NAD-dependent DNA-binding activity of the bifunctional NadR regulator of Salmonella typhimurium

Journal of Bacteriology

Volumn 181, Issue 2, 1999, Pages 648-655

  Penfound, Thomas ^a,b   Foster, John W ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; REGULATOR PROTEIN;

ARTICLE; BINDING SITE; COMPLEX FORMATION; DNA BINDING; DNA FOOTPRINTING; GENE REPRESSION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULON; SALMONELLA TYPHIMURIUM; SINGLE STRAND CONFORMATION POLYMORPHISM; TRANSCRIPTION REGULATION;

NEGIBACTERIA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0032925513     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.181.2.648-655.1999     Document Type: Article

References (35)

1. Barker, D. F., and A. M. Campbell. 1981. Genetic and biochemical characterization of the birA gene and its product: evidence for a direct role of biotin holoenzyme synthetase in repression of the biotin operon in Escherichia coli. J. Mol. Biol. 146:469-492.
2. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
3. Brenowitz, M., D. Senear, E. Jamison, and D. Dalma-Weiszhausz. 1993. Footprinting of nucleic acid-protein complexes. Academic Press, Inc., New York, N.Y.
4. Burgess, R. R. 1991. Use of polyethyleneimine in purification of DNA binding proteins. Methods Enzymol. 208:3-10.
5. Cook, R. J., R. S. Lloyd, and C. Wagner. 1991. Isolation and characterization of cDNA clones for rat liver 10-formyltetrahydrofolate dehydrogenase. J. Biol. Chem. 266:4965-4973.
6. Domenighini, M., C. Montecucco, W. C. Ripka, and R. Rappuoli. 1991. Computer modelling of the NAD binding sites of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding. Mol. Microbiol. 5:23-31.
7. Flachmann, R., N. Kunz, J. Seifert, M. Gütlich, F.-J. Wientjes, A. Läufer, and H. G. Gassen. 1988. Molecular biology of pyridine nucleotide biosynthesis in Escherichia coli: cloning and characterization of quinolinate synthesis genes nadA and nadB. Eur. J. Clin. Chem. Clin. Biochem. 175:221-228.
8. Foster, J. W., E. A. Holley-Guthrie, and F. Warren. 1987. Regulation of NAD metabolism in Salmonella typhimurium: genetic analysis and cloning of the nadR repressor locus. Mol. Gen. Genet. 208:279-287.
9. Foster, J. W., Y. K. Park, T. Penfound, T. Fenger, and M. P. Spector. 1990. Regulation of NAD metabolism in Salmonella typhimurium: molecular sequence analysis of the bifunctional nadR regulator and the nadA-pnuC operon. J. Bacteriol. 172:4187-4196.
10. Foster, J. W., and T. A. Penfound. 1993. The bifunctional NadR regulator of Salmonella typhimurium: location of regions involved with DNA binding, nucleotide transport and intramolecular communication. FEMS Microbiol. Lett. 112:179-184.
11. Fried, M. G., and D. M. Crothers. 1981. Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. Nucleic Acids Res. 9:6505-6525.
12. Garner, M., and A. Revzin. 1981. A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the E. coli lactose operon regulatory system. Nucleic Acids Res. 9:3047-3060.
13. Hackett, P. B., J. A. Fuchs, and J. W. Messing. 1984. An introduction to recombinant DNA techniques: basic experiments in gene manipulations. Benjamin/Cummings, Inc., Menlo Park, Calif.
14. Hempel, J., K. Harper, and R. Lindahl. 1988. Inducible (class 3) aldehyde dehydrogenase from rat hepatocellular carcinoma and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated liver: distant relationship to the class 1 and 2 enzymes from mammalian liver cytosol/mitochondria. Biochemistry 28:1160-1167.
15. Hidalgo, E., Y.-M. Chen, E. C. C. Lin, and J. Aguilar. 1991. Molecular cloning and DNA sequencing of the Escherichia coli K-12 ald gene encoding aldehyde dehydrogenase. J. Bacteriol. 173:6118-6123.
16. Hochschild, A. 1991. Detecting cooperative protein-DNA interactions and DNA loop formation by footprinting. Methods Enzymol. 208:343-361.
17. Holley, E. A., M. P. Spector, and J. W. Foster. 1985. Regulation of NAD biosynthesis in Salmonella typhimurium: expression of nad-lac gene fusions and identification of a nad regulatory locus. Microbiology 131:2759-2770.
18. Kinney, D. M., and J. W. Foster. 1985. Identification of cis-acting regulatory region in the pncB locus of Salmonella typhimurium. Mol. Gen. Genet. 199:512-517.
19. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
20. Liu, G., J. Foster, P. Manlapaz-Ramos, and B. M. Olivera. 1982. Nucleoside salvage pathway for NAD biosynthesis in Salmonella typhimurium. J. Bacteriol. 152:1111-1116.
21. Möller, W., and R. Amons. 1985. Phosphate-binding sequences in nucleotide binding proteins. FEBS Lett. 186:1-7.
22. Muro-Pastor, A. M., and S. Maloy. 1995. Proline dehydrogenase activity of the transcriptional repressor PutA is required for induction of the put operon by proline. J. Biol. Chem. 270:9819-9827.
23. Ostrovsky, P. C., and S. Maloy. 1995. Protein phosphorylation on serine, threonine, and tyrosine residues modulates membrane-protein interactions and transcriptional regulation in Salmonella typhimurium. Genes Dev. 9:2034-2041.
24. Spector, M. P., J. M. Hill, E. A. Holley, and J. W. Foster. 1985. Genetic characterization of pyridine nucleotide uptake mutants of Salmonella typhimurium. Microbiology 131:1313-1322.
25. Steele, M. I., D. Lorenz, K. Hatter, A. Park, and J. R. Sokatch. 1992. Characterization of the mmsAB operon of Pseudomonas aeruginosa PAO encoding methylmalonate-semialdehyde dehydrogenase and 3-hydroxyisobutyrate dehydrogenase. J. Biol. Chem. 267:13585-13592.
26. Tabor, S., and C. C. Richardson. 1985. A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. Proc. Natl. Acad. Sci. USA 82:1074-1078.
27. Tirgari, S., M. P. Spector, and J. W. Foster. 1986. Genetics of NAD metabolism in Salmonella typhimurium and cloning of the nadA and pnuC loci. J. Bacteriol. 167:1086-1088.
28. Tsai, S. P., R. J. Hartin, and J.-I. Ryu. 1989. Transformation in restriction-deficient Salmonella typhimurium LT2. J. Gen. Microbiol. 135:2561-2567.
29. Vinitsky, A., H. Teng, and C. T. Grubmeyer. 1991. Cloning and nucleic acid sequence of the Salmonella typhimurium pncB gene and structure of nicotinale phosphoribosyltransferase. J. Bacteriol. 173:536-540.
30. Vogel, H. J., and D. M. Bonner. 1956. Acetylornithase of Escherichia coli: partial purification and some properties. J. Biol. Chem. 218:97-106.
31. Weretilnyk, E. A., and A. D. Hanson. 1990. Molecular cloning of a plant hetaine-aldehyde dehydrogenase, an enzyme implicated in adaptation to salinity and drought. Proc. Natl. Acad. Sci. USA 87:2745-2749.
32. Wubbolts, M. G., P. Terpstra, J. B. Van Beilen, J. Kingma, H. A. R. Meesters, and B. Witholt. 1990. Variation of cofactor levels in Escherichia coli: sequence analysis and expression of the pncB gene encoding nicotinic acid phosphoribosyltransferase. J. Biol. Chem. 265:17665-17672.
33. Zhu, N., B. M. Olivera, and J. R. Roth. 1991. Activity of the nicotinamide mononucleotide transport system is regulated in Salmonella typhimurium. J. Bacteriol. 173:1311-1320.
34. Zhu, N., B. M. Olivera, and J. R. Roth. 1989. Genetic characterization of the pnuC gene, which encodes a component of the nicotinamide mononucleotide transport system in Salmonella typhimurium. J. Bacteriol. 171:4402-4409.
35. Zhu, N., B. M. Olivera, and J. R. Roth. 1988. Identification of a repressor gene involved in the regulation of NAD de novo biosynthesis in Salmonella typhimurium. J. Bacteriol. 170:117-125.