Age-related changes in nociception, behavior, and monoamine levels in rats

General Pharmacology

Volumn 28, Issue 2, 1997, Pages 331-336

  Goicoechea, C ^a   Ormazabal M J ^a   Alfaro, M J ^a   Martin M I ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

aged rats; behavior; monoamines; pain

Indexed keywords

BRAIN MONOAMINE; DOPAMINE; SEROTONIN;

AGE; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; EMOTION; EXPLORATORY BEHAVIOR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LOCOMOTION; MALE; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; TAIL FLICK TEST;

AGING; ANIMALS; BEHAVIOR, ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOPAMINE; MALE; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, WISTAR; SEROTONIN;

EID: 0343052915     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00222-4     Document Type: Article

References (37)

1. Akunne H. C. and Soliman K. F. (1994) Serotonin modulation of pain responsiveness in the aged rat. Pharmacol Biochem. Behav. 48, 411-416.
2. Albonetti M. E. and Farabollini F. (1992) Behavioral responses to single and repeated restraint in male and female rats. Behav. Proc. 28, 97-110.
3. Broekkamp C. L. E., Berendsen H. H. G., Jenk F. and Van Delft A. M L. (1989) Animal models for anxiety and response to serotonergic drugs. Psychopathology 22, 2-12.
4. Carrol M. N. and Lim R. K. S. (1960) Observations on the neuropharmacology of morphine and morphine-like analgesia. Arch. Int. Pharmacodyn. 125, 383-403.
5. Crisp T., Stafinsky J. L., Hoskins D. L., Perni V. C., Uram M. and Gordon T. L. (1994) Age-related changes in the spinal antinociceptive effects of DAGO, DPDPE and beta-endorphin in the rat. Brain Res. 643, 282-286.
6. Dean R. L. and Bartus R. T. (1988) Behavioral models of aging in nonhuman primates. In: Handbook of Psychopharmacology. Edited by Iversen L. L., Iversen S. D., and Snyder S. H., pp. 325-392. Plenum, New York.
7. Dorce V. A. and Palermo-Neto J. (1994) Behavioral and neurochemical changes induced by aging in dopaminergic systems of male and female rats. Physiol. Behav. 56, 1015-1019.
8. Emerich D. F., McDermott P., Krueger P., Banks M., Zhao J., Marszalkowski J., Frydel B., Winn S. R. and Sanberg P. R. (1993) Locomotion of aged rats: relationship to neurochemical but not morphological changes in nigrostriatal dopaminergic neurons. Brain Res. Bull., 32, 477-486.
9. Farabollini F., File S. E., Johnston A. L. and Wilson C. A. (1987) An analysis of sex differences in the open field and tests of exploration and anxiety. Br. J. Pharmacol 90, 263P.
10. File S. E. and Wardill A. G. (1975) Validity of head dipping as a measure of exploration in a modified hole-board. Psychopharmacologia (Berlin) 445, 53-59.
11. Friedemann M. N. and Gerhardt G. A. (1992) Regional effects of aging on dopaminergic function in the Fischer-344 rat. Neurobiol. Aging 13, 325-332.
12. Gage F. H., Dunnett S. B. and Bjorklund A. (1984) Spatial learning and motor deficits in aged rats. Neurobiol. Aging 5, 43-48.
13. Gray J. A. (1979) Emotionality in male and female rodents: a reply to Archer. Br. J. Psychol. 70, 425-440.
14. Green A. R., De Souza R. J., Williams J. L., Murray T. K. and Cross A. J. (1992) The neurotoxic effects of methamphetamine on 5-hydroxytryptamine and dopamine in brain: evidence for the protective effect of chlormethiazole. Neuropharmac. 31, 315-321.
15. Hollander C. F. and Mos J. (1986) The old animal as a model in research on brain aging and Alzheimer's disease/senile dementia of the Alzheimer type. In: Progress in Brain Research. Edited by Swaab, D. F., Fliers, E., Miramiran M., Van Gool W. A. and Van Haaren F. pp. 337-343. Elsevier Science, Amsterdam.
16. Johnston A. L. and File S. E. (1986) 5-HT and anxiety: promises and pitfalls. Pharmocol. Biochem. Behav. 24, 1467-1470.
17. Johnson H., Ulfhake B., Dagerlind A., Bennet G. W., Fone K. C. and Hokfelt T. (1993) The serotoninergic bulbospinal system and brainstem-spinal cord content of serotonin-, TRH-, and substance P-like immunoreactivity in the aged rat with special reference to the spinal cord motor nucleus. Synapse 15, 63-89.
18. Kubanis P. and Zornetzer S. F. (1981) Age-related behavioral and neurobiological changes: A review with an emphasis on memory. Behav. Neur. Biol. 31, 115-172.
19. Lipska B. K., Jaskiw G. E., Arya A. and Weinberger D. R. (1992) Serotonin depletion causes long-term reduction of exploration in the rat. Pharmacol. Biochem. Behav. 43, 1247-1252.
20. McNamara R. K. and Skelton R. W. (1993) The neuropharmacological and neurochemical basis of place learning in the Morris water maze. Brain Res. Rev. 18, 33-49.
21. Meller S. T., Lewis S. J., Brody M. J. and Gebhart G. F. (1992) Age, strain and anesthetic dependent differences in the nociceptive responses produced by i.v., 5-HT in the rat. Brain Res. 587, 88-94.
22. Millan M. J. (1990) κ-Opioid receptors and analgesia. Trends Pharmacol. Sci. 11, 70-75.
23. Montilla P., Salcedo M., Muñoz M. C. and Montilla M. C. (1991) Serotonina cerebral y sistema hipotalamo-hipofiso-adrenal de la rata en el envejecimiento. Rev. Esp. Fisiol. 47, 187-191.
24. Naranjo J. R., Sánchez-Franco F., Garzón J. and Del Río J. (1982) Analgesic activity of substance P in rats: apparent mediation by met-enkephalin release. Life Sci. 30, 441-446.
25. Olton D. S. (1990) Dementia: animal models of the cognitive impairments following damage to the basal forebrain cholinergic system. Brain Res. Bull. 25, 499-502.
26. Olton D. S. and Wenk G. L. (1987) Dementia: Animal models of the cognitive impairments produced by degeneration of the basal forebrain cholinergic system. In: Psychopharmacology: The Third Generation of Progress. Edited by Meltzer, H. Y., pp. 941-953. Raven Press, New York.
27. Reimann W., Bartoszyk G. D., Kollhofer U., Schneider F. and Schoenher U. (1993) Effects of aging and long-term operant conditioning on behavior and presynaptic cholinergic and dopaminergic neuronal mechanisms in rats. Arch. Int. Pharmacodyn. Ther. 325, 45-20.
28. Richter-Levin G. and Segal M. (1993) Age-related cognitive deficits in rats are associated with a combined loss of cholinergic and serotonergic functions. Ann. N. Y. Acad. Sci. 695, 254-257.
29. Rodríguez-Gómez J. A., De La Roza C., Machado A. and Cano J. (1995) The effect of age on the monoamine of the hipothalamus. Mech. Aging Dev. 77, 185-195.
30. Schmidt C., Xie J., Fournie-Zaluski M. C., Peyroux J. and Roques B. P. (1989) Antinociception and endogenous enkephalins. In: Advances in the Biosciences, vol. 75, pp. 475-478. Pergamon Press, Oxford.
31. Schuurman T., Horvath E., Spencer D. G. and Trabwer J. (1986) Old rats: an animal model for senile dementia. In: Senile Dementias: Early Detection. Edited by Bes A., pp. 624-630. John Libbey Eurotext, Paris.
32. Steenbergen H. L., Farabollini F., Heinsbroek R. P. and Van De Poll N. E. (1991) Sex-dependent effects of aversive stimulation on holeboard and elevated plus-maze behavior. Behav. Brain Res. 43, 159-165.
33. Van Luijtelaar M. G., Tonnaer J. A. and Steinbusch H. W. (1992) Aging of the serotonergic system in the rat forebrain: an immunocitochemical and neurochemical study. Neurobiol. Aging, 13, 201-215.
34. Venero J. L., De La Roza C., Machado A. and Cano J. (1993) Age-related changes on monoamine turnover in hippocampus of rats. Brain Res., 631, 89-96.
35. Venero J. L., Machado A. and Cano J. (1993b) Effect of aging on monoamine turnover in the prefrontal cortex of rats. Mech. Aging Dev. 72, 105-118.
36. Wilson C. A., Gónzalez I. and Farabollini F. (1991) Behavioral effects in adulthood of neonatal manipulation of brain serotonin levels in normal and androgenized females. Pharmocol. Biochem. Behav. 41, 91-98.
37. Yeung J. M. and Friedman E. (1991) Effect of aging and diet restriction on monoamines and amino acids in cerebral cortex of Fischer-344 rats. Growth Dev. Aging 55, 275-283.