No regression of renal AL amyloid in monoclonal gammopathy after successful autologous blood stem cell transplantation and significant clinical improvement

Nephrology Dialysis Transplantation

Volumn 18, Issue 12, 2003, Pages 2644-2647

  Zeier, Martin ^a   Perz, Jolanta ^a   Linke, Reinhold P ^b   Donini, Ugo ^c   Waldherr, Rüdiger ^d   Andrassy, Konrad ^a   Ho, Anthony D ^a   Goldschmidt, Hartmut ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c Divisione di Nefrologia   (Italy)

^d Institute for Clinical Pathology   (Germany)

Author keywords

AL amyloidosis; Autologous stem cell transplantation; Nephrotic syndrome; Quantification of amyloid

Indexed keywords

AMYLOID; CORTICOSTEROID DERIVATIVE; DOXORUBICIN; IFOSFAMIDE; IMMUNOGLOBULIN A; MELPHALAN; MONOCLONAL ANTIBODY; VINCRISTINE;

ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; BONE MARROW BIOPSY; BRAIN DISEASE; CASE REPORT; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOHISTOCHEMISTRY; KIDNEY AMYLOIDOSIS; KIDNEY BIOPSY; MALE; MONOCLONAL IMMUNOGLOBULINEMIA; PLASMA CELL DYSCRASIA; PRIORITY JOURNAL; REMISSION; URINARY EXCRETION;

AMYLOID; AMYLOIDOSIS; ANTINEOPLASTIC AGENTS, ALKYLATING; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; KIDNEY DISEASES; MALE; MELPHALAN; MIDDLE AGED; PARAPROTEINEMIAS; REMISSION INDUCTION; TRANSPLANTATION, AUTOLOGOUS;

EID: 0345328195     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/gfg436     Document Type: Article

References (18)

1. Linke RP. Highly sensitive diagnosis of amyloid and various amyloid syndromes using Congo red fluorescence. Virchows Arch 2000; 436: 439-448
2. Kyle RA, Gertz MA, Greipp PR, Witzig TE, Lust JA, Lacy MQ. A trial of three regimens of primary amyloidosis alone, melphalan, prednisone, and melphalan, prednisone, and colchicine. N Engl J Med 1997; 336: 1202-1207
3. Gertz MA, Kyle RA, O'Fallon WM. Dialysis support of patients with primary systemic amyloidosis. A study of 211 patients. Arch Intern Med 1992; 152: 2245-2250
4. Kyle RA, Gertz MA. Primary systemic amyloidosis: clinical and laboratory features in 474 cases. Semin Hematol 199; 32: 45-59
5. Skinner M, Anderson J, Simms R, Falk R, Wang M, Lilley C. Treatment of 100 patients with primary amyloidosis: a randomized trial of melphalan, prednisone, and colchicine versus colchicine only. Am J Med 1996; 100: 290-298
6. Dember LM, Sanchorawala V, Seldin DC et al. Effect of dose intensive intravenous melphalan and autologous blood stem-cell transplantation on AL-amyloidosis-associated renal disease. Ann Intern Med 2001; 134: 746-753
7. Falk RH, Comenzo RL, Skinner M. The systemic amyloidoses. N Engl J Med 1997; 337: 898-903
8. Russel WJ, Cardelli J, Harris E, Baier RJ, Herrera GA. Monoclonal light chain-mesangial cell interactions: early signalling events and subsequent pathologic effects. Lab Invest 2001; 81: 689-703
9. Ogg CS, Cameron JS, Williams DG, Turner DR. Progression and course of primary amyloidosis of the kidney. Clin Nephrol 1981; 15: 9-13
10. Richter GW. The resorption of amyloid under experimental conditions. Am J Pathol 1954; 30: 239-251
11. Lowenstein J, Gallo G. Remission of the nephrotic syndrome in renal amyloidosis. N Engl J Med 1970; 282: 128-132
12. van Buren M, Hené RJ, Verdonck LF, Verzijbergen FJ, Lokhorst HM. Clinical remission after syngeneic bone marrow transplantation in a patient with AL amyloidosis. Ann Intern Med 1995; 122: 508-510
13. Gertz MA, Lacy MQ, Dispenzieri A et al. Stem cell transplantation for the management of primary systemic amyloidosis. Am J Med 2002; 113: 549-555
14. Donini U, Casanova S, Zucchelli P, Poli C, Carboni G, Linke RP. Computer-aided quantitation of amyloid in renal biopsies. In Natvig JB, Forte O, Husby G et al., eds. Amyloid and Amyloidosis. Kluwer Academic Publishers, Dordrecht, The Netherlands; 1991: 793-796
15. Sanchorawala V, Wright DG, Seldin DC et al. An overview of the use of high-dose melphalan with autologous stem cell transplantation for the treatment of AL amyloidosis. Bone Marrow Transplant 2001; 28: 637-642
16. Droz D, Noel LH, Barbanel CI, Leibowitch J. Glomerulonéphrite à dépôts intercapillaires d'IgA lors d'une gammopathie monoclonale bénigne. Nouv Presse Med 1981; 10: 3652-3653
17. Mandreoli M, Casanova S, Vianelli N, Pasquali S, Zucchelli P. Remission of nephrotic syndrome due to AA amyloidosis: an initiation of glomerular repair after surgical resection of localized Castleman's syndrome. Nephron 2002; 90: 336-340
18. Yan SD, Zhu H, Zhu A et al. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis. Nat Med 2000; 6: 643-651