Underlying Mechanisms of Impaired Visceral Pain Perception in Older People

Journal of the American Geriatrics Society

Volumn 52, Issue 1, 2004, Pages 132-136

  Moore, Alan R ^a   Clinch, David ^a  

^a UNIVERSITY HOSPITAL LIMERICK   (Ireland)

Author keywords

Aging; Nociception; Visceral pain

Indexed keywords

AGE; AGED; AGING; ANALGESIA (SENSORY DYSFUNCTION); ARTICLE; HEART INFARCTION; HUMAN; HYPOALGESIA; NEUROIMAGING; NOCICEPTION; NOCICEPTIVE STIMULATION; PATHOPHYSIOLOGY; PEPTIC ULCER; PNEUMOTHORAX; SENSORY NERVE CONDUCTION; SIGNAL TRANSDUCTION; SOMATOSENSORY SYSTEM; VISCERAL PAIN;

AGED; HUMANS; NOCICEPTORS; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PERCEPTION; VISCERA;

EID: 0345868387     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2004.52023.x     Document Type: Article

References (34)

1. Rich MW. Management of the older patient with acute myocardial infarction: Difference in clinical presentations between older and younger patients. J Am Geriatr Soc 1998;46:1302-1307.
2. Liston R, McLoughlin R, Clinch D. Acute pneumothorax. A comparison of elderly with younger patients. Age Ageing 1994;23:393-395.
3. Hilton D, Iman N, Burke G et al. Absence of abdominal pain in older persons with endoscopic ulcers: A prospective study. Am J Gastroenterol 2001;96: 380-384.
4. Lasch H, Castell DO, Castell JA. Evidence for diminished visceral pain with aging: Studies using graded intraesophageal balloon distension. Am J Physiol 1997;272(1 Part 1):G1-G3.
5. Lagier E, Delvaux M, Vellas B et al. Influence of age on rectal tone and sensitivity to distension in healthy subjects. Neurogastroenterol Motil 1999;11:101-107.
6. Ferrell BA. Overview of aging and pain. In: Ferrell BR, Ferrell BA, eds. Pain in the Elderly. Seattle, WA: IASP Press, 1996, pp 1-10.
7. Vreeburg EM, Snel P, De Bruijne JW et al. Acute upper gastrointestinal bleeding in the Amsterdam area. Incidence, diagnosis and clinical outcome. Am J Gastroenterol 1997;92:236-243.
8. Rich MW. Therapy for acute myocardial infarction. Clin Geriatr Med 1996;12:141-168.
9. Harkins SW, Kwentus J, Price D. Pain and the Elderly. In: Benedetti C, Chapman CR, Moricca G, eds. Advances in Pain Research and Therapy (Vol. 7). New York: Raven Press, 1984, pp 103-121.
10. Gagliese L, Melzack R. Age differences in nociception and pain behaviours in the rat. Neurosci Biobehav Rev 2000;24:843-854.
11. Raja SN, Meyer RA, Ringkamp M et al. Peripheral neural mechanisms of nociception. In: Melzack R, Walls PD, eds. Textbook of Pain, 4th Ed. London: Churchill Livingstone, 1999, pp 11-45.
12. Besson JM. The neurobiology of pain. Lancet 1999;353:1610-1615.
13. Craig AD, Dostrovsky JO. Medulla to Thalamus. In: Melzack R, Walls PD, eds. Textbook of Pain, 4th Ed. London: Churchill Livingstone, 1999, pp 183-214.
14. Al-Chaer ED, Feng Y, Willis WD. Comparative study of viscerosomatic inputs into the postsynaptic dorsal column and spinothalamic tract neurons in the primate. J Neurophysiol 1999;82:1876-1882.
15. Willis WD, Al-Chaer ED, Quast MJ et al. A visceral pain pathway in the postsynaptic dorsal column of the spinal cord. Proc Nat Acad Sci USA 1999;96:7675-7679.
16. Crisp T, Smith D. A local serotonergic component involved in the spinal antinociceptive action of morphine. Neuropharmacol 1989;28:1047-1053.
17. Sollenbohmer C, Enck P, Haussinger D et al. Electrically evoked cerebral potentials during esophageal distension at perception and pain threshold. Am J Gastroenterol 1996;91:970-975.
18. Silverman DHS, Munakata JA, Ennes H et al. Regional cerebral activity in normal and pathological perception of pain. Gastroenterology 1997;112: 64-72.
19. Aziz Q, Andersson JLR, Valind S et al. Identification of human brain loci processing esophageal sensation using positron emission tomography. Gastroenterology 1997;113:50-59.
20. Gagliese L, Melzack R. Age differences in the response to the formalin test in rats. Neurobiol Aging 1999;20:699-707.
21. Chakour MC, Gibson SJ, Bradbeer M et al. The effect of age on A-Delta and C fiber thermal pain perception. Pain 1995;64:143-152.
22. Bachman DS, Katz HM. Physiological responses to intravenous serotonin in the awake squirrel monkey. Physiol Behav 1977;18:987-984.
23. Meller ST, Lewis ST, Brody MJ et al. Age, strain and anaesthetic differences in the nociceptive effects produced by intravenous serotonin in the rat. Brain Res 1982;587:88-94.
24. Goicachea C, Ormazabal MJ, Alfaro M et al. Age-related changes in nociception behavior and monoamine levels in rats. Gen Pharmacol 1997;28: 331-336.
25. Marazitti D, Falcone MF, Rotondo A et al. Age-related differences in human platelet serotonin uptake. Nauyn-Schmiedebergs Arch Pharmacol 1989;340: 593-594.
26. Yonezewa Y, Kondo H, Nomaguchi TA. Age-related changes in serotonin content and its release in rat platelets. Mech Ageing Dev 1989; 47:65-75.
27. Anbar M, Gratt BM. The role of nitric oxide in the physiopathology of pain. J Pain Symptom Manag 1997;14:225-254.
28. Nozaki-Taguchi N, Yamamoto T. Involvement of nitric oxide in peripheral anti-nociception mediated by kappa and delta opioid receptors. Anaesth Analg 1998;87:388-393.
29. Lyons D, Roy S, Patel M et al. Impaired nitric oxide-mediated vasodilatation and total body production in healthy old age. Clin Sci 1997;93: 519-525.
30. Rosen SD, Paulesu E, Nihoyannopoulos P et al. Silent ischemia as a central problem. Regional brain activation compared in silent and painful myocardial ischemia. Ann Intern Med 1996;124:939-948.
31. Gibson SJ, Helme RD. Cognitive factors and the experience of pain and suffering in older persons. Pain 2000;85:375-383.
32. Hamm RJ, Kinesly JS. Environmentally induced analgesia: An age-related decline in an endogenous opioid system. J Gerontol 1985;40: 268-274.
33. Hamm RJ, Kinsely JS, Watson A. Environmentally induced analgesia: Age-related differences in a hormonally mediated, non-opioid system. J Gerontol 1986;41:336-341.
34. Sollenbohmer C, Enck P, Haussinger D et al. Electrically evoked cerebral potentials during oesophageal distension at perception and pain threshold. Am J Gastroenterol 1996;91:970-975.