Safety and therapeutic efficacy of artesunate suppositories for treatment of malaria in children in Papua New Guinea

Pediatric Infectious Disease Journal

Volumn 22, Issue 3, 2003, Pages 251-255

  Karunajeewa, Harin A ^a   Kemiki, Adedayo ^c   Alpers, Michael P ^b,d   Lorry, Kerry ^d   Batty, Kevin T ^b   Ilett, Kenneth F ^a   Davis, Timothy M E ^a,e  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b CURTIN UNIVERSITY   (Australia)

^c Modilon General Hospital   (Papua New Guinea)

^d PAPUA NEW GUINEA INSTITUTE OF MEDICAL RESEARCH   (Papua New Guinea)

^e FREMANTLE HOSPITAL   (Australia)

Author keywords

Artesunate; Children; Falciparum malaria; Suppositories; Vivax malaria

Indexed keywords

ARTESUNATE; CHLOROQUINE; FANSIDAR; PLASMOTRIM RECTOCAPS; QUININE;

ARTICLE; BLOOD SMEAR; CHILD; CLINICAL TRIAL; DISEASE COURSE; DRUG EFFICACY; DRUG MIXTURE; DRUG MONITORING; DRUG SAFETY; DRUG TOLERABILITY; ERADICATION THERAPY; FEMALE; FEVER; HUMAN; HYPERPYREXIA; MAJOR CLINICAL STUDY; MALARIA; MALE; PAPUA NEW GUINEA; PARASITEMIA; PHASE 2 CLINICAL TRIAL; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PRIORITY JOURNAL; SUPPOSITORY; TACHYCARDIA; VOMITING;

EID: 0345700327     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.inf.0000054826.80221.75     Document Type: Article

References (21)

1. Hien T, White N. Qinghaosu. Lancet 1993;341:603-7.
2. Special Programme for Research and Training in Tropical Diseases. 15th Programme Report. Progress 1999-2000. TDR/GEN/01.5.
3. Looareesuwan S, Wilairatana P, Vanijanonta S, Viravan C, Andrial M. Efficacy and tolerability of a sequential, artesunate suppository plus mefloquine, treatment of severe falciparum malaria. Ann Trop Med Parasitol 1995;89:469-75.
4. Looareesuwan S, Wilairatana P, Molunto W, Chalermrut K, Olliaro P, Andrial M. A comparative clinical trial of sequential treatments of severe malaria with artesunate suppository followed by mefloquine in Thailand. Am J Trop Med Hyg 1997;57:348-53.
5. Krishna S, Planche T, Agbenyega T, et al. Bioavailability and preliminary clinical efficacy of intrarectal artesunate in Ghanaian children with moderate malaria. Antimicrob Agents Chemother 2001;45:509-16.
6. Halpaap B, Ndjave M, Paris M, Benakis A, Kremsner PG. Plasma levels of artesunate and dihydroartemisinin in children with Plasmodium falciparum malaria in Gabon after administration of 50-milligram artesunate suppositories. Am J Trop Med Hyg 1998;58:365-8.
7. Sabchareon A, Attanath P, Chanthavanich P, et al. Comparative clinical trial of artesunate suppositories and oral artesunate in combination with mefloquine in the treatment of children with acute falciparum malaria. Am J Trop Med Hyg 1998;58:11-16.
8. Seaton RA, Trevett AJ, Wembri JP, et al. Randomized comparison of intramuscular artemether and intravenous quinine in adult, Melanesian patients with severe or complicated Plasmodium falciparum malaria in Papua New Guinea. Ann Trop Med Parasitol 1998;92:133-9.
9. Moir JS, Garner PA, Heywood PF, Alpers MP. Mortality in a rural area of Madang Province, Papua New Guinea. Ann Trop Med Parasitol 1989;83:305-19.
10. World Health Organization. Severe falciparum malaria. Trans R Soc Trop Med Hyg 2000;94(Suppl 1):1-90.
11. Dean A, Dean J, Coulombier D, et al. Epi-Info. 6.04 ed. Atlanta: Centers for Disease Control and Prevention, 1997.
12. McIntosh H, Olliaro P. Artemisinin derivatives for treating uncomplicated malaria (Cochrane review). Oxford: Update Software, 2001.
13. White NJ, Krishna S. Treatment of malaria: some considerations and limitations of the current methods of assessment. Trans R Soc Trop Med Hyg 1989;83:767-77.
14. Okonkwo CA, Coker HA, Agomo PU, et al. Effect of chlorpheniramine on the pharmacokinetics of and response to chloroquine of Nigerian children with falciparum malaria. Trans R Soc Trop Med Hyg 1999;93:306-11.
15. Penali LK, Assi-Coulibaly L, Kaptue B, Konan D, Ehouman A. Parasitological and clinical response to amodiaquine versus chloroquine in the treatment of Plasmodium falciparum malaria in children in an endemic area. Bull Soc Pathol Exot 1994;87:244-7.
16. Adagu SI, Okoyeh JN, Lege-Oguntoye L, et al. Efficacy of a 3-day oral regimen of quinine in an area of northern Nigeria with low-grade resistance of Plasmodium falciparum to chloroquine and sulfadoxine-pyrimethamine. J Trop Med Hyg 1995;98:296-8.
17. White NJ. Artemisinin: current status. Trans R Soc Trop Med Hyg 1994;88(Suppl 1):3-4.
18. Denis MB, Davis TME, Hewitt S, et al. Efficacy and safety of dihydroartemisinin plus piperaquine (Artekin®) in Cambodian children and adults with uncomplicated falciparum malaria. Clin Infect Dis 2002;35:1469-76.
19. Davis TME, Batty KT, Ilett KF, et al. Pharmacokinetics and pharmacodynamics of intravenous artesunate in severe falciparum malaria. Antimicrob Agents Chemother 2001;45:181-6.
20. Barradell LB, Fitton A. Artesunate: a review of its pharmacology and therapeutic efficacy in the treatment of malaria. Drugs 1995;50:714-41.
21. Kidane G, Morrow RH. Teaching mothers to provide home treatment of malaria in Tigray, Ethiopia: a randomised trial. Lancet 2000;356:550-5.