Evidence for differential regulation of renal proximal tubular p- aminohippurate and sodium-dependent dicarboxylate transport

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 2, 1999, Pages 710-715

  Gabriëls, Gert ^a,b   Werners, A ^a   Mauss, S ^a   Greven, J ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 AMINOHIPPURIC ACID; CYCLIC AMP DEPENDENT PROTEIN KINASE; DAIDZEIN; DICARBOXYLIC ACID; GENISTEIN; GLUTARIC ACID; INSULIN; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE C; PROTEIN TYROSINE KINASE INHIBITOR; SODIUM; WORTMANNIN;

ANIMAL TISSUE; ANION TRANSPORT; ARTICLE; BASOLATERAL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME REGULATION; KIDNEY PROXIMAL TUBULE; MALE; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RABBIT; REGULATORY MECHANISM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BIOLOGICAL TRANSPORT; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARRIER PROTEINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DICARBOXYLIC ACID TRANSPORTERS; DICARBOXYLIC ACIDS; ENZYME INHIBITORS; KIDNEY TUBULES, PROXIMAL; MALE; P-AMINOHIPPURIC ACID; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; RABBITS; SODIUM;

EID: 0345711507     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Abler A, Smith JA, Randazzo PA, Rothenberg PL and Jarrett L (1992) Genistein differentially inhibits postreceptor effects of insulin in rat adipocytes without inhibiting the insulin receptor kinase. J Biol Chem 267:3946-3951.
2. Alessi DR, Cuenda A, Cohen P, Dudley DT and Saltiel AR (1995) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270:27489-27494.
3. Barfuss SW and Schäfer JA (1979) Active amino acid absorption by proximal convoluted and proximal straight tubules. Am J Physiol 236:F149-F162.
4. 2 segments of rabbit kidney proximal tubules. J Pharmacol Exp Ther 266:972-977.
5. Boom SP, Gribnau FW and Russel FG (1992) Organic cation transport and cationic drug interactions in freshly isolated proximal tubular cells of the rat. J Pharmacol Exp Ther 263:445-450.
6. 2 proximal tubules: Characterization of transport mechanisms. J Pharmacol Exp Ther 258:1038-1045.
7. 2 proximal tubules: Cimetidine exchange studies. Arch Int Pharmacodyn Ther 314:169-185.
8. Brändle E and Greven J (1992) Transport of cimetidine across the basolateral membrane of rabbit proximal tubules: Interaction with organic anions. Pharmacology (Basel) 45:231-240.
9. Chatterjee S, Shi W, Wilson P and Mazumdar A (1996) Role of lactosylceramide and MAK kinase in the proliferation of proximal tubular cells in human polycystic kidney disease. J Lipid Res 37:1334-1344.
10. Chu T-S, Tsuganezawa H, Peng Y, Cano A, Yanagisawa M and Alpern RJ (1996) Role of tyrosine kinase pathways in ET B receptor activation of NHE3. Am J Physiol 271:C763-C771.
11. Derman MP, Cunha MJ, Barros EJG, Nigam SK and Cantley LC (1995) HGF-mediated chemotaxis and tubulogenesis require activation of the phosphatidylinositol 3-kinase. Am J Physiol 268: F1211-F1217.
12. Dudley DT, Pang L, Decker SJ, Bridges AJ and Saltiel AR (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 92:7686-7689.
13. +-ATPase: Mechanisms underlying rapid and sustained changes in pump activity. Am J Physiol 269:C295-C311.
14. +-ATPase activity by a tyrosine phosphorylation process in rat proximal convoluted tubule. J Physiol 498:99-108.
15. Gabriëls G, Krämer C, Stärk U and Greven J (1999) Role of the calcium/calmodulin-dependent protein kinase II in the regulation of the renal basolateral PAH and dicarboxylate transporters. Fundam Clin Pharmacol 13:59-66.
16. + exchange activity in proximal tubules from normotensive and hypertensive rats. Am J Physiol 260: F695-F703.
17. Good DW (1995) Hyperosmolality inhibits bicarbonate absorption in rat medullary thick ascending limb via a protein-tyrosine kinase-dependent pathway. J Biol Chem 270:9883-9889.
18. Heasley LE, Senkfor SI, Winitz S, Strasheim A, Teitelbaum I and Berl T (1994) Hormonal regulation of MAP kinase in cultured rat inner collecting tubule cells. Am J Physiol 267: F366-F373.
19. Hohage H, Löhr M, Querl IU and Greven J (1994) The renal basolateral transport system for organic anions: Properties of the regulation mechanism. J Pharmacol Exp Ther 269:659-664.
20. Hohage H, Querl IU, Mörth DM and Greven J (1996) The basolateral organic cation transport system of rabbit kidney proximal tubules. Influence of anorganic anions. J Pharmacol Exp Ther 279:1086-1091.
21. Ito O, Kondo Y, Oba M, Takahashi N, Omata K and Abe K (1997) Tyrosine kinase, phosphatidylinositol 3-kinase, and protein kinase C regulate insulin-stimulated NaCl absorption in the thick ascending limb. Kidney Int 51:1037-1041.
22. Kapeller R and Cantley LC (1994) Phosphatidylinositol 3-kinase. BioEssays 16:565-576.
23. Kutzer M, Meer S, Haller S and Greven J (1996) Basolateral glutarate transport by isolated S2 segments of rabbit kidney proximal tubules. J Pharmacol Exp Ther 277:316-320.
24. Li G, D'Souza-Schorey C, Barbieri MA, Roberts RL Klippel A, Williams LT and Stahl PD (1995) Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5. Proc Natl Acad Sci USA 92:10207-10211.
25. Moule SK and Denton RM (1997) Multiple signaling pathways involved in the metabolic effects of insulin. Am J Cardiol 80:41A-49A.
26. Pajor AM (1996) Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney. Am J Physiol 270:F642-F648.
27. Pritchard JB (1990) Rat renal cortical slices demonstrate p-amino-hippurate/ glutarate exchange and sodium/glutarate coupled p-aminohippurate transport. J Pharmacol Exp Ther 255:969-975.
28. Record RD, Johnson M, Lee S and Blazer-Yost BL (1996) Aldosterone and insulin stimulate amiloride-sensitive sodium transport in A6 cells by additive mechanisms. Am J Physiol 271:C1079-C1084.
29. Reid G, Wolff NA, Dautzenberg F and Burckhardt G (1998) Cloning of a human renal p-aminohippurate transporter, hROAT1. Kidney Blood Press Res 21:233-237.
30. 2 segments of rabbit kidney: Kinetics of the uptake process and effect of activators of protein kinase A and C. Pflügers Arch Eur J Physiol 436:423-428.
31. Roth RA, Zhang B, Chin JE and Kovacina K (1992) Substrates and signalling complexes: The tortured path to insulin action. J Cell Biochem 48:12-18.
32. Scrimgeour AG, Blakesley VA, Stannard BS and LeRoith D (1997) Mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways are not sufficient for insulin-like growth factor I-induced mitogenesis and tumorigenesis. Endocrinology 138:2552-2558.
33. Sekine T, Watanabe N, Hosoyamada M, Kanai Y and Endou H (1997) Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 272:18526-18529.
34. Sheperd PR, Nave BT, Rincon J, Haigh RJ, Foulstone E, Proud C, Zierath JR, Siddle K and Wallberg-Henriksson H (1997) Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: Implications for glucose metabolism. Diabetologia 40: 1172-1177.
35. + of p-aminohippuric acid uptake into rat renal basolateral membrane vesicles. Am J Physiol 253:F795-F801.
36. Shuba LM, Asai T, Pelzer S and McDonald TF (1996) Activation of cardiac chloride conductance by the tyrosine kinase inhibitor, genistein. Br J Pharmacol 119:335-345.
37. Stärk U, Vanden Bergh J, Röver N and Greven J (1998) Effect of activation of protein kinases A and C on the kinetics of the renal basolateral PAH transporter. Fundam Clin Pharmacol 12:44-49.
38. Sweet DH, Wolff NA and Pritchard JB (1997) Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J Biol Chem 272:30088-30095.
39. Terada Y, Tomita K, Homma MK, Nonoguchi H, Yang T, Yamada T, Yuasa Y, Krebs EG and Marumo F (1995) Sequential activation of MAP kinase cascade by angiotensin II in opossum kidney cells. Kidney Int 48:1801-1809.
40. Takano M, Nagai J, Yasuhara M and Inui KI (1996) Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cell. Am J Physiol 271: F469-F475.
41. Ui M, Okada T, Hazeki K and Hazeki O (1995) Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biochem Sci 20:303-306.
42. von Willebrand M, Jascur T, Bonnefoy-Bërard N, Yano H, Altman A, Matsuda Y and Mustelin T (1996) Inhibition of phosphatidylinositol 3-kinase blocks T cell antigen receptor/CD3-induced activation of the mitogen-activated kinase ERK2. Eur J Biochem 235:828-835.
43. Waters SB, Holt KH, Ross SE, Syu L-J, Guan K-L, Saltiel AR, Koretzky GA and Pessin JE (1995) Desensitization of Ras activation by a feedback disassociation if the SOS-Grb2 complex. J Biol Chem 270:20883-20886.
44. White MF and Kahn CR (1994) The insulin signaling system. J Biol Chem 269:1-4.
45. Wong R, Heasley L and Berl T (1995) Expression of GTPase-deficient RAS inhibits vaaopressin signaling in cultured cortical collecting duct cells. J Clin Invest 96: 597-601.
46. Zheng X-L, Mokashi S and Hollenberg MD (1998) Contractile action of ethanol in guinea pig gastric smooth muscle: Inhibition by tyrosine kinase inhibitors and comparison with the contractile action of epidermal growth factor-urogastrone. J Pharmacol Exp Ther 285:325-334.