Increased homocysteine levels associated with sex and stress in the learned helplessness model of depression

Pharmacology Biochemistry and Behavior

Volumn 77, Issue 1, 2004, Pages 155-161

  Setnik, Beatrice ^a,b   De Souza, Fernanda Gonçalves ^c   D'Almeida, Vania ^c   Nobrega, José N ^a,b  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Estrous cycle; Major depression; Sex; Stress

Indexed keywords

HOMOCYSTEINE;

AMINO ACID BLOOD LEVEL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIESTRUS; DISEASE ASSOCIATION; ESTRUS; ESTRUS CYCLE; FEMALE; FUNCTION TEST; LEARNED HELPLESSNESS; MAJOR DEPRESSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; RISK FACTOR; SEX DIFFERENCE; SEXUAL BEHAVIOR; STATISTICAL SIGNIFICANCE; STRESS; VULNERABLE POPULATION;

EID: 0346023967     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2003.10.006     Document Type: Article

References (45)

1. Alonso S.J., Castellano M.A., Afonso D., Rodriguez M. Sex differences in behavioral despair: relationships between behavioral despair and open field activity. Physiol. Behav. 49:1991;69-72.
2. Andersson A., Brattstrom L., Israelsson B., Isaksson A., Hamfelt A., Hultberg B. Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status. Eur. J. Clin. Investig. 22:1992;79-87.
3. Angold A., Worthman C.W. Puberty onset of gender differences in rates of depression: a developmental, epidemiological and neuroendocrine perspective. J. Affect. Disord. 29:1993;145-158.
4. Bell K.M., Plon L., Bunney W.E. Jr., Potkins S.G. S-adenosylmethionine treatment of depression: a controlled clinical trial. Am. J. Psychiatry. 145:1988;1110-1114.
5. Bortolotto L.A., Safar M.E., Billaud E., Lacroix C., Asmar R., London G.M.et al. Plasma homocysteine, aortic stiffness, and renal function in hypertensive patients. Hypertension. 34:1999;837-842.
6. Bottiglieri T., Laundy M., Crellin R., Toone B.K., Carney M.W., Reynolds E.H. Homocysteine, folate, methylation and monoamine metabolism in depression. J. Neurol. Neurosurg. Psychiatry. 69:2000;121-130.
7. Crellin R., Bottiglieri T., Reynolds E.H. Folates and psychiatric disorders. Clinical potential. Drugs. 45:1993;623-636.
8. De Cree C., Malinow M.R., van Kranenburg G.P., Geurten P.G., Longford N.T., Keizer H.A. Influence of exercise and menstrual cycle phase on plasma homocysteine levels in young women - a prospective study. Scand. J. Med. Sci. Sports. 1999;272-278.
9. Delle Chiaie R., Pancheri P., Scapicchio P. Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies. Am. J. Clin. Nutr. 2002;1172S-1176S.
10. Dierkes J., Jeckel A., Ambrosch A., Westphal S., Luley C., Boeing H. Factors explaining the difference of total homocysteine between men and women in the European Investigation Into Cancer and Nutrition Potsdam Study. Metabolism. 50:2001;640-645.
11. Dimitrova K.R., DeGroot K.W., Pacquing A.M., Suyderhoud J.P., Pirovic E.A., Munro T.J.et al. Estradiol prevents homocysteine-induced endothelial injury in male rats. Cardiovasc. Res. 53:2002;589-596.
12. Drugan R.C., Skolnick P., Paul S.M., Crawley J.N. A pretest procedure reliably predicts performance in two animal modes of inescapable stress. Pharmacol. Biochem. Behav. 33:1982;6499-6654.
13. Duan W., Ladenheim B., Cutler R.G., Kruman I.I., Cadet J.L., Mattson M.P. Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. J. Neurochem. 80:2002;101-110.
14. Edwards E., Johnson J., Anderson D., Turano P., Henn F.A. Neurochemical and behavioral consequences of mild, uncontrollable shock: effects of PCPA. Pharmacol. Biochem. Behav. 25:1986;415-421.
15. Edwards E., King J.A., Fray J. Hypertension and insulin resistant models have divergent propensities to learned helpless behavior in rodents. Am. J. Hypertens. 13:2000;659-665.
16. El-Swefy S.E., Ali S.I., Asker M.E., Mohamed H.E. Hyperhomocysteinaemia and cardiovascular risk in female ovariectomized rats: role of folic acid and hormone replacement therapy. J. Pharm. Pharmacol. 54:2002;391-397.
17. Endicott J. The menstrual cycle and mood disorders. J. Affect. Disord. 29:1993;193-200.
18. Farag N.H., Barshop B.A., Mills P.J. Effects of estrogen and psychological stress on plasma homocysteine levels. Fertil. Steril. 79:2003;256-260.
19. Fava M., Borus J.S., Alpert J.E., Nierenberg A.A., Rosenbaum J.F., Bottiglieri T. Folate, B12 and homocysteine in major depressive disorder. Am. J. Psychiatry. 154:1997;426-428.
20. Godfrey P.S., Toone B.K., Carney M.W., Flynn T.G., Bottiglieri T., Laundy M.et al. Enhancement of recovery from psychiatric illness by methylfolate. Lancet. 336:1990;392-395.
21. Hale W.D., Cochran C.D. Sex differences in patterns of self-reported psychopathology in the married elderly. J. Clin. Psychol. 39:1983;647-650.
22. Jenkins J.A., Williams P., Kramer G.L., Davis L.L., Petty F. The influence of gender and the estrous cycle on learned helplessness in the rat. Biol. Psychol. 58:2001;147-158.
23. Kagan B.L., Sultzer D.L., Rosenlicht N., Gerner R.H. Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am. J. Psychiatry. 147:1990;591-595.
24. Kessler R.C., Mcgonagle K.A., Swartz M., Blazer D.G., Nelson C.B. Sex and depression in the National Comorbidity Survey I: lifetime prevalence, chronicity and recurrence. J. Affect. Disord. 29:1993;85-96.
25. Kruman I.I., Kumaravel T.S., Lohani A., Pedersen W.A., Cutler R.G., Kruman Y.et al. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J. Neurosci. 22:2002;1752-1762.
26. Maeda K., Okhura S., Tsukamura H. Physiology of reproduction: estrous cycle, identification of the estrous cycle. Krinkle G.J., Bullock G., Bunton T.E. The handbook of experimental animals: the laboratory rat. 2002;152-155 Academic Press, San Diego.
27. Maravan M.L., Chavez-Chavez L.C., Santana S. Clomipramine modifies fluctuations of forced swimming immobility in different phases of the rat cycle. Arch. Med. Res. 27:1996;83-87.
28. Mendis S., Athauda S.B., Naser M., Takahashi K. Association between hyperhomocysteinemia and hypertension in Sri Lankans. J. Int. Med. Res. 27:1999;38-44.
29. Merki-Feld G.S., Imthurn B., Keller P.J. The effect of the menstrual cycle and of ethinylestradiol on nitric oxide, endothelin-1 and homocysteine plasma levels. Horm. Metab. Res. 32:2000;288-293.
30. Miller K.J., Conney J.C., Rasgon N.L., Fairbanks L.A., Small G.W. Mood symptoms and cognitive performance in women estrogen users and nonusers and men. J. Am. Geriatr. Soc. 50:2002;1826-1830.
31. Morris M.S., Jacques P.F., Selhub J.K., Rosenberg I.H. Total homocysteine and estrogen status indicators in the Third National Health and Nutrition Examination Survey. Am. J. Epidemiol. 152:2000;140-148.
32. Perry I.J. Homocysteine, hypertension and stroke. J. Cardiovasc. Risk. 6:1999;235-240.
33. Petty F., Kramer G., Wilson L. Prevention of learned helplessness: in vivo correlation with cortical serotonin. Pharmacol. Biochem. Behav. 43:1992;361-367.
34. Pfeiffer C.M., Huff D.L., Gunter E.W. Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting. Clin. Chem. 45:1999;290-292.
35. Rasgon N.L., Altshuler L.L., Fairbanks L.A., Dunkin J.J., Davtyan C., Elman S.et al. Estrogen replacement therapy in the treatment of major depressive disorder in perimenopausal women. J. Clin. Psychiatry. 63(Suppl. 7):2002;45-48.
36. Stabler S.P., Marcell P.D., Podell E.R., Allen R.H., Savage D.G., Lindenbaum J. Elevation of total homocysteine in serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. J. Clin. Invest. 81:1988;466-474.
37. Steenbergen H.L., Heinsbroek R.P., van Haaren F., van de Poll N.E. Sex-dependent effects of inescapable chock administration on behavior and subsequent escape performance in rats. Physiol. Behav. 45:1989;781-787.
38. Stoney C.M. Plasma homocysteine levels increase in women during psychological stress. Life Sci. 64:1999;2359-2365.
39. Verhoef P., Meleady R., Daly L.E., Graham I.M., Robinson K. Homocysteine, vitamin status and risk of vascular disease; effects of gender and menopausal status. Eur. Heart J. 20:1999;1234-1244.
40. Weissman M.M., Bland R., Joyce P.R., Newman S., Wells J.E., Wittchen H.U. Sex differences in rates of depression: cross-national perspectives. J. Affect. Disord. 29:1993;77-84.
41. Willner P. Validation criteria for animal models of human mental disorders: learned helplessness as a paradigm case. Prog. Neuropsychopharmacol. Biol. Psychiatry. 10:1986;677-690.
42. Willner P. Animal models as simulations of depression. Trends Pharmacol. Sci. 12:1991;131-136.
43. Yildirir A., Aybar F., Tokgozoglu L., Yarali H., Kabakci G., Bukulmez O.et al. Effects of hormone replacement therapy on plasma homocysteine and C-reactive protein levels. Gynecol. Obstet. Invest. 53:2002;54-58.
44. Yonkers K.A., White K. Premenstrual exacerbation of depression: one process or two? J. Clin. Psychiatry. 53:1992;289-292.
45. Zmuda J.M., Bausserman L.L., Maceroni D., Thompson P.D. The effect of supraphysiologic doses of testosterone on fasting total homocysteine levels in normal men. Atherosclerosis. 130:1997;199-202.