Epigenetic properties of the diarrhetic marine toxin okadaic acid: Inhibition of the gap junctional intercellular communication in a human intestine epithelial cell line

Archives of Toxicology

Volumn 77, Issue 11, 2003, Pages 657-662

  Traoré, Adama ^a   Baudrimont, Isabelle ^a   Dano, Sebastien ^b   Sanni, Ambaliou ^c   Larondelle, Yvan ^d   Schneider, Yves Jacques ^d   Creppy, Edmond Ekue ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b UNIVERSITÉ NANGUI ABROGOUA   (Côte d’Ivoire)

^c Faculty of Sciences and Technology   (Benin)

^d UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Connexin 43 mRNA; Gap junction inhibition; Intestinal Caco 2 cells; Okadaic acid

Indexed keywords

CLASTOGEN; CONNEXIN 43; GAP JUNCTION PROTEIN; MARINE TOXIN; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; RNA;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL LINE; CELL STRAIN CACO 2; CONTROLLED STUDY; CYTOSKELETON; DIARRHEA; DINOFLAGELLATE; GAP JUNCTION; GENETIC TRANSCRIPTION; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INTESTINE EPITHELIUM; INTRACELLULAR TRANSPORT; PHYTOPLANKTON; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SHELLFISH; TUMOR GROWTH;

CACO-2 CELLS; CARCINOGENS; CELL COMMUNICATION; CELL LINE; CELL SURVIVAL; CONNEXIN 43; DNA, COMPLEMENTARY; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GAP JUNCTIONS; HUMANS; INTESTINES; MUTAGENS; OKADAIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

DINOPHYCEAE;

EID: 0345603098     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-003-0460-0     Document Type: Article

References (42)

1. Amzil Z, Pouchus YF, Le Boterff J, Roussakis C, Verbist JF, Marcaillou-Lebaut C, Masselin P (1992) Short-time cytotoxicity of mussel extracts: a new bioassay for okadaic acid detection. Toxicon 30:1419-1425
2. Baker TK, Kwiatkowski AP, Madhukar BV, Klaunig JE (1995) Inhibition of gap junctional intercellular communication by 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) in rat hepatocytes. Carcinogenesis 16:2321-2326
3. Berven G, Seatre F, Halvorsen K, Seglen PO (2001) Effects of diarrhetic shellfish toxin, okadaic acid, on cytoskeletal element, viability and functionality of rat liver and intestinal cells. Toxicon 39:349-362
4. Beyer EC (1993) Gap junctions. Int Rev Cytol 137:1-37
5. Boe R, Gjertsen BT, Vintermyr OK, Houge G, Lanotte M, Doskeland SO (1991) The protein phosphatase inhibitor okadaic acid induced morphological changes typical of apoptosis in mammalian cell. Exp Cell Res 195:237-246
6. Budunova IV, Carbajal S, Slaga TJ (1996) Effect of divers tumor promoters on the expression of gap-junctional proteins connexin (Cx) 26, Cx-31. 1 and Cx-43 in SENCAR mouse epidermis. Mol Carcinog 15:202-214
7. Cesen-Cummings K, Fernstrom MJ, Malkinson AM, Ruch RJ (1998) Frequent reduction of gap junctional intercellular communication and connexin 43 expression in human and mouse lung carcinoma cells. Carcinogenesis 19:61-67
8. Ciminiello P, Fattorusso E, Forino M, Magno S, Poletti R, Viviani R (1999) Isolation of 45-hydroxyyessotoxin from mussels of the Adriatic sea. Toxicon 37:689-693
9. Cordier S, Monfort C, Miossec L, Richardson S, Belin C (2000) Ecological analysis of digestive cancer mortality related to contamination by diarrhetic shellfish poisoning toxins along the coasts of France. Environ Res 84:145-150
10. Fialkow L, Chan CK, Grinstein S, Downey GP (1993) Regulation of tyrosine phosphorylation in neutrophils by the NADPH oxidase. Role of reactive oxygen intermediates. J Biol Chem 268:17131
11. Fiorentini C, Matarrese P, Fattorossi A, Donelli G (1996) Okadaic acid induces changes in the organisation of F-actin in intestinal cells. Toxicon 34:937-945
12. Fujiki H, Suganuma M (1999) Unique features of the okadaic acid activity class of tumor promoters. J Cancer Res Clin Oncol 125:150-155
13. Guzman M, Castro J (1991) Okadaic acid stimulates carnitine palmitoyltransferase I activity and palmitate oxidation in isolated rat hepatocytes. FEBS Lett 291:105-108
14. IARC (1999) Overall evaluations of carcinogenicity to humans, IARC monographs (vol 1-73). IARC Scientific Publication, Lyon
15. Kenne K, Fransson-Steen R, Honkasalo S, Warngard L (1994) Two inhibitors of gap junctional intercellular communication, TPA and endosulfan: different effects on phosphorylation of connexin 43 in the rat liver epithelial cell line, IAR 20. Carcinogenesis 15:1161-1165
16. Klaunig JE, Ruch RJ (1990) Role of inhibition of intercellular communication in carcinogenesis. Lab Invest 62:135-146
17. Kojima T, Mitaka T, Mizuguchi T, Mochizuki Y (1996) Effects of oxygen radical scavengers on connexins 32 and 26 expression in primary cultures adult rat hepatocytes. Carcinogenesis 17:537-544
18. Kumar NM, Gilula NB (1996) The gap junction communication channel. Cell 84:381-388
19. Krutovskikh VA, Mesnil M, Mazzoleni G, Yamasaki H (1995) Inhibition of rat liver gap junction intercellular communication by tumor-promoting agents in vivo. Association with aberrant localization of connexin proteins. Lab Invest 72:571-577
20. Lerga A, Richard C, Delgrado MD, Canelles M, Frade P, Cuadrado MA, Leon J (1999) Apoptosis and mitotic arrest are two independent effects of the protein phosphatases inhibitor okadaic acid in K562 leukemia cells. Biochem Biophys Res Commun 24:256-264
21. Loktionova SA, Kabakov AE (1998) Protein phosphatase inhibitors and heat preconditioning prevent Hsp27 dephosphorylation, F-actin disruption and deterioration of morphology in ATP-depleted endothelial cells. FEBS Lett 433:294-300
22. Lozano Y, Taitz A, Petrzzelli GJ, Djordjevic A, Young MR (1996) Prostaglandin E2-protein kinase A signaling and protein phosphatases-1 and 2A regulate human head and neck squamous cell carcinoma motility, adherence, and cytoskeletal organisation. Prostanglandins 51:35-48
23. Matias WG, Traoré A, Creppy EE (1999a) Variations in the distribution of okadaic acid in organs biological fluids of mice related to diarrhoetic syndrome. Hum Exp Toxicol 18:345-350
24. Matias WG, Traoré A, Bonini M, Creppy EE (1999b) Oxygen reactive radicals production in cell culture by okadaic acid and their implication in protein synthesis inhibition. Hum Exp Toxicol 18:634-639
25. Matias WG, Creppy EE (1998) 5-Methyldeoxycytosine as a biological marker of DNA damage induced by okadaic acid in Vero cells. Environ Toxic Water Quality 13:83-87
26. Matias WG, Bonini M, Creppy EE (1996) Inhibition of protein synthesis in a cell free system and Vero cells by okadaic acid, a diarrhetic shellfish toxin. J Toxicol Environ Health 48:101-109
27. Okada T, Narai A, Matsunaga S, Fusetani N, Shimizu M (2000) Assessment of the marine toxins by monitoring the integrity of human intestinal Caco-2 cell monolayers. Toxicol In Vitro 14:219-226
28. Ren P, Mehta PP, Ruch RJ (1998) Inhibition of gap junctional intercellular communication by tumor promoters in connexin 43 and connexin 32-expressing liver cells: cell specificity and role of protein kinase C. Carcinogenesis 19:169-175
29. Ruch R (1994) The role of gap junctional intercellular communication in neoplasia. Ann Clin Lab Sci 24:216-231
30. Ruch RJ, Cesen-Cummings K, Malkinson AM (1998) Role of gap junctions in lung neoplasia. Exp Lung Res 24:523-539
31. Saez JC, Martinez AD, Branes MC, Gonzalez HE (1998) Regulation of gap junctions protein phosphorylation. Braz J Med Biol Res 31:593-600
32. Sai K, Kanno J, Hasegawa R, Trosko JE, Inoue T (2000) Prevention of gap junctional communication by green tea in the liver of mice fed pentachlorophenol. Carcinogenesis 12:1671-1676
33. Temme A, Traub O, Willecke K (1998) Downregulation of connexin 32 protein and gap-junction intercellular communication by cytokine-mediated acute-phase response in immortalized mouse hepatocytes. Cell Tissue Res 294:345-350
34. Traoré A, Bonini M, Dano DS, Creppy EE (1999a) Synergistic effects of some metals contaminating mussels on the cytotoxicity of the marine toxin okadaic acid. Arch Toxicol 73:289-295
35. Traoré A, Maeve L, Sanni A, Dano DS, Creppy, EE (1999b) Induction of apoptosis in human colonic epithelial cells (Caco-2) by okadaic acid (abstract of XXXVIIth European Congress of Toxicology EUROTOX 99 Oslo, June 27-30) (P202). Toxicol Lett 99 [Suppl 1]:73
36. Traoré A, Ambaliou S, Dano SD, Creppy EE (2000) Combined effects of okadaic acid and cadmium on lipid peroxidation and DNA bases modifications (m5dC and 8-(OH)-dG) in Caco-2 cells. Arch Toxicol 74:79-84
37. Trosko JE, Goodman JI (1994) Intercellular communication may facilitate apoptosis: implications for tumor promotion. Mol Carcinog 11:8-12
38. Trosko JE, Ruch RJ (1998) Cell-cell communication in carcinogenesis. Front Biosci 3:208-236
39. Turk PW, Laayoun A, Smith SS, Weitzman SA (1995) DNA adduct 8-hydroxy-2́-deoxyguanosine (8-hydroxyguanine) affects function of human DNA methyltransferase. Carcinogenesis 16:1253-1255
40. Upham BL, Kang KS, Cho HY, Trosko JE (1997) Hydrogen peroxide inhibits gap junctional intercellular communication in glutathion sufficient but not glutathion deficient cells. Carcinogenesis 18:37-42
41. Wachsman JT (1997) DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis. Mutat Res 375:1-8
42. Yamasaki H (1995) Non-genetic mechanisms of carcinogenesis: studies of cell transformation and gap junctional intercellular communication. Toxicol Lett 77:545-561