Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke

Cancer Research

Volumn 63, Issue 4, 2003, Pages 793-800

  De Flora, Silvio ^a   Balansky, Roumen M ^a,d   D'Agostini, Francesco ^a   Izzotti, Alberto ^a   Camoirano, Anna ^a   Bennicelli, Carlo ^a   Zhang, Zhongqiu ^b   Wang, Yian ^b   Lubet, Ronald A ^c   You, Ming ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d National Oncology Center Bulgaria   (Bulgaria)

Author keywords

[No Author keywords available]

Indexed keywords

CIGARETTE SMOKE; DNA; PROTEIN P53;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANIMAL USE; APOPTOSIS; ARTICLE; BRONCHUS MUCOSA; CANCER INCIDENCE; CARCINOGENICITY; CELL PROLIFERATION; CHROMOSOME DAMAGE; CIGARETTE SMOKING; CONTROLLED STUDY; CONVALESCENCE; DNA ADDUCT; DNA DAMAGE; ENVIRONMENTAL EXPOSURE; ERYTHROCYTE; FEMALE; GENE MUTATION; HEART; LUNG; LUNG ALVEOLUS MACROPHAGE; LUNG CARCINOGENESIS; LUNG TUMOR; MALE; MICRONUCLEUS; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTECTION; TRANSGENIC MOUSE; WEIGHT GAIN;

ANIMALS; APOPTOSIS; CELL DIVISION; COCARCINOGENESIS; DISEASE MODELS, ANIMAL; DNA ADDUCTS; DNA DAMAGE; FEMALE; GENES, P53; GENETIC PREDISPOSITION TO DISEASE; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED A; MICE, TRANSGENIC; MUTATION; MYOCARDIUM; SMOKE; TOBACCO; TUMOR SUPPRESSOR PROTEIN P53; WEIGHT GAIN;

EID: 0037443032     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Doll, R., and Peto, R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J. Natl. Cancer Inst., 66: 1192-1308, 1981.
2. Tobacco smoking, IARC Monographs on the Evaluation of the Carcinogenic Risk to Humans. Vol. 38. Lyon, France: IARC, 1986.
3. United States Department of Health and Human Services. Reducing the health consequences of smoking, 25 years of progress. In: Office on Smoking and Health DHSS Publication No. CDC-89-8411, pp. 43-54. Washington, DC: Government Printing Office, 1989.
4. Hecht, S. S. Tobacco smoke carcinogenesis and lung cancer. J. Natl. Cancer Inst., 91: 1194-1210, 1999.
5. Coggins, C. R. E. A review of the chronic inhalation studies with mainstream cigarette smoke in rats and mice. Toxicol. Pathol., 26: 307-314, 1998.
6. Rubin, H. Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: A bio-historical perspective with updates. Carcinogenesis (Lond.), 22: 1903-1930, 2001.
7. Mohtashamipur, E., Mohtashamipur, A., Germann, P. G., Ernst, H., Norpoth, K., and Mohr, U. Comparative carcinogenicity of cigarette mainstream and sidestream smoke condensates on the mouse skin. J. Cancer Res. Clin. Oncol., 116: 604-608, 1990.
8. Henry, C. J., and Kouri, R. E. Chronic inhalation studies in mice. II. Effects of long-term exposure to 2R1 cigarette smoke on (C57BL/Cum x C3H/AnfCum)F1 mice. J. Natl. Cancer Inst., 77: 203-212, 1986.
9. Leuchtenberger, C., and Leuchtenberger, R. Differential response of Snell's and C57 black mice to chronic inhalation of cigarette smoke. Pulmonary carcinogenesis and vascular alterations in lung and heart. Oncology, 29: 122-138, 1974.
10. D'Agostini, F., Balansky, R. M., Pesce, C. M., Fiallo, P., Lubet, R. A., Kelloff, G. J., and De Flora, S. Induction of alopecia in mice exposed to cigarette smoke. Toxicol. Lett., 114: 117-123, 2000.
11. D'Agostini, F., Balansky, R. M., Bennicelli, C., Lubet, R. A., Kelloff, G. J., and De Flora, S. Pilot studies evaluating the lung tumour yield in cigarette smoke-exposed mice. Int. J. Oncol., 18: 607-615, 2001.
12. De Flora, S., D'Agostini, F., Balansky, R., Camoirano, A., Bennicelli, C., Bagnasco, M., Cartiglia, C., Tampa, E., Longobardi, M. G., Lubet R. A., and Izzotti, A. Modulation of cigarette smoke-related end-points in mutagenesis and carcinogenesis. Mutat. Res., in press, 2003.
13. Witschi, H., Esperitu, I., Dance, S. T., and Miller, M. S. A mouse lung tumour model of tobacco carcinogenesis. Toxicol. Sci., 68: 322-330, 2002.
14. Shimkin, M. B., and Stoner, G. D. The genetic basis of susceptibility to lung tumours in mice. Adv. Cancer Res., 21: 1-56, 1975.
15. Manenti, G., Gariboldi, M., Fiorino, A., Zanesi, N., Pierotti, M. A., and Dragani, T. A. Genetic mapping of lung cancer modifier loci specifically affecting tumour initiation and progression. Cancer Res., 57: 4164-4166, 1997.
16. Malkinson, A. M. Primary lung tumours in mice: an experimentally manipulable model of human adenocarcinoma. Cancer Res., 52(Suppl.): 2670s-2676s, 1992.
17. Essenberg, J. M. Cigarette smoke and the incidence of primary neoplasm of the lung in the albino mouse. Science (Wash. DC). 116: 561-562, 1952.
18. Finch, G. L., Nikula, K. J., Belinsky, S. A., Barr, E. B., Stoner, G. D., and Lechner, J. F. Failure of cigarette smoke to induce or promote lung cancer in the A/J mouse. Cancer Lett., 99: 161-167, 1996.
19. Witschi, H. P. Successful and not so successful chemoprevention of tobacco smoke-induced lung tumours. Exp. Lung Res., 26: 743-755, 2000.
20. Witschi, H., Esperitu, I., Peake, J. L., Wu, K., Maronpot, R. R., and Pinkerton, K. E. The carcinogenicity of environmental tobacco smoke. Carcinogenesis (Lond.), 18: 575-586, 1997.
21. Witschi, H. P., Espiritu, I., Maronpot, R. R., Pinkerton, K. E., and Jones, A. D. The carcinogenic potential of the gas phase of environmental tobacco smoke. Carcinogenesis (Lond.), 18: 2035-2042, 1997.
22. th Congr. Eur. Soc. Toxicol. (Eurotox 2002), Budapest, Hungary, September 15-18, 2002.
23. D'Agostini, F., Balansky, R. M., Izzotti, A., Lubet, R. A., Kelloff, G. J., and De Flora, S. Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats. Carcinogenesis (Lond.), 22: 375-380, 2001.
24. Hursting, S. D., Perkins, S. N., Donehower, L. A., and Davis, B. J. Cancer prevention studies in p53-deficient mice. Toxicol. Pathol., 29: 137-141, 2001.
25. Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell, 88: 323-331, 1997.
26. Wang, X. W., and Harris, C. C. p53 tumor-suppressor gene: clues to molecular carcinogenesis. J. Cell. Physiol., 173: 247-255, 1997.
27. Matzinger, S. A., Crist, K. A., Stoner, G. D., Anderson, M. W., Pereira, M. A., Steele, V. E., Kelloff, G. J., Lubet, R. A., and You, M. K-ras mutations in lung tumors from A/J and (UL53-3 x A/J)F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate. Carcinogenesis (Lond.), 16: 2487-2492, 1995.
28. Zhang, Z., Liu, K., Lantry, L. E., Wang, Y., Kelloff, G. J., Anderson, M. W., Wiseman, R. W., Lubet, R. A., and You, M. A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin. Cancer Res., 60: 901-907, 2000.
29. Harvey, M., Vogel, H., Morris, D., Bradley, A., Bernstein, A., and Donehower, L. A. A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice. Nat. Gen., 9: 305-311, 1995.
30. Lubet, R. A., Zhang, Z., Wiseman, R. W., and You, M. Use of p53 transgenic mice in the development of cancer models for multiple purposes. Exp. Lung. Res., 26: 581-593, 2000.
31. Zhang, Z., Li, J., Lantry, L. E., Wang, Y., Wiseman, R. W., Lubet, R. A., and You, M. p53 transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas. Cancer Res., 62: 3024-3029, 2002.
32. Teague, S. V., Pinkerton, K. E., Goldsmith, M., Gebremichael, A., Chang, S., Jenkins, R. A., and Moneyhum, J. H. Sidestream cigarette smoke generation and exposure system for environmental tobacco smoke studies. Inhal. Toxicol., 6: 79-93, 1994.
33. Gupta, R. C. Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo. Proc. Natl. Acad. Sci. USA, 81: 6943-6947, 1984.
34. Izzotti, A., Balansky, R. M., Coscia, N., Scatolini, L., D'Agostini, F., and De Flora, S. Chemoprevention of smoke-related DNA adduct formation in rat lung and heart. Carcinogenesis (Lond.), 13: 2187-2190, 1992.
35. Izzotti, A., Balansky, R. M., D'Agostini, F., Bennicelli, C., Myers, S. R., Grubbs, C. J., Lubet, R. A., Kelloff, G. J., and De Flora, S. Modulation of biomarkers by chemopreventive agents in smoke-exposed rats. Cancer Res., 61: 2472-2479, 2001.
36. Izzotti, A., D'Agostini, F., Bagnasco, M., Scatolini, L., Rovida, A., Balansky, R. M., Cesarone, C. F., and De Flora, S. Chemoprevention of carcinogen-DNA adducts and chronic degenerative diseases. Cancer Res., 54 (Suppl.): 1994s-1998s, 1994.
37. Izzotti, A., Bagnasco, M., D'Agostini, F., Cartiglia, C., Lubet, R. A., Kelloff, G. J., and De Flora, S. Formation and persistence of nucleotide alterations in rats exposed whole-body to environmental cigarette smoke. Carcinogenesis (Lond.), 20: 1499-1505, 1999.
38. Balansky, R., D'Agostini, F., and De Flora, S. Induction, persistence and modulation of cytogenetic alterations in cells of smoke-exposed mice. Carcinogenesis (Lond.). 20: 1491-1497, 1999.
39. Balansky, R. M. Effects of cigarette smoke and disulfiram on tumorigenicity and clastogenicity of ethyl carbamate in mice. Cancer Lett., 94: 91-95, 1995.
40. Rehm, S., Ward J. M., and Sass, B. Tumours of the lungs. In: V. S. Turusov, and U. Mohr (eds.), Pathology of Tumours in Laboratory Animals, Vol. II: Tumours of the Mouse, IARC Scientific Publications No. 111, pp. 325-355. Lyon, France: IARC, 1994.
41. Krishna, T. S., Kong, X. P., Gary, S., Burgers, P. M., and Kuriyan, J. Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell, 79: 1233-1243, 1994.
42. Umar, A., Buermeyer, A. B., Simon, J. A., Thomas, D. C., Clark, A. B., Liskay, R. M., and Kunkel, T. A. Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. Cell, 87: 65-73, 1996.
43. Nichols, A. F., and Sancar, A. Purification of PCNA as a nucleotide excision repair protein. Nucleic Acids Res., 20: 2441-2446, 1992.
44. Khuri, F. R., Lee, J. S., Lippman, S. M., Lee, J. J., Kalapurakal, S., Yu, R., Ro, J. Y., Morice, R. C. Hong, W. K., and Hittelman, W. N. Modulation of proliferating cell nuclear antigen in the bronchial epithelium of smokers. Cancer Epidemiol. Biomark. Prev., 10: 311-318, 2001.
45. Randerath, K., Putman, K. L., Oesterbyrg, N. N., Johnson, S. A., Morgan, D. G., and Finch, C. E. Age dependent increase of DNA adducts (I-compounds) in human and rat brain DNA. Mutat. Res., 295: 11-18, 1993.
46. Carmichael, P. L., Mills, J. J., Campbell, M., Basu, M., and Caldwell, J. Mechanisms of hormonal carcinogenesis in p53+/- hemizygous knockout mouse: studies with diethylstilbestrol. Toxicol. Pathol., 29(Suppl.): 155-160, 2001.
47. De Flora, S., Izzotti, A., Randerath, K., Randerath, E., Bartsch, H., Nair, J., Balansky, R., van Schooten, F. J., Degan, P., Fronza, G., Walsh, D., and Lewtas, J. DNA adducts in chronic degenerative diseases. Pathogenetic relevance and implications in preventive medicine. Mutat. Res., 366: 197-238, 1996.
48. Gaubatz, J. W. Postlabeling analysis of indigenous aromatic DNA adducts in mouse myocardium during aging. Arch. Gerontol. Geriatr., 8: 47-54, 1989.
49. Sarkar, S., Jülicher, K. P., Burger, M. S., Della Valle, V., Larsen, K.-J., Yeager, T. R., Grossman, T. B., Nickells, R. W., Protzel, C., Jarrard, D. F., and Reznikoff, C. A. Different combinations of genetic/epigenetic alterations inactivate the p53 and pRb pathways in invasive human bladder cancers. Cancer Res., 60: 3862-3871, 2000.
50. De Flora, S., Balansky, R., Gasparini, L., and Camoirano, A. Bacterial mutagenicity of cigarette smoke and its interaction with ethanol. Mutagenesis, 10: 47-52, 1995.