
39. Vessby B., Gustafson S., Chapman M.J., Hellsing K., Lithell H. Lipoprotein composition of human suction-blister interstitial fluid. J. Lipid Res. 28:1987;629-641.
40. Vittoria A., Costagliola A., Carrese E., Mayer B., Cecio A. Nitric oxide-containing neurons in the bovine gut, with special reference to their relationship with VIP and galanin. Arch. Histol. Cytol. 63:2000;357-368.
41. Wang Y.F., Mao Y.K., Fox-Threlkeld J.E., McDonald T.J., Daniel E.E. Colocalization of inhibitory mediators, NO, VIP and galanin, in canine enteric nerves. Peptides. 19:1998;99-112.
42. Xia W.J., Önyüksel H. Mechanistic studies on surfactant-induced membrane permeability enhancement. Pharm. Res. 17:2000;612-618.