메뉴 건너뛰기




Volumn 50, Issue 54, 2003, Pages 1756-1760

Reduced p16 Expression Correlates with Lymphatic Invasion in Colorectal Cancers

Author keywords

Adenoma; Carcinoma in adenoma; Colorectal cancer; Hyperplastic polyp; Immunohistochemistry; p16; Prognosis

Indexed keywords

PROTEIN P16;

EID: 0345393069     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (35)

References (24)
  • 1
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993; 366:704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 2
    • 0028275733 scopus 로고
    • Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
    • Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA: Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 1994; 368:753-756.
    • (1994) Nature , vol.368 , pp. 753-756
    • Nobori, T.1    Miura, K.2    Wu, D.J.3    Lois, A.4    Takabayashi, K.5    Carson, D.A.6
  • 5
    • 0035835486 scopus 로고    scopus 로고
    • Mutations, methylation and expression of CDKN2a/p16 gene in colorectal cancer and normal colonic mucosa
    • Trzeciak L, Hennig E, Kolodziejski J, Nowacki M, Ostrowski J: Mutations, methylation and expression of CDKN2a/p16 gene in colorectal cancer and normal colonic mucosa. Cancer Lett 2001; 163:17-23.
    • (2001) Cancer Lett , vol.163 , pp. 17-23
    • Trzeciak, L.1    Hennig, E.2    Kolodziejski, J.3    Nowacki, M.4    Ostrowski, J.5
  • 6
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman JG, Merlo A, Mao L, Lapidus RG, Issa JP, Davidson NE, Sidransky D, Baylin SB: Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 1995; 55:4525-4530.
    • (1995) Cancer Res , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3    Lapidus, R.G.4    Issa, J.P.5    Davidson, N.E.6    Sidransky, D.7    Baylin, S.B.8
  • 7
    • 0028875205 scopus 로고
    • Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
    • Gonzalez-Zulueta M, Bender CM, Yang AS, Nguyen T, Beart RW, Van Tornout JM, Jones PA: Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 1995; 55:4531-4535.
    • (1995) Cancer Res , vol.55 , pp. 4531-4535
    • Gonzalez-Zulueta, M.1    Bender, C.M.2    Yang, A.S.3    Nguyen, T.4    Beart, R.W.5    Van Tornout, J.M.6    Jones, P.A.7
  • 8
    • 0036210281 scopus 로고    scopus 로고
    • p16 inactivation by methylation of the CDKN2A promoter occurs early during neoplastic progression in Barrett's esophagus
    • Bian YS, Osterheld MC, Fontolliet C, Bosman FT, Benhattar J, Biankin AV: p16 inactivation by methylation of the CDKN2A promoter occurs early during neoplastic progression in Barrett's esophagus. Gastroenterology 2002; 122:1113-1121.
    • (2002) Gastroenterology , vol.122 , pp. 1113-1121
    • Bian, Y.S.1    Osterheld, M.C.2    Fontolliet, C.3    Bosman, F.T.4    Benhattar, J.5    Biankin, A.V.6
  • 9
    • 0034662110 scopus 로고    scopus 로고
    • Methylation of specific CpG sites in the promoter region could significantly down-regulate p16(INK4a) expression in gastric adenocarcinoma
    • Song SH, Jong HS, Choi HH, Kang SH, Ryu MH, Kim NK, Kim WH, Bang YJ: Methylation of specific CpG sites in the promoter region could significantly down-regulate p16(INK4a) expression in gastric adenocarcinoma. Int J Cancer 2000; 87:236-240.
    • (2000) Int J Cancer , vol.87 , pp. 236-240
    • Song, S.H.1    Jong, H.S.2    Choi, H.H.3    Kang, S.H.4    Ryu, M.H.5    Kim, N.K.6    Kim, W.H.7    Bang, Y.J.8
  • 10
    • 0032924622 scopus 로고    scopus 로고
    • p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma
    • Matsuda Y, Ichida T, Matsuzawa J, Sugimura K, Asakura H: p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma. Gastroenterology 1999; 116:394-400.
    • (1999) Gastroenterology , vol.116 , pp. 394-400
    • Matsuda, Y.1    Ichida, T.2    Matsuzawa, J.3    Sugimura, K.4    Asakura, H.5
  • 11
    • 0031659626 scopus 로고    scopus 로고
    • Advantages of immunostaining over DNA analysis using PCR amplification to detect p53 abnormality in long-term formalin-fixed tissues of human colorectal carcinomas
    • Matsubayashi H, Watanabe H, Nishikura K, Ajioka Y, Maejima T, Kijima H, Saitoh T: Advantages of immunostaining over DNA analysis using PCR amplification to detect p53 abnormality in long-term formalin-fixed tissues of human colorectal carcinomas. J Gastroenterol 1998; 33:662-669.
    • (1998) J Gastroenterol , vol.33 , pp. 662-669
    • Matsubayashi, H.1    Watanabe, H.2    Nishikura, K.3    Ajioka, Y.4    Maejima, T.5    Kijima, H.6    Saitoh, T.7
  • 12
    • 0033778763 scopus 로고    scopus 로고
    • p16(INK4a) expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation
    • Dai CY, Furth EE, Mick R, Koh J, Takayama T, Niitsu Y, Enders GH: p16(INK4a) expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation. Gastroenterology 2000; 119:929-942.
    • (2000) Gastroenterology , vol.119 , pp. 929-942
    • Dai, C.Y.1    Furth, E.E.2    Mick, R.3    Koh, J.4    Takayama, T.5    Niitsu, Y.6    Enders, G.H.7
  • 13
    • 0032549041 scopus 로고    scopus 로고
    • p16/MTS1 inactivation in ovarian carcinomas: High frequency of reduced protein expression associated with hypermethylation or mutation in endometrioid and mucinous tumors
    • Milde-Langosch K, Ocon E, Becker G, Loning T: p16/MTS1 inactivation in ovarian carcinomas: high frequency of reduced protein expression associated with hypermethylation or mutation in endometrioid and mucinous tumors. Int J Cancer 1998; 79:61-65.
    • (1998) Int J Cancer , vol.79 , pp. 61-65
    • Milde-Langosch, K.1    Ocon, E.2    Becker, G.3    Loning, T.4
  • 15
    • 0031426989 scopus 로고    scopus 로고
    • Altered p16/MTS1/CDKN2 and cyclin D1/PRAD-1 gene expression is associated with the prognosis of squamous cell carcinoma of the esophagus
    • Takeuchi H, Ozawa S, Ando N, Shih CH, Koyanagi K, Ueda M, Kitajima M: Altered p16/MTS1/CDKN2 and cyclin D1/PRAD-1 gene expression is associated with the prognosis of squamous cell carcinoma of the esophagus. Clin Cancer Res 1997; 3:2229-2236.
    • (1997) Clin Cancer Res , vol.3 , pp. 2229-2236
    • Takeuchi, H.1    Ozawa, S.2    Ando, N.3    Shih, C.H.4    Koyanagi, K.5    Ueda, M.6    Kitajima, M.7
  • 17
    • 0034103810 scopus 로고    scopus 로고
    • Loss of nuclear p16 protein expression correlates with increased tumor cell proliferation (Ki-67) and poor prognosis in patients with vertical growth phase melanoma
    • Straume O, Sviland L, Akslen LA: Loss of nuclear p16 protein expression correlates with increased tumor cell proliferation (Ki-67) and poor prognosis in patients with vertical growth phase melanoma. Clin Cancer Res 2000; 6:1845-1853.
    • (2000) Clin Cancer Res , vol.6 , pp. 1845-1853
    • Straume, O.1    Sviland, L.2    Akslen, L.A.3
  • 19
    • 0033638229 scopus 로고    scopus 로고
    • Human colorectal cancers with an intact p16/cyclin D1/pRb pathway have up-regulated p16 expression and decreased proliferation in small invasive tumor clusters
    • Palmqvist R, Rutegard JN, Bozoky B, Landberg G, Stenling R: Human colorectal cancers with an intact p16/cyclin D1/pRb pathway have up-regulated p16 expression and decreased proliferation in small invasive tumor clusters. Am J Pathol 2000; 157:1947-1953.
    • (2000) Am J Pathol , vol.157 , pp. 1947-1953
    • Palmqvist, R.1    Rutegard, J.N.2    Bozoky, B.3    Landberg, G.4    Stenling, R.5
  • 20
    • 0030610586 scopus 로고    scopus 로고
    • Loss of expression of the p16INK4/CDKN2 gene in cutaneous malignant melanoma correlates with tumor cell proliferation and invasive stage
    • Talve L, Sauroja I, Collan Y, Punnonen K, Ekfors T: Loss of expression of the p16INK4/CDKN2 gene in cutaneous malignant melanoma correlates with tumor cell proliferation and invasive stage. Int J Cancer 1997; 74:255-259.
    • (1997) Int J Cancer , vol.74 , pp. 255-259
    • Talve, L.1    Sauroja, I.2    Collan, Y.3    Punnonen, K.4    Ekfors, T.5
  • 21
    • 0032948380 scopus 로고    scopus 로고
    • Overexpression of the cyclin-dependent kinase inhibitor p16 is associated with tumor recurrence in human prostate cancer
    • Lee CT, Capodieci P, Osman I, Fazzari M, Ferrara J, Scher HI, Cordon-Cardo C: Overexpression of the cyclin-dependent kinase inhibitor p16 is associated with tumor recurrence in human prostate cancer. Clin Cancer Res 1999; 5:977-983.
    • (1999) Clin Cancer Res , vol.5 , pp. 977-983
    • Lee, C.T.1    Capodieci, P.2    Osman, I.3    Fazzari, M.4    Ferrara, J.5    Scher, H.I.6    Cordon-Cardo, C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.