Correlation of Serum Leptin Concentrations with Body Composition and Gender in Taiwanese Hemodialysis Patients without Diabetes

Renal Failure

Volumn 25, Issue 6, 2003, Pages 953-966

  Wang, Jenn Yeu ^a   Lu, Kuo Cheng ^b   Lin, Yuh Feng ^b,c   Hu, Wei Ming ^a  

^a Taipei Municipal Chung Hsiao Hospital   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Bioelectrical impedance; Body composition; Gender; Hemodialysis; Leptin

Indexed keywords

ALBUMIN; LEPTIN; TRANSFERRIN;

ADULT; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; BODY COMPOSITION; BODY FAT; BODY HEIGHT; BODY MASS; BODY WEIGHT; CALCULATION; CELL MEMBRANE STEADY POTENTIAL; CORRELATION ANALYSIS; DIABETES MELLITUS; DISEASE MARKER; FEMALE; GENDER; HEMODIALYSIS; HUMAN; IMPEDANCE; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; NUTRITIONAL STATUS; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN MALNUTRITION; RADIOIMMUNOASSAY; SEX DIFFERENCE; TAIWAN; TOTAL BODY WATER; TRANSFERRIN BLOOD LEVEL;

ADULT; AGED; BIOLOGICAL MARKERS; BODY COMPOSITION; BODY MASS INDEX; CASE-CONTROL STUDIES; COHORT STUDIES; DIABETIC NEPHROPATHIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; KIDNEY FAILURE, CHRONIC; LEPTIN; MALE; MIDDLE AGED; PROBABILITY; RADIOIMMUNOASSAY; REFERENCE VALUES; RENAL DIALYSIS; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SEX FACTORS; TAIWAN; TREATMENT OUTCOME;

EID: 0345688696     PISSN: 0886022X     EISSN: None     Source Type: Journal    
DOI: 10.1081/JDI-120026030     Document Type: Article

References (48)

1. Friedman, J.M. Leptin, leptin receptors, and the control of body weight. Nutr. Rev. 1998, 56 (2), S38-S46.
2. Caro, J.F.; Sinha, M.K.; Kolaczynski, J.W.; Zhang, P.L.; Considine, R.V. Leptin - the tale of an obesity gene. Diabetes 1996, 45, 455-1462.
3. Sharma, K.; Considine, R.V. The Ob protein (leptin) and the kidney. Kidney Int. 1998, 53, 1483-1487.
4. Ostlund, R.E., Jr.; Yang, J.W.; Klein, S.; Gingerich, R. Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J. Clin. Endocrinol. Metab. 1996, 81, 3909-3913.
5. Considine, R.V.; Sinha, M.K.; Heiman, M.L.; Kriaugiunas, A.; Stephens, T.W.; Nyce, M.R.; Ohannesian, J.P.; Marco, C.C.; McKee, L.J.; Bauer, T.L.; Caro, J.F. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New Engl. J. Med. 1996, 334, 292-295.
6. Heimburger, O.; Lonnqvist, F.; Danielsson, A.; Nordenstrom, J.; Stenvinkel, P. Serum immunoreactive leptin concentration and its relation to the body fat content in chronic renal failure. J. Am. Soc. Nephrol. 1997, 8, 1423-1430.
7. Johansen, K.L.; Mulligan, K.; Tai, V.; Schambelan, M. Leptin, body composition, and indices of malnutrition in patients on dialysis. J. Am. Soc. Nephrol. 1998, 9, 1080-1084.
8. Merabet, E.; Dagogo-Jack, S.; Coyne, D.W.; Klein, S.; Santiago, J.V.; Hmiel, S.P.; Landt, M. Increased plasma leptin concentration in end-stage renal disease. J. Clin. Endocrinol. Metab. 1997, 82, 847-850.
9. Nakazono, H.; Nagake, Y.; Ichikawa, H.; Makino, H. Serum leptin concentrations in patients on hemodialysis. Nephron 1998, 80, 35-40.
10. Haluzik, M.; Sulkova, S.; Svobodova, J.; Bedarova, V.; Bodlakova, B.; Markova, M.; Turkova, G.; Jiskra, J.; Haas, T. Serum leptin levels in diabetic patients on hemodialysis: the relationship to parameters of diabetes metabolic control. Endocr. Res. 2000, 26 (2), 303-317.
11. Rosenbaum, M.; Nicolson, M.; Hirsch, J.; Heymsfield, S.B.; Gallagher, D. ; Chu, F.; Leibel, R.L. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J. Clin. Endocrinol. Metab. 1996, 81, 3424-3427.
12. Roemmich, J.N.; Clark, P.A.; Berr, S.S.; Mai, V.; Mantzoros, C.S.; Flier, J.S.; Weltman, A.; Rogol, A.D. Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids. Am. Physiol. Soc. 1998, E543-E551.
13. Nishizawa, Y.; Shoji, T.; Tanaka, S.; Yamashita, M.; Morita, A.; Emoto, M.; Tabata, T.; Inoue, T.; Morii, H. Plasma leptin level and its relationship with body composition in hemodialysis patients. Am. J. Kidney Dis. 1998, 31 (4), 655-661.
14. Chertow, G.M.; Lowrie, E.G.; Wilmore, D.W.; Gonzalez, J.; Lew, N.L.; Ling, J.; Leboff, M.S.; Gottlieb, M.N.; Huang, W.; Zebrowski, B.; College, J.; Lazarus, J.M. Nutritional assessment with bioelectrical impedance analysis in maintenance hemodialysis patients. J. Am. Soc. Nephrol. 1995, 6, 75-81.
15. de Fijter, W.M.; de Fijter, C.W.H.; Oe, P.L.; ter Wee, P.M.; Donker, A.J.M. Assessment of total body water and lean body mass from anthropometry, Watson formula, creatinine kinetics, and body electrical impedance compared with antipyrine kinetics in peritoneal dialysis patients. Nephrol. Dial. Transplant. 1997, 12, 151-156.
16. Wang, J.; Thornton, J.C.; Russell, M.; Burastero, S.; Heymsfield, S.; Pierson, R.N., Jr. Asians have lower body mass index (BMI) but higher percent body fat than do whites: comparisons of anthropometric measurements. Am. J. Clin. Nutr. 1994, 60, 23-28.
17. He, M.; Tan, K.C.B.; Li, E.T.S.; Kung, A.W.C. Body fat determination by dual energy X-ray absorptionmetry and its relation to body mass index and waist circumference in Hong Kong Chinese. Int. J. Obesity 2001, 25, 748-752.
18. Steering Committee of the WHO Western Pacific Region, IASO & IOTF. The Asia-Pacific perspective: redefining obesity and its treatment. Australia 2000.
19. Dallongeville, J.; Fruchart, J.-C.; Auwerx, J. Leptin, a pleiotropic hormone: physiology, pharmacology, and strategies for discovery of leptin modulators. J. Med. Chem. 1998, 41 (27), 5337-5352.
20. Kolaczynski, J.W.; Nyce, M.R.; Considine, R.V.; Boden, G.; Nolan, J.J.; Henry, R.; Mudaliar, S.R.; Olefsky, J.; Caro, J.F. Acute and chronic effect of insulin on leptin production in humans. Diabetes 1996, 45, 699-701.
21. Shoji, T.; Nishizawa, Y.; Emoto, M.; Maekawa, K.; Hiura, Y.; Tanaka, S.; Kawagishi, T.; Okuno, Y.; Morii, H. Renal funtion and insulin resistance as determinants of plasma leptin levels in patients with NIDDM. Diabetologia 1997, 40, 676-679.
22. Fontan, M.P.; Carmona-Rodriguez, A.; Cordido, F.; Garcia-Buela, J. Hyperleptinemia in uremic patients undergoing conservative management, peritoneal dialysis, and hemodialysis: a comparative analysis. Am. J. Kidney Dis. 1999, 34 (5), 824-831.
23. Meyer, C.; Robson, D.; Rackovsky, N.; Nadkarni, V.; Gerich, J. Role of the kidney in human leptin metabolism. Am. J. Physiol. 1997, 273 (Endcrinol. Metal 36), E903-E907.
24. Jensen, M.D.; Moller, N.; Nair, K.S.; Eisenberg, P.; Landt, M.; Klein, S. Regional leptin kinetics in humans. Am. J. Clin. Nutr. 1999, 69, 18-21.
25. Williams, L.B.; Fawcett, R.L.; Waechter, A.S.; Zhang, P.; Kogon, B.E.; Jones, R.; Inman, M.; Huse, J.; Considine, R.V. Leptin production in adipocytes from morbidly obese subjects: stimulation by dexamethasone, inhibition with troglitazone, and influence of gender. J. Clin. Endocrinol. Metab. 2000, 85, 2678-2684.
26. Casabiell, X.; Pineiro, V.; Peino, R.; Lage, M.; Camina, J.; Gallego, R. ; Vallejo, L.G.; Dieguez, C.; Casanueva, F.F. Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradial stimulate leptin release in women, but not in men. J. Clin. Endocrinol. Metab. 1998, 83, 2149-2155.
27. Wabitsch, M.; Blum, W.F.; Muche, R.; Braun, M.; Hube, F.; Rascher, W.; Heinze, E.; Teller, W.; Hauner, H. Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J. Clin. Invest. 1997, 100, 808-813.
28. Considine, R.V.; Cooksey, R.C.; Williams, L.B.; Fawcett, R.L.; Zhang, P. ; Ambrosius, W.T.; Whitfield, R.M.; Jones, R.; Inman, M.; Huse, J.; Mcclain, D.A. Hexosamine regulate leptin production in human subcutaneous adipocytes. J. Clin. Endocinol. Metab. 2000, 85, 3551-3556.
29. Couillard, C.; Mauriege, P.; Imbeault, P.; Prud'homme, D.; Nadeau, A.; Tremblay, A.; Bouchard, C.; Despres, J.-P. Hyperleptinemia in more closely associated with adipose cell hypertrophy than with adipose tissue hyperplasia. Int. J. Obesity 2000, 24, 782-788.
30. Sheu, W.H.-H.; Lee, W.J.; Chen, Y.-T. Gender differences in relation to leptin concentration and insulin sensitivity in nondiabetic Chinese subjects. Int. J. Obesity 1999, 23, 754-759.
31. Fernandez-Real, J.-M.; Vayreda, M.; Casamitjana, R.; Gonzalez-Huix, F.; Ricart, W. The fat-free mass compartment influences serum leptin in men. Eur. J. Endocrinol. 2000, 142, 25-29.
32. Wiesholzer, M.; Harm, F.; Hauser, A.-C.; Pribasnig, A.; Balcke, P. Inappropriately high plasma leptin levels in obese haemodialysis patients can be reduced by high flux haemodialysis and haemodiafiltration. Clin. Sci. 1998, 94, 431-435.
33. Kokot, F.; Wiecek, A.; Mesjasz, J.; Adamczak, M.; Spiechowicz, U. Influence of long-term recombinant human erythropoietin (rHuEpo) therapy on plasma leptin and neuropeptide Y concentration in haemodialysed uraemic patients. Nephrol. Dial. Transplant. 1998, 13, 1200-1205.
34. Malyszko, J.; Zbroch, E.; Wolczynski, S.; Malyszko, J.S.; Hryszko, T.; Mysliwiec, M. Leptin and serum erythropoietin in hemodialyzed and peritoneally dialyzed uremic patients during rHuEPO therapy. Am. J. Nephrol. 2000, 20, 180-186.
35. Kokot, F.; Samardzija, G.; Klimek, D.; Wiecek, A. Intravenous single dose of erythropoietin (rHuEPO) does not influence plasma leptin concentration in hemodialyzed patients with chronic renal failure (CRF). Clin. Nephrol. 1999, 51 (6), 389-391.
36. Deurenberg, P.; Yap, M.D.; Wang, J.; Lin, F.P.; Schmidt, G. The impact of body build on the relationship between body mass index and percent body fat. Int. J. Obesity 1999, 23, 537-542.
37. Deurenberg, P.; Yap, M.; van Staveren, W.A. Body mass index and percent body fat: a metaanalysis among different ethnic groups. Int. J. Obesity 1998, 22, 1164-1171.
38. Stall, S.; Ginsberg, N.S.; DeVita, M.V.; Zabetakis, P.M.; Lynn, R.I.; Gleim, G.W.; Wang, J.; Pierson, R.N., Jr.; Michelis, M.F. Percentage body fat determination in hemodialysis and peritoneal dialysis patients: a comparison. J. Renal. Nutri. 1998, 8 (3), 132-136.
39. Hellstrom, L.; Wahrenberg, H.; Hruska, K.; Reynisdottir, S.; Arner, P. Mechanisms behind gender differences in circulating leptin levels. J. Intern. Med. 2000, 247, 457-462.
40. Fruehwald-Schultes, B.; Peters, A.; Kern, W.; Beyer, J.; Pfutzner, A. Influence of sex differences in subcutaneous fat mass on serum leptin concentrations. Diabetes Care 1998, 21 (7), 1204-1205.
41. Blum, W.F.; Englaro, P.; Hanitsch, S.; Juul, A.; Hertel, N.T.; Muller, J.; Skakkebaek, N.E.; Heiman, M.L.; Birkett, M.; Attanasio, A.M.; Kiess, W. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J. Clin. Endocrinol. Metab. 1997, 82, 2904-2910.
42. Erfurth, E.M.; Ahren, B. The negative association between serum free testosterone and leptin is dependent on insulin-like growth factor-binding protein 1 in healthy young and middle aged men. Clin. Endocrinol. 2000, 52, 493-498.
43. Wabitsch, M.; Blum, W.F.; Muche, R.; Braun, M.; Hube, F.; Rascher, W.; Heinze, E.; Teller, W.; Hauner, H. Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J. Clin. Invest. 1997, 100, 808-813.
44. Pedersen, S.B.; Fuglsig, S.; Sjogren, P.; Richelsen, B. Identification of steroid receptors in human adipose tissue. Eur. J. Clin. Invest. 1996, 26, 1051-1056.
45. Elbers, J.M.H.; Asscheman, H.; Seidell, J.C.; Frolich, M.; Meinders, A.E.; Gooren, L.J.G. Reversal of the sex difference in serum leptin levels upon cross-sex hormone administration in transsexuals. J. Clin. Endocrinol. Metab. 1997, 82, 3267-3270.
46. Jockenhovel, F.; Blum, W.F.; Vogel, E.; Englaro, P.; Muller-Wieland, D.; Reinwein, D.; Rascher, W.; Krone, W. Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men. J. Clin. Endocrinol. Metab. 1997, 82, 2510-2513.
47. Blumenkrantz, M.J.; Kopple, J.D.; Gutman, R.A.; Chan, Y.K.; Barbour, G.L.; Roberts, C.; Shen, F.H.; Gandhi, V.C.; Tucker, T.; Curtis, F.K.; Coburn, J.W. Methods for assessing nutritional status of patients with renal failure. Am. J. Clin. Nutri. 1980, 33, 1567-1585.
48. Lazarus, J.M. Nutrition in hemodialysis patients. Am. J. Kidney Dis. 1993, 21 (1), 99-105.