Neurosteroid consumption has anxiolytic effects in mice

Pharmacology Biochemistry and Behavior

Volumn 76, Issue 3-4, 2003, Pages 451-462

  Finn, Deborah A ^a,b   Roberts, Amanda J ^b,c   Long, Season ^b   Tanchuck, Michelle ^b   Phillips, Tamara J ^a,b  

^a PORTLAND VA MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Allopregnanolone; C57BL 6J; DBA 2J; Elevated plus maze; Inbred strains; Neuroactive steroid; Preference drinking; Pregnanolone hemisuccinate

Indexed keywords

ANXIOLYTIC AGENT; NEUROSTEROID; TAP WATER;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRINKING; DRUG USE; LIGHT DARK CYCLE; MALE; MAZE TEST; MEDICAL ASSESSMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANQUILIZING ACTIVITY;

ANIMALIA;

EID: 0345276531     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2003.09.004     Document Type: Article

References (53)

1. Alomary A.A., Fitzgerald R.L., Purdy R.H. Neurosteroid analysis. Int. Rev. Neurobiol. 46:2001;97-115.
2. Ator N.A., Grant K.A., Purdy R.H., Paul S.M., Griffiths R.R. Drug discrimination analysis of endogenous neuroactive steroids in rats. Eur. J. Pharmacol. 241:1993;237-243.
3. 2 inhalation. Eur. J. Pharmacol. 261:1994;317-320.
4. A receptor function after acute stress. Neuroendocrinology. 63:1996;166-172.
5. Belelli D., Lan N.C., Gee K.W. Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex. Neurosci. Biobehav. Rev. 14:1990;315-322.
6. Belknap J.K., Coleman R.R., Foster K. Alcohol consumption and sensory threshold differences between C57BL/6J and DBA/2J mice. Physiol. Psychol. 6:1978;71-74.
7. Belknap J.K., Crabbe J.C., Young E.R. Voluntary consumption of ethanol in 15 inbred mouse strains. Psychopharmacology. 112:1993;503-510.
8. Boehm S.L. II, Reed C.L., McKinnon C.S., Phillips T.J. Shared genes influence sensitivity to the effects of ethanol on locomotor activity and anxiety-like behaviors, and the stress axis. Psychopharmacology. 161:2002;54-63.
9. Bowen C.A., Purdy R.H., Grant K.A. Ethanol-like discriminative stimulus effects of endogenous neuroactive steroids: effect of ethanol training dose and dosing procedure. J. Pharmacol. Exp. Ther. 289:1999;405-411.
10. Concas A., Mostallino M.C., Porcu P., Follesa P., Barbaccia M.L., Trabucchi M.et al. Role of brain allopregnanolone in the plasticity of gamma-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery. Proc. Natl. Acad. Sci. 95:1998;13284-13289.
11. Cunningham C.L., Niehus D.R., Malott D.H., Prather L.K. Genetic differences in the rewarding and activating effects of morphine and ethanol. Psychopharmacology. 107:1992;385-393.
12. Dudek B.C., Phillips T.J., Hahn M.E. Genetic analysis of the biphasic nature of the alcohol dose-response curve. Alcohol. Clin. Exp. Res. 15:1991;262-269.
13. Finn D.A., Gee K.W. The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid. J. Pharmacol. Exp. Ther. 271:1994;164-170.
14. Finn D.A., Phillips T.J., Okorn D.M., Chester J.A., Cunningham C.L. Rewarding effect of the neuroactive steroid 3α-hydroxy-5α-pregnan- 20-one in mice. Pharmacol. Biochem. Behav. 56:1997;261-264.
15. Finn D.A., Roberts A.J., Lotrich F., Gallaher E.J. Genetic differences in behavioral sensitivity to a neuroactive steroid. J. Pharmacol. Exp. Ther. 280:1997;820-828.
16. Gasior M., Carter R.B., Witkin J.M. Neuroactive steroids: potential therapeutic use in neurological and psychiatric disorders. Trends Pharmacol. Sci. 20:1999;107-112.
17. Gee K.W., Bolger M.B., Brinton R.E., Coirini H., McEwen B.S. Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action. J. Pharmacol. Exp. Ther. 246:1988;803-812.
18. Grahame N.J., Cunningham C.L. Intravenous ethanol self-administration in C57BL/6J and DBA/2J mice. Alcohol. Clin. Exp. Res. 21:1997;56-62.
19. Grant K.A. Animal models of the addiction process. Kranzler H.R. The pharmacology of alcohol abuse. Handbook of Experimental Pharmacology. vol. 114:1995;185-229 Springer-Verlag, Berlin.
20. Grant K.A., Azarov A., Shively C.A., Purdy R.H. Discriminative stimulus effects of ethanol and 3α-hydroxy-5α-pregnan-20-one in relation to menstrual cycle phase in cynomolgus monkeys (Macaca fascicularis). Psychopharmacology. 130:1997;59-68.
21. 2+ responses: structure activity studies. J. Pharmacol. Exp. Ther. 271:1994;677-682.
22. Janak P.H., Redfern J.E.M., Samson H.H. The reinforcing effects of ethanol are altered by the endogenous neurosteroid, allopregnanolone. Alcohol. Clin. Exp. Res. 22:1998;1106-1112.
23. A receptor function. Trends Pharmacol. Sci. 16:1995;295-303.
24. Lister R.G. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology. 92:1987;180-185.
25. McBride W.J., Li T.-K. Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Crit. Rev. Neurobiol. 12:1998;339-369.
26. McClearn G.E., Rodgers D.A. Differences in alcohol preference among inbred strains of mice. Q. J. Stud. Alcohol. 20:1959;691-695.
27. Morrow A.L., Suzdak P.D., Paul S.M. Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency. Eur. J. Pharmacol. 142:1987;483-485.
28. Morrow A.L., Pace J.R., Purdy R.H., Paul S.M. Characterization of steroid interactions with γ-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple recognition sites. Mol. Pharmacol. 37:1990;263-270.
29. Morrow A.L., VanDoren M.J., Fleming R., Penland S. Ethanol and neurosteroid interactions in the brain. Int. Rev. Neurobiol. 46:2001;349-377.
30. Palmer A.A., Miller M.N., McKinnon C.S., Phillips T.J. Sensitivity to the locomotor stimulant effects of ethanol and allopregnanolone shares common genetic influence. Behav. Neurosci. 116:2002;126-137.
31. Park-Chung M., Wu F.S., Farb D.H. 3α-hydroxy-5β-pregnan-20- one sulfate: a negative modulator at the NMDA receptor. Mol. Pharmacol. 46:1994;146-150.
32. A receptor function through distinct sites. Brain Res. 830:1999;72-87.
33. Paul S.M., Purdy R.H. Neuroactive steroids. FASEB J. 6:1992;2311-2322.
34. Phillips T.J., Crabbe J.C. Behavioral studies of genetic differences in alcohol action. Crabbe J.C., Harris R.A. The genetic basis of alcohol and drug actions. 1991;25-104 Plenum, New York.
35. Phillips T.J., Crabbe J.C., Metten P., Belknap J.K. Localization of genes affecting alcohol drinking in mice. Alcohol. Clin. Exp. Res. 18:1994;931-941.
36. Phillips T.J., Huson M., Gwiazdon C., Burkhart-Kasch S., Shen E.H. Effects of acute and repeated ethanol exposures on the locomotor activity of BXD recombinant inbred mice. Alcohol. Clin. Exp. Res. 19:1995;269-278.
37. Purdy R.H., Moore P.H. Jr., Rao N., Hagino N., Yamaguchi T., Schmidt P. et al. Radioimmunoassay of 3α-hydroxy-5α-pregnan-20-one in rat and human plasma. Steroids. 55:1990;290-296.
38. Rodgers R.J., Johnson N.J.T. Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety. Pharmacol. Biochem. Behav. 52:1995;297-303.
39. Rodgers R.J., Johnson N.J.T. Behaviorally selective effects of neuroactive steroids on plus-maze anxiety in mice. Pharmacol. Biochem. Behav. 59:1998;221-232.
40. Rowlett J.K., Winger G., Carter R.B., Wood P.L., Woods J.H., Woolverton W.L. Reinforcing and discriminative stimulus effects of the neuroactive steroids pregnanolone and Co 8-7071 in rhesus monkeys. Psychopharmacology. 145:1999;205-212.
41. Sadri-Vakili G., Johnson D.W., Janis G.C., Gibbs T.T., Pierce R.C., Farb D.H. Inhibition of NMDA-induced striatal dopamine release and behavioral activation by the neuroactive steroid 3α-hydroxy-5β-pregnan-20-one hemisuccinate. J. Neurochem. 86:2003;92-101.
42. Shelton K.L., Grant K.A. Discriminative stimulus effects of ethanol in C57BL/6J and DBA/2J inbred mice. Alcohol. Clin. Exp. Res. 26:2002;747-757.
43. Sinnott R.S., Mark G.P., Finn D.A. Reinforcing effects of the neurosteroid allopregnanolone in rats. Pharmacol. Biochem. Behav. 72:2002;923-929.
44. Sinnott R.S., Phillips T.J., Finn D.A. Alteration of voluntary ethanol and saccharin consumption by the neurosteroid allopregnanolone in mice. Psychopharmacology. 162:2002;438-447.
45. Trullas R., Skolnick P. Differences in fear motivated behaviors among inbred mouse strains. Psychopharmacology. 111:1993;323-331.
46. Uzunov D.P., Cooper T.B., Costa E., Guidotti A. Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography. Proc. Natl. Acad. Sci. 93:1996;12599-12604.
47. Vanover K.E. Discriminative stimulus effects of the endogenous neuroactive steroid pregnanolone. Eur. J. Pharmacol. 327:1997;97-101.
48. Vanover K.E. Effects of benzodiazepine receptor ligands and ethanol in rats trained to discriminate pregnanolone. Pharmacol. Biochem. Behav. 67:2000;483-487.
49. A receptor: differential interaction of benzodiazepines and neuroactive steroids with ethanol. Psychopharmacology. 141:1999;77-82.
50. Weaver C.E. Jr., Marek P., Park-Chung M., Tam S.W., Farb D.H. Neuroprotective activity of a new class of steroidal inhibitors of the N-methyl-D-aspartate receptor. Proc. Natl. Acad. Sci. 94:1997;10450-10454.
51. 2+ accumulation and cell death. J. Pharmacol. Exp. Ther. 293:2000;747-754.
52. Weiland S., Beluzzi J.D., Stein L., Lan N.C. Comparative behavioral characterization of the neuroactive steroids 3α-OH, 5α-pregnan-20- one and 3α-OH, 5β-pregnan-20-one in rodents. Psychopharmacology. 118:1995;65-71.
53. Wenger G.R. The role of control activity levels in the reported strain differences to the behavioral effects of drugs in mice. Pharmacol. Biochem. Behav. 32:1989;241-247.