UV-enhanced expression of a reporter gene is induced at lower UV fluences in transcription-coupled repair deficient compared to normal human fibroblasts, and is absent in SV40-transformed counterparts

Photochemistry and Photobiology

Volumn 72, Issue 4, 2000, Pages 554-561

  Francis, Murray A ^a   Rainbow, Andrew J ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ARTICLE; CANCER CELL; CELL TRANSFORMATION; COCKAYNE SYNDROME; CONTROLLED STUDY; CYTOMEGALOVIRUS; EXCISION REPAIR; FAMILIAL CANCER; FIBROBLAST; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENE MUTATION; HELA CELL; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMEDIATE EARLY GENE; PROMOTER REGION; REPORTER GENE; SIMIAN VIRUS 40; ULTRAVIOLET IRRADIATION; XERODERMA PIGMENTOSUM;

ANIMALS; CELL LINE; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, VIRAL; CYTOMEGALOVIRUS; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; FIBROBLASTS; GENE EXPRESSION; GENES, REPORTER; HELA CELLS; HUMANS; MICE; SIMIAN VIRUS 40; TRANSCRIPTION, GENETIC; ULTRAVIOLET RAYS;

CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5; MOUSE CYTOMEGALOVIRUS 1; MURINAE; SIMIAE; SIMIAN VIRUS 40;

EID: 0034309782     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/0031-8655(2000)072<0554:UEEOAR>2.0.CO;2     Document Type: Article

References (50)

1. Mayne, L. V. and A. R. Lehmann (1982) Failure of RNA synthesis to recover after UV irradiation: an early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum. Cancer Res. 42, 1473-1478.
2. Bender, K., C. Blattner, A. Knebel, M. Iordanov, P. Herrlich and H. J. Rahmsdorf (1997) UV-induced signal transduction. J. Photochem. Photobiol. B: Biol. 37, 1-17.
3. Herrlich, P., C. Sachsenmaier, A. Radler-Pohl, S. Gebel, C. Blattner and H. J. Rahmsdorf (1994) The mammalian UV response: mechanism of DNA damage induced gene expression. Adv. Enzyme Regul. 34, 381-395.
4. Miskin, R. and R. Ben-Ishai (1981) Induction of plasminogen activator by UV light in normal and xeroderma pigmentosum fibroblasts. Proc. Natl. Acad. Sci. USA 78, 6236-6240.
5. Blattner, C., K. Bender, P. Herrlich and H. J. Rahmsdorf (1998) Photoproducts in transcriptionally active DNA induce signal transduction to the delayed U.V.-responsive genes for collagenase and metallothionein. Oncogene 16, 2827-2834.
6. Mellon, I., V. A. Bohr, C. A. Smith and P. C. Hanawalt (1986) Preferential DNA repair of an active gene in human cells. Proc. Natl. Acad. Sci. USA 83, 8878-8882.
7. Mellon, I., G. Spivak and P. C. Hanawalt (1987) Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene. Cell 51, 241-249.
8. Friedberg, E. C., G. C. Walker and W. Siede (1995) DNA repair and Mutagenesis. ASM Press, Washington, DC.
9. Vermeulen, W., J. de Boer, E. Citterio, A. J. van Gool, G. T. van der Horst, N. G. Jaspers, W. L. de Laat, A. M. Sijbers, P. J. van der Spek, K. Sugasawa, G. Weeda, G. S. Winkler, D. Bootsma, J. M. Egly and J. H. Hoeijmakers (1997) Mammalian nucleotide excision repair and syndromes. Biochem. Soc. Trans. 25, 309-315.
10. Venema, J., A. van Hoffen, A. T. Natarajan, A. A. van Zeeland and L. H. Mullenders (1990) The residual repair capacity of xeroderma pigmentosum complementation group C fibroblasts is highly specific for transcriptionally active DNA. Nucleic-Acids Res. 18, 443-448.
11. Venema, J., A. van Hoffen, V. Karcagi, A. T. Natarajan, A. A. van Zeeland and L. H. Mullenders (1991) Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes. Mol. Cell. Biol. 11, 4128-4134.
12. Venema, J., L. H. Mullenders, A. T. Natarajan, A. A. van Zeeland and L. V. Mayne (1990) The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA. Proc. Natl. Acad. Sci. USA 87, 4707-4711.
13. van Hoffen, A., A. T. Natarajan, L. V. Mayne, A. A. van Zeeland, L. H. Mullenders and J. Venema (1993) Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells. Nucleic-Acids Res. 21, 5890-5895.
14. Bruening, W., B. Giasson, W. Mushynski and H. D. Durham (1998) Activation of stress-activated MAP protein kinases up-regulates expression of transgenes driven by the cytomegalovirus immediate/early promoter. Nucleic-Acids Res. 26, 486-489.
15. Tang, D. C., R. S. Jennelle, Z. Shi, R. I. Garver Jr., D. P. Carbone, F. Loya, C. H. Chang and D. T. Curiel (1997) Overexpression of adenovirus-encoded transgenes from the cytomegalovirus immediate early promoter in irradiated tumor cells. Hum. Gene Ther. 8, 2117-2124.
16. Adler, V., S. Y. Fuchs, J. Kim, A. Kraft, M. P. King, J. Pelling and Z. Ronai (1995) jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells. Cell Growth Differ. 6, 1437-1446.
17. Addison, C. L., M. Hitt, D. Kunsken and F. L. Graham (1997) Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors. J. Gen. Virol. 78, 1653-1661.
18. Morsy, M. A., E. L. Alford, A. Bett, F. L. Graham and T. Caskey (1993) Efficient adenoviral-mediated ornithine transcarboxylase expression in deficient mouse and human hepatocytes. J. Clin. Investig. 92, 1580-1586.
19. McKay, B. C., M. Ljungman and A. J. Rainbow (1999) Potential roles for p53 in nucleotide excision repair. Carcinogenesis 20, 1389-1396.
20. Lakin, N. D. and S. P. Jackson (1999) Regulation of p53 in response to DNA damage. Oncogene 18, 7644-7655.
21. el-Deiry, W. S. (1998) Regulation of p53 downstream genes. Semin. Cancer Biol. 8, 345-357.
22. Mayol, X. and X. Grana (1997) pRb, p107 and p130 as transcriptional regulators: role in cell growth and differentiation. Prog. Cell Cycle Res. 3, 157-169.
23. Seedorf, K., T. Oltersdorf, G. Krammer and W. Rowekamp (1987) Identification of early proteins of the human papilloma viruses type 16 (HPV 16) and type 18 (HPV 18) in cervical carcinoma cells. EMBO J. 6, 139-144.
24. Mietz, J. A., T. Unger, J. M. Huibregtse and P. M. Howley (1992) The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein. EMBO J. 11, 5013-5020.
25. Scheffner, M., B. A. Werness, J. M. Huibregtse, A. J. Levine and P. M. Howley (1990) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63, 1129-1136.
26. Segawa, K., A. Minowa, K. Sugasawa, T. Takano and F. Hanaoka (1993) Abrogation of p53-mediated transactivation by SV40 large T antigen. Oncogene 8, 543-548.
27. Malkin, D., F. P. Li, L. C. Strong, J. F. Fraumeni Jr., C. E. Nelson, D. H. Kim, J. Kassel, M. A. Gryka, F. Z. Bischoff, M. A. Tainsky and S. H. Friend (1990) Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250, 1233-1238.
28. Yin, Y., M. A. Tainsky, F. Z. Bischoff, L. C. Strong and G. M. Wahl (1992) Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70, 937-948.
29. Graham, F. L. and L. Prevec (1991) Manipulation of adenovirus vectors. In Gene Transfer and Expression Protocols, Vol. 7 (Edited by E. J. Murray), pp. 109-128. The Humana Press, Clifton.
30. McKay, B. C., C. Winrow and A. J. Rainbow (1997) Capacity of UV-irradiated human fibroblasts to support adenovirus DNA synthesis correlates with transcription-coupled repair and is reduced in SV40-transformed cells and cells expressing mutant p53. Photochem. Photobiol. 66, 659-664.
31. Bennett, C. B. and A. J. Rainbow (1988) Enhanced reactivation and mutagenesis of UV-irradiated adenovirus in normal human fibroblasts. Mutagenesis 3, 157-164.
32. McKay, B. C., M. A. Francis and A. J. Rainbow (1997) Wild-type p53 is required for heat shock and ultraviolet light enhanced repair of a UV-damaged reporter gene. Carcinogenesis 18, 245-249.
33. Lusky, M., M. Christ, K. Rittner, A. Dieterle, D. Dreyer, B. Mourot, H. Schultz, F. Stoeckel, A. Pavirani and M. Mehtali (1998) In vitro and in vivo biology of recombinant adenovirus vectors with E1, E1/E2A, or E1/E4 deleted. J. Virol. 72, 2022-2032.
34. Miller, C. S., R. J. Jacob and D. G. Hiser (1993) UV-enhanced replication of herpes simplex virus in DNA-repair competent and deficient fibroblasts. Oral Surg. Oral Med. Oral Pathol. 75, 602-609.
35. Naumovski, L., G. Chu, P. Berg and E. C. Friedberg (1985) RAD3 gene of Saccharomyces cerevisiae: nucleotide sequence of wild-type and mutant alleles, transcript mapping, and aspects of gene regulation. Mol. Cell. Biol. 5, 17-26.
36. Robinson, G. W., C. M. Nicolet, D. Kalainov and E. C. Friedberg (1986) A yeast excision-repair gene is inducible by DNA damaging agents. Proc. Natl. Acad. Sci. USA 83, 1842-1846.
37. Reynolds, P., L. Prakash and S. Prakash (1987) Nucleotide sequence and functional analysis of the RAD1 gene of Saccharomyces cerevisiae. Mol. Cell. Biol. 7, 1012-1020.
38. Cole, G. M., D. Schild, S. T. Lovett and R. K. Mortimer (1987) Regulation of RAD54- and RAD52-lacZ gene fusions in Saccharomyces cerevisiae in response to DNA damage. Mol. Cell. Biol. 7, 1078-1084.
39. Zider, A., B. Mashhour, P. Fergelot, G. Grimber, M. Vernet, U. Hazan, D. Couton, P. Briand and C. Cavard (1993) Dispensable role of the NF-kappa B sites in the UV-induction of the HIV-1 LTR in transgenic mice. Nucleic-Acids Res. 21, 79-86.
40. Kline, J. N., G. M. Hunninghake, B. He, M. M. Monick and G. W. Hunninghake (1998) Synergistic activation of the human cytomegalovirus major immediate early promoter by prostaglandin E2 and cytokines. Exp. Lung Res. 24, 3-14.
41. Olive, D. M., W. al-Mulla, M. Simsek, S. Zarban and W. al-Nakib (1990) The human cytomegalovirus immediate early enhancer-promoter is responsive to activation by the adenovirus-5 13S E1A gene. Arch. Virol. 112, 67-80.
42. Wilkinson, G. W. and A. Akrigg (1992) Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector. Nucleic-Acids Res. 20, 2233-2239.
43. Stamminger, T., H. Fickenscher and B. Fleckenstein (1990) Cell type-specific induction of the major immediate early enhancer of human cytomegalovirus by cyclic AMP. J. Gen. Virol. 71, 105-113.
44. McKay, B. C. and M. Ljungman (1999) Role for p53 in the recovery of transcription and protection against apoptosis induced by ultraviolet light. Neoplasia 1, 276-284.
45. McKay, B. C., M. Ljungman and A. J. Rainbow (1998) Persistent DNA damage induced by ultraviolet light inhibits p21waf1 and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis. Oncogene 17, 545-555.
46. Ljungman, M. and F. Zhang (1996) Blockage of RNA polymerase as a possible trigger for u.v. light-induced apoptosis. Oncogene 13, 823-831.
47. Rainbow, A. J. (1989) Defective repair of UV-damaged DNA in human tumor and SV40-transforrned human cells but not in adenovirus-transformed human cells. Carcinogenesis 10, 1073-1077.
48. Squires, S., R. T. Johnson and A. R. Collins (1982) Initial rates of DNA incision in UV-irradiated human cells: differences between normal, xeroderma pigmentosum and tumour cells. Mutation Res. 95, 389-404.
49. Berezutskaya, E., B. Yu, A. Morozov, P. Raychaudhuri and S. Bagchi (1997) Differential regulation of the pocket domains of the retinoblastoma family proteins by the HPV16 E7 oncoprotein. Cell Growth Differ. 8, 1277-1286.
50. Pedley, J., E. M. Ablett, A. Pettit, J. Meyer, I. S. Dunn, R. A. Sturm and P. G. Parsons (1996) Inhibition of retinoblastoma protein translation by UVB in human melanocytic cells and reduced cell cycle arrest following repeated irradiation. Oncogene 13, 1335-1342.