Essential Role of Junctional Adhesion Molecule-1 in Basic Fibroblast Growth Factor-Induced Endothelial Cell Migration

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 23, Issue 12, 2003, Pages 2165-2171

  Naik, Meghna U ^a   Vuppalanchi, Deepika ^a   Naik, Ulhas P ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

Basic fibroblast growth factor; Endothelial cell migration; Extracellular signal related kinase; Junctional adhesion molecule 1; Small interfering RNA

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CELL ADHESION MOLECULE; FIBRONECTIN; JUNCTIONAL ADHESION MOLECULE A; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VITRONECTIN;

ANGIOGENESIS; ARTICLE; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CELL SPREADING; ENDOTHELIUM CELL; ENZYME ACTIVATION; GAP JUNCTION; HUMAN; HUMAN CELL; HUMAN UMBILICAL CORD ENDOTHELIUM CELL; KNOCKOUT GENE; NEOVASCULARIZATION (PATHOLOGY); PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

CELL ADHESION; CELL ADHESION MOLECULES; CELL MOVEMENT; CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; FIBROBLAST GROWTH FACTOR 2; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, CELL SURFACE; RNA, SMALL INTERFERING; TIGHT JUNCTIONS; UMBILICAL VEINS; VITRONECTIN;

EID: 0345991242     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000093982.84451.87     Document Type: Article

References (25)

1. Pintucci G, Moscatelli D, Saponara F, Biernacki PR, Baumann FG, Bizekis C, Galloway AC, Basilico C, Mignatti P. Lack of ERK activation and cell migration in FGF-2-deficient endothelial cells. FASEB J. 2002; 16:598-600.
2. Brooks PC, Clark RA, Cheresh DA. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science. 1994;264:569-571.
3. Eliceiri BP, Klemke R, Stromblad S, Cheresh DA. Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J Cell Biol. 1998;140:1255-1263.
4. Roberts MS, Woods AJ, Shaw PE, Norman JC. ERKI associates with alpha(v)beta 3 integrin and regulates cell spreading on vitronectin. J Biol Chem. 2003;278:1975-1985.
5. Voura EB, Ramjeesingh RA, Montgomery AM, Siu CH. Involvement of integrin alpha(v)beta(3) and cell adhesion molecule L1 in transendothelial migration of melanoma cells. Mol Biol Cell. 2001;12:2699-2710.
6. Chellaiah MA, Hruska KA. The integrin {alpha}(v){beta}(3) and CD44 regulate the actions of osteopontin on osteoclast motility. Calcif Tissue Int. 2003;72:197-205.
7. Bazzoni G, Martinez-Estrada OM, Mueller F, Nelboeck P, Schmid G, Bartfai T, Dejana E, Brockhaus M. Homophilic interaction of junctional adhesion molecule. J Biol Chem. 2000;275:30970-30976.
8. Kostrewa D, Brockhaus M, D'Arcy A, Dale GE, Nelboeck P, Schmid G, Mueller F, Bazzoni G, Dejana E, Bartfai T, Winkler FK, Hennig M. X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motif. EMBO J. 2001;20:4391-4398.
9. Naik UP, Naik MU, Eckfeld K, Martin-DeLeon P, Spychala J. Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody. J Cell Sci. 2001;114:539-547.
10. Liu Y, Nusrat A, Schnell FJ, Reaves TA, Walsh S, Pochet M, Parkos CA. Human junction adhesion molecule regulates tight junction resealing in epithelia. J Cell Sci. 2000;113:2363-2374.
11. Ozaki H, Ishii K, Horiuchi H, Arai H, Kawamoto T, Okawa K, Iwamatsu A, Kita T. Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J Immunol. 1999;163:553-557.
12. Ostermann G, Weber KS, Zernecke A, Schroder A, Weber C. JAM-1 is a ligand of the beta2 integrin LFA-1 involved in transendothelial migration of leukocytes. Nat Immunol. 2002;3:151-158.
13. Naik MU, Parkos CA, Mousa SA, Naik UP. Signaling through JAM-1 and alpha v beta 3 is required for the angiogenic action of bFGF: dissociation of the JAM-1 and alpha v beta 3 complex. Blood. 2003;102: 2108-2114.
14. Liu X, Erikson RL. Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of P1k1 by siRNA. Proc Natl Acad Sci U S A. 2002;99:8672-8676.
15. Angers-Loustau A, Cote JF, Tremblay ML. Roles of protein tyrosine phosphatases in cell migration and adhesion. Biochem Cell Biol. 1999; 77:493-505.
16. Keely PJ, Fong AM, Zutter MM, Santoro SA. Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense alpha 2 integrin mRNA in mammary cells. J Cell Sci. 1995; 108:595-607.
17. Aplin AE, Short SM, Juliano RL. Anchorage-dependent regulation of the mitogen-activated protein kinase cascade by growth factors is supported by a variety of integrin alpha chains. J Biol Chem. 1999;274: 31223-31228.
18. Naik UP, Patel PM, Parise LV. Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. J Biol Chem. 1997;272:4651-4654.
19. Bazzoni G, Martinez-Estrada OM, Orsenigo F, Cordenonsi M, Citi S, Dejana E. Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin. J Biol Chem. 2000; 275:20520-20526.
20. Ebnet K, Schulz CU, Meyer Zu Brickwedde MK, Pendl GG, Vestweber D. Junctional adhesion molecule (JAM) interacts with the PDZ domain containing proteins AF-6 and ZO-1. J Biol Chem. 2000;275:27979-27988.
21. Friedlander M, Brooks PC, Shaffer RW, Kincaid CM, Varner JA, Cheresh DA. Definition of two angiogenic pathways by distinct alpha v integrins. Science. 1995;270:1500-1502.
22. Dedhar S. Integrins and signal transduction. Curr Opin Hematol. 1999; 6:37-43.
23. Elbashir SM, Harborth J, Weber K, Tuschl T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods. 2002;26:199-213.
24. Itoh M, Sasaki H, Furuse M, Ozaki H, Kita T, Tsukita S. Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions. J Cell Biol. 2001;154:491-498.
25. Tanaka K, Abe M, Sato Y. Roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the signal transduction of basic fibroblast growth factor in endothelial cells during angiogenesis. Jpn J Cancer Res. 1999;90:647-654.