Leucascandrolide A: A Second Generation Formal Synthesis

Organic Letters

Volumn 5, Issue 26, 2003, Pages 5035-5038

  Williams, David R ^a   Patnaik, Samarjit ^a   Plummer, Scott V ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTONE DERIVATIVE; LEUCASCANDROLIDE A; UNCLASSIFIED DRUG;

ALLYLATION; ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; ENANTIOMER; REACTION ANALYSIS; REDUCTION;

ALLYL COMPOUNDS; ANIMALS; INDICATORS AND REAGENTS; PORIFERA; SESQUITERPENES; STEREOISOMERISM;

EID: 0346025396     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol036071v     Document Type: Article

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43. Yamaguchi conditions also led to small amounts (5-15%) of the [3.3.1]-bicyclic lactone i, which can be recycled to the seco-acid 23 via KOH, aqueous methanol. (Equation Presented)
44. 5 tetrahydropyranone; for direct comparison with a sample independently prepared from our first generation strategy, see ref 3b.