Inhibition of human napsin A

Protein and Peptide Letters

Volumn 10, Issue 1, 2003, Pages 35-42

  Cronshaw, Rebecca F ^a   Schauer Vukasinovic, Vesna ^b,d   Powell, David J ^c   Giller, Thomas ^b,e   Bur, Daniel ^b,f   Kay, John ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c GLAXOSMITHKLINE   (United Kingdom)

^d Biovertis AG   (Germany)

^e Axovan Ltd   (Switzerland)

^f ACTELION PHARMACEUTICALS LTD   (Switzerland)

Author keywords

Active site mapping; Importance of S1 S3.; New human aspartic proteinase; Selectivity of inhibition

Indexed keywords

AMINO ACID; ASPARTIC PROTEINASE; ENZYME INHIBITOR; NAPSA PROTEIN, HUMAN; PEPSTATIN; PEPTIDE; RECOMBINANT PROTEIN; STATINE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; ASCARIS LUMBRICOIDES; BINDING SITE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; KINETICS;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; ASCARIS LUMBRICOIDES; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CELLS, CULTURED; ENZYME INHIBITORS; HUMANS; KINETICS; MODELS, MOLECULAR; PEPSTATINS; PEPTIDES; RECOMBINANT PROTEINS;

ANIMALIA; ASCARIS; ASCARIS LUMBRICOIDES; SOLANUM TUBEROSUM;

EID: 0346033369     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929866033408237     Document Type: Article

References (18)

1. Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (eds) (1998) In, Handbook of Proteolytic Enzymes pp. 802-805 Academic Press, London.
2. Grüninger-Leitch, F., Schlatter, D., Küng, E., Elböck, P. and Döbeli H. (2002) J. Biol. Chem. 277, 4687-4693.
3. Hussain, I., Powell, D.J., Howlett, D.R., Tew, D.G., Meek, T.D., Chapman, C., Gloger, I.S., Murphy, K.E., Southan. C.D., Ryan, D.M., Smith, T.S., Simmons, D.L., Walsh, F.S., Dingwall, C. and Christie, G. (1999) Mol. Cell. Neurosci. 14, 419-427.
4. Tatnell, P.J., Powell, D.J., Hill, J., Smith. T.S., Tew, D.G. and Kay, J. (1998) FEBS Lett. 441, 43-48.
5. Tatnell, P.J., Cook, M., Peters, C. and Kay, J. (2000) Eur. J. Biochem. 267, 6921-6930.
6. Cook, M., Bühling, F., Ansorge, S., Tatnell, P.J. and Kay, J. (2002) Biochim. Biophys. Acta 1577. 10-16.
7. Chuman, Y., Bergman, A-C., Ueno, T., Saito, S., Sakaguchi, K., Alaiya, A.A., Franzen, B., Bergman, T., Arnott, D., Auer, G., Appella, E., Jörnvall, H. and Linder, S. (1999) FEBS Lett. 462, 129-134.
8. Schauer-Vukasinovic, V., Bur, D., Kling, D., Grüninger, F. and Giller, T. (1999) FEBS Lett. 462, 135-139.
9. Schauer-Vukasinovic, V., Bur, D., Kitas, E., Schlatter, D., Rosse, G., Lahm, H-W. and Giller, T. (2000) Eur. J. Biochem. 267, 2573-2580.
10. Jupp, R.A., Dunn, B.M., Jacobs, J.W., Vlasuk, G., Arcuri, K.E., Veber, D.F., Perlow, D.S., Payne, L.S., Boger, J., de Laszlo, S., Chakravarty, P.K. tenBroeke, J., Hangauer, D.G., Ondeyka, D., Greenlee, W.J. and Kay, J. (1990) Biochem. J. 265, 871-878.
11. Baldwin, E.T., Bhat, T.N., Gulnik, S., Hosur, M.V., Sowder, R.C., Cachau, R.E., Collins, J., Silva, A.E. and Erickson, J.W. (1993) Proc. Natl Acad. Sci. USA, 90, 6796-6801.
12. Ng, K.K.S., Petersen, J.F.W., Cherney, M.M., Garen, C., Zalatoris, J.J., Rao-Naik, C., Dunn, B.M., Martzen, M.R., Peanasky, R.J. and James, M.N.G. (2000) Nature Struct. Biol. 7, 653-657.
13. Christeller, J.T., Farley, P.C., Ramsey, R.J., Sullivan, P.A. and Laing, W.A. (1998) Eur. J. Biochem. 254, 160-167.
14. Cater, S.A., Lees, W.E., Hill, J., Brzin, J., Kay, J. and Phylip L.H. (2002) Biochim. Biophys. Acta 1596, 76-82.
15. Phylip, L.H., Lees, W.E., Brownsey, B.G., Bur, D., Dunn, B.M., Winther, J.R., Gustchina, A., Li, M., Copeland, T., Wlodawer, A. and Kay, J. (2001) J. Biol. Chem. 276, 2023-2030.
16. Valler, M.J., Kay, J. Aoyagi, T. and Dunn, B.M. (1985) J. Enzyme Inhib. 1, 77-82.
17. Dunn, B.M. and Hung, S. (2000) Biochim. Biophys. Acta 1477, 231-240.
18. Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A. and Cooper, J.B. (2000) J. Mol. Biol. 303, 745-760.