Human colorectal cancers with an intact p16/cyclin D1/pRb pathway have up-regulated p16 expression and decreased proliferation in small invasive tumor clusters

American Journal of Pathology

Volumn 157, Issue 6, 2000, Pages 1947-1953

  Palmqvist, Richard ^a   Rutegard, Jörgen N ^a,b   Bozoky, Bela ^a   Landberg, Göran ^c   Stenling, Roger ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b Örnsköldsviks Hospital   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; GENE PRODUCT; PROTEIN P16; RETINOBLASTOMA PROTEIN;

ARTICLE; CANCER INVASION; CELL COMPARTMENTALIZATION; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL TRANSFORMATION; CLUSTER ANALYSIS; COLORECTAL CANCER; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; METHYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; STROMA CELL; TUMOR GROWTH;

EID: 0033638229     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64833-X     Document Type: Article

References (27)

1. The grading of rectal cancer: Historical perspectives and a multivariate analysis of 447 cases
2. Character of the invasive margin in colorectal cancer: Does it improve prognostic information of Dukes' staging?
3. Prognostic significance of p27(Kip1) expression in colorectal cancer: A clinico-pathological characterisation
4. Factors influencing the estimates of proliferative labelling indices in rectal cancer
5. Systematic heterogeneity and prognostic significance of cell proliferation in colorectal cancer
6. Ki67 labelling index in gastric carcinomas: An immunohistochemical study using double staining for the evaluation of the proliferative activity of diffuse-type carcinomas
7. Cyclins, CDKs and cancer
8. Cancer cell cycles
9. Cyclins and cell cycle checkpoints
10. Inhibitors of mammalian G1 cyclin-dependent kinases
11. Lack of nuclear RB protein staining in G0/middle G1 cells: Correlation to changes in total RB protein level
12. The p16/cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis
13. Expression of cyclin D1 and the retinoblastoma protein in colorectal cancer
14. Activation but not inactivation of the MTS1 gene is associated with primary colorectal carcinomas
15. A comparison of the genetic pathways involved in the pathogenesis of three types of colorectal cancer
16. Association between CpG island methylation and microsatellite instability in colorectal cancer
17. p53 gene point mutations in relation to p53 nuclear protein accumulation in colorectal cancers
18. Sampling efficiency and biological variation in stereology
19. Comparison of proliferative activities and metastases between two subtypes classified at the deeply infiltrating sites of colorectal moderately differentiated adenocarcinomas
20. Extracellular matrix proteins inhibit proliferation, upregulate migration and induce morphological changes in human glioma cell lines
21. Glioma heterogeneity in vitro: The significance of growth factors and gangliosides
22. Tissue inhibitors of metalloproteinases (TIMP) in invasion and proliferation
23. Expressions of cell cycle regulators in human colorectal cancer cell lines
24. Orthotopic implantation of human colon carcinomas into nude mice provides a valuable model for the biology and therapy of metastasis
25. Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front
26. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
27. p16INK4 mediates contact-inhibition of growth