Role for Retinoblastoma Protein Family Members in UV-enhanced Expression from the Human Cytomegalovirus Immediate Early Promoter

Photochemistry and Photobiology

Volumn 77, Issue 6, 2003, Pages 621-627

  Francist, Murray A ^a,b   Rainbow, Andrew J ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; IMMEDIATE EARLY PROTEIN; PROTEIN P 48; PROTEIN P107; PROTEIN P53; PROTEIN SUBUNIT; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FIBROBLAST; GENE CONSTRUCT; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMEDIATE EARLY GENE; MOUSE; MULTIGENE FAMILY; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; RADIATION ATTENUATION; REPORTER GENE; ULTRAVIOLET RADIATION; UPREGULATION; WART VIRUS; XERODERMA PIGMENTOSUM;

ANIMALS; CYTOMEGALOVIRUS; FIBROBLASTS; GENE DELETION; GENE EXPRESSION REGULATION, VIRAL; GENES, IMMEDIATE-EARLY; GENES, REPORTER; HUMANS; MICE; NUCLEAR PROTEINS; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PROMOTER REGIONS (GENETICS); RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P107; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS; XERODERMA PIGMENTOSUM;

ANIMALIA; CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5; HUMAN PAPILLOMAVIRUS TYPES; MURINAE; PAPILLOMAVIRUS; SIMIAE; SIMIAN VIRUS 40;

EID: 0345328120     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/0031-8655(2003)077<0621:RFRPFM>2.0.CO;2     Document Type: Article

References (75)

1. Sachsenmaier, C., A. Radler-Pohl, R. Zinck, A. Nordheim, P. Herrlich and H. J. Rahmsdoff (1994) Involvement of growth factor receptors in the mammalian UVC response. Cell 78, 963-972.
2. Bender, K., C. Blattner, A. Knebel, M. Iordanov, P. Herrlich and H. J. Rahmsdorf (1997) UV-induced signal transduction. J. Photochem. Phorobiol. B: Biol. 37, 1-17.
3. Liu, Y., M. Gorospe, C. Yang and N. J. Holbrook (1995) Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation. J. Biol. Chem. 270, 8377-8380.
4. Hirsch, D. D. and P. J. Stork (1997) Mitogen-activated protein kinase phosphatases inactivate stress-activated protein kinase pathways in vivo. J. Biol. Chem. 272, 4568-4575.
5. Schorpp, M., U. Mallick, H. J. Rahmsdorf and P. Herrlich (1984) UV-induced extracellular factor from human fibroblasts communicates the UV response to nonirradiated cells. Cell 37, 861-868.
6. Stein, B., H. J. Rahmsdorf, A. Steffen, M. Litfin and P. Herrlich (1989) UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein. Mol. Cell. Biol. 9, 5169-5181.
7. Blattner, C., K. Bender, P, Herrlich and H. J. Rahmsdorf (1998) Photoproducts in transcriptionally active DNA induce signal transduction to the delayed U.V.-responsive genes for collagenase and metallothionein. Oncogene 16, 2827-2834.
8. Venema, J., L. H. Mullenders, A. T. Natarajan, A. A. van Zeeland and L. V. Mayne (1990) The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA. Proc. Natl. Acad. Sci. USA 87, 4707-4711.
9. van Hoffen, A., A. T. Natarajan, L. V. Mayne, A. A. van Zeeland, L. H. Mullenders and J. Venema (1993) Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells. Nucleic Acids Res. 21, 5890-5895.
10. Stein, B., M. Kramer, H. J. Rahmsdorf, H. Ponta and P. Herrlich (1989) UV-induced transcription from the human immunodeficiency virus type I (HIV-1) long terminal repeat and UV-induced secretion of an extracellular factor that induces HIV-1 transcription in nonirradiated cells. J. Virol. 63, 4540-4544.
11. Herrlich, P., H. Ponta and H. J. Rahmsdorf (1992) DNA damage-induced gene expression: signal transduction and relation to growth factor signaling. Rev. Physiol. Biochem. Pharmacol. 119, 187-223.
12. Kramer, M., C. Sachsenmaier, P. Herrlich and H. J. Rahmsdorf (1993) UV irradiation-induced interleukin-1 and basic fibroblast growth factor synthesis and release mediate part of the UV response. J. Biol. Chem. 268, 6734-6741.
13. Francis, M. A. and A. J. Rainbow (2000) UV-enhanced expression of a reporter gene is induced at lower UV fluences in transcription-coupled repair deficient compared to normal human fibroblasts, and is absent in SV40-transformed counterparts. Photochem. Photobiol. 72, 554-561.
14. Mietz, J. A., T. Unger, J. M. Huibregtse and P. M. Howley (1992) The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein. EMBO J. 11, 5013-5020.
15. Segawa, K., A. Minowa, K. Sugasawa, T. Takano and F. Hanaoka (1993) Abrogation of p53-mediated transactivation by SV40 large T antigen. Oncogene 8, 543-548.
16. DeCaprio, J. A., J. W. Ludlow, J. Figge, J. Y. Shew, C. M. Huang, W. H. Lee, E. Marsilio, E. Paucha and D. M. Livingston (1988) SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54, 275-283.
17. Ludlow, J. W. (1993) Interactions between SV40 large-tumor antigen and the growth suppressor proteins pRB and p53. FASEB J. 7, 866-871.
18. Stubdal, H., J. Zalvide and J. A. DeCaprio (1996) Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107. J. Virol. 70, 2781-2788.
19. Wolf, D. A., H. Hermeking, T. Albert, T. Herzinger, P. Kind and D. Eick (1995) A complex between E2F and the pRb-related protein p130 is specifically targeted by the simian virus 40 large T antigen during cell transformation. Oncogene 10, 2067-2078.
20. Ueda, M., N. U. Ahmed, T. Bito, T. Nagano and M. Ichihashi (1996) The expression of retinoblastoma protein in epidermis is induced by ultraviolet B exposure. Br. J. Dermatol. 135, 406-411.
21. Yamaizumi, M. and T. Sugano (1994) U.V.-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle. Oncogene 9, 2775-2784.
22. Lakin, N. D. and S. P. Jackson (1999) Regulation of p53 in response to DNA damage. Oncogene 18, 7644-7655.
23. el-Deiry, W. S. (1998) Regulation of p53 downstream genes. Semin. Cancer Biol. 8, 345-357.
24. Mayol, X. and X. Grana (1997) pRb, p107 and p130 as transcriptional regulators: role in cell growth and differentiation. Prog. Cell Cycle Res. 3, 157-169.
25. McKay, B. C., M. A. Francis and A. J. Rainbow (1997) Wildtype p53 is required for heat shock and ultraviolet light enhanced repair of a UV-damaged reporter gene. Carcinogenesis 18, 245-249.
26. Khandjian, E. W. and S. Tremblay (1992) Phosphorylation of the retinoblastoma protein is modulated in mouse kidney cells infected with polyomavirus. Oncogene 7, 909-917.
27. Dyson, N., K. Buchkovich, P. Whyte and E. Harlow (1989) The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell 58, 249-255.
28. Mor, O., M. Read and M. Fried (1997) p53 in polyoma virus transformed Ref52 cells. Oncogene 15, 3113-3119.
29. Werness, B. A., A. J. Levine and P. M. Howley (1990) Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248, 76-79.
30. Scheffner, M., B. A. Werness, J. M. Huibregtse, A. J. Levine and P. M. Howley (1990) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63, 1129-1136.
31. Dyson, N., P. M. Howley, K. Munger and E. Harlow (1989) The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243, 934-937.
32. Davies, R., R. Hicks, T. Crook, J. Morris and K. Vousden (1993) Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation. J. Virol. 67, 2521-2528.
33. Seedorf, K., T. Oltersdorf, G. Krammer and W. Rowekamp (1987) Identification of early proteins of the human papilloma viruses type 16 (HPV 16) and type 18 (HPV 18) in cervical carcinoma cells. EMBO J. 6, 139-144.
34. Berezutskaya, E., B. Yu, A. Morozov, P. Raychaudhuri and S. Bagchi (1997) Differential regulation of the pocket domains of the retinoblastoma family proteins by the HPV16 E7 oncoprotein. Cell Growth Differ. 8, 1277-1286.
35. Pedley, J., E. M. Ablett, A. Pettit, J. Meyer, I. S. Dunn, R. A. Sturm and P. G. Parsons (1996) Inhibition of retinoblastoma protein translation by UVB in human melanocytic cells and reduced cell cycle arrest following repeated irradiation. Oncogene 13, 1335-1342.
36. McKay, B. C., C. Becerril and M. Ljungman (2001) P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts. Oncogene 20, 6805-6808.
37. LeCouter, J. E., B. Kablar, W. R. Hardy, C. Ying, L. A. Megency, L. L. May and M. A. Rudnicki (1998) Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the pRb-related p107 gene. Mol. Cell. Biol. 18, 7455-7465.
38. Morsy, M. A., E. L. Alford, A. Bett, F. L. Graham and T. Caskey (1993) Efficient adenoviral-mediated ornithine transcarboxylase expression in deficient mouse and human hepatocytes. J. Clin. Investig. 92, 1580-1586.
39. Graham, F. L. and L. Prevec (1991) Manipulation of adenovirus vectors. In Gene Transfer and Expression Protocols, Vol. VII (Edited by E. J. Murray), pp. 109-128. The Humana Press Inc., Clifton, NJ.
40. McKay, B. C., C. Winrow and A. J. Rainbow (1997) Capacity of UV-irradiated human fibroblasts to support adenovirus DNA synthesis correlates with transcription-coupled repair and is reduced in SV40-transformed cells and cells expressing mutant p53. Photochem. Photobiol. 66, 659-664.
41. Hwang, B. J., J. M. Ford, P. C. Hanawalt and G. Chu (1999) Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair. Proc. Natl. Acad. Sci. USA 96, 424-428.
42. Nichols, A. F., T. Itoh, J. A. Graham, W. Liu, M. Yamaizumi and S. Linn (2000) Human damage-specific DNA-binding protein p48. Characterization of XPE mutations and regulation following UV irradiation. J. Biol. Chem. 275, 21422-21428.
43. Sellers, W. R. and W. G. Kaelin (1996) RB as a modulator of transcription. Biochim. Biophys. Acta 1288, M1-M5.
44. Hofferer, M., C. Wirbelauer, B. Humar and W. Krek (1999) Increased levels of E2F-1-dependent DNA binding activity after UV- or gamma-irradiation. Nucleic Acids Res. 27, 491-495.
45. Hayes, S., P. Shiyanov, X. Chen and P. Raychaudhuri (1998) DDB, a putative DNA repair protein, can function as a transcriptional partner of E2F1. Mol. Cell. Biol. 18, 240-249.
46. Shiyanov, P., S. A. Hayes, M. Donepudi, A. F. Nichols, S. Linn, B. L. Slagle and P. Raychaudhuri (1999) The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription. Mol. Cell. Biol. 19, 4935-4943.
47. Mulligan, G. and T. Jacks (1998) The retinoblastoma gene family: cousins with overlapping interests. Trends Genet. 14, 223-229.
48. Rohde, M., P. Warthoe, T. Gjetting, J. Lukas, J. Bartek and M. Strauss (1996) The retinoblastoma protein modulates expression of genes coding for diverse classes of proteins including components of the extracellular matrix. Oncogene 12, 2393-2401.
49. Cao, L., B. Faha, M. Dembski, L. H. Tsai, E. Harlow and N. Dyson (1992) Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. Nature 355, 176-179.
50. Flemington, E. K., S. H. Speck and W. G. Kaelin Jr. (1993) E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product. Proc. Natl. Acad. Sci. USA 90, 6914-6918.
51. Helin, K., E. Harlow and A. Fattaey (1993) Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol. Cell. Biol. 13, 6501-6508.
52. Kim, S. J., U. S. Onwuta, Y. I. Lee, R. Li, M. R. Botchan and P. D. Robbins (1992) The retinoblastoma gene product regulates Sp1-mediated transcription. Mol. Cell. Biol. 12, 2455-2463.
53. Chen, L. I., T. Nishinaka, K. Kwan, I. Kitabayashi, K. Yokoyama, Y. H. Fu, S. Grunwald and R. Chiu (1994) The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator. Mol. Cell. Biol. 14, 4380-4389.
54. Kim, S. J., S, Wagner, F. Liu, O. R. Ma, P. D. Robbins and M. R. Green (1992) Retinoblastoma gene product activates expression of the human TGF-beta 2 gene through transcription factor ATF-2. Nature 358, 331-334.
55. Gong, Q., Z. Huang and W. D. Wicks (1995) Interaction of retinoblastoma gene product with transcription factors ATFa and ATF2. Arch. Biochem. Biophys. 319, 445-450.
56. Nishitani, J., T. Nishinaka, C. H. Cheng, W. Rong, K. K. Yokoyama and R. Chiu (1999) Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-1 binding site. J. Biol. Chem. 274, 5454-5461.
57. Tamami, M., P. F. Lindholm and J. N. Brady (1996) The retinoblastoma gene product (Rb) induces binding of a conformationally inactive nuclear factor-kappaB. J. Biol. Chem. 271, 24551-24556.
58. Radler-Pohl, A., C. Sachsenmaier, S. Gebel, H. P. Auer, J. T. Bruder, U. Rapp, P. Angel, H. J. Rahmsdorf and P. Herrlich (1993) UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase. EMBO J. 12, 1005-1012.
59. Dong, Z., C. Huang, W. Y. Ma, B. Malewicz, W. J. Baumann and Z. Kiss (1998) Increased synthesis of phosphocholine is required for UV-induced AP-1 activation. Oncogene 17, 1845-1853.
60. Gupta, S., D. Campbell, B. Derijard and R. J. Davis (1995) Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267, 389-393.
61. van Dam, H., D. Wilhelm, I. Herr, A. Steffen, P. Herrlich and P. Angel (1995) ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 14, 1798-1811.
62. Iordanov, M., K. Bender, T. Ade, W. Schmid, C. Sachsenmaier, K. Engel, M. Gaestel, H. J. Rahmsdoff and P. Herrlich (1997) CREB is activated by UVC through a p38/HOG-1-dependent protein kinase. EMBO J. 16, 1009-1022.
63. Devary, Y., C. Rosette, J. A. DiDonato and M. Karin (1993) NF-kappa B activation by ultraviolet light not dependent on a nuclear signal. Science 261, 1442-1445.
64. Bender, K., M. Gottlicher, S. Whiteside, H. J. Rahmsdorf and P. Herrlich (1998) Sequential DNA damage-independent and -dependent activation of NF-kappaB by UV. EMBO J. 17, 5170-5181.
65. Legrand-Poels, S., S. Schoonbroodt, J. Y. Matroule and J. Piette (1998) NF-kappa B: an important transcription factor in photobiology. J. Photochem. Photobiol. B: Biol. 45, 1-8.
66. Haapajarvi, T., L. Kivinen, A. Heiskanen, C. des Bordes, M. B. Datto, X. F. Wang and M. Laiho (1999) UV radiation is a transcriptional inducer of p21 (Cip1/Waf1) cyclin-kinase inhibitor in ap53-independent manner. Exp. Cell Res. 248, 272-279.
67. Hibi, M., A. Lin, T. Smeal, A. Minden and M. Karin (1993) Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7, 2135-2148.
68. Derijard, B., M. Hibi, I. H. Wu, T. Barrett, B. Su, T. Deng, M. Karin and R. J. Davis (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025-1037.
69. Adler, V., S. Y. Fuchs, J. Kim, A. Kraft, M. P. King, J. Pelling and Z. Ronai (1995) jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells. Cell Growth Differ. 6, 1437-1446.
70. el-Deiry, W. S., S. E. Kern, J. A. Pietenpol, K. W. Kinzler and B. Vogelstein (1992) Definition of a consensus binding site for p53. Nat. Genet. 1, 45-49.
71. Ouellette, M. M., J. Chen, W. E. Wright and J. W. Shay (1992) Complexes containing the retinoblastoma gene product recognize different DNA motifs related to the E2F binding site. Oncogene 7, 1075-1081.
72. Yang, Y. M. and Z. Ronai (1995) Ultraviolet light-responsive element (TGACAACA)-binding proteins in cells of xeroderma pigmentosum patients. Mol. Carcinog. 14, 111-117.
73. Chang, Y. N., K. T. Jeang, C. J. Chiou, Y. J. Chan, M. Pizzomo and G. S. Hayward (1993) Identification of a large bent DNA domain and binding sites for serum response factor adjacent to the NFI repeat cluster and enhancer region in the major IE94 promoter from simian cytomegalovirus. J. Virol. 67, 516-529.
74. Sambucetti, L. C., J. M. Cherrington, G. W. Wilkinson and E. S. Mocarski (1989) NF-kappa B activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation. EMBO J. 8, 4251-4258.
75. Zhang, X. Y., N. M. Inamdar, P. C. Supakar, K. Wu, K. C. Ehrlich and M. Ehrlich (1991) Three MDBP sites in the immediate-early enhancer-promoter region of human cytomegalovirus. Virology 182, 865-869.