Heme-Protein Active Site Models via Self-Assembly in Water

Organic Letters

Volumn 5, Issue 19, 2003, Pages 3367-3370

  Fiammengo, Roberto ^a   Wojciechowski, Kamil ^a,c   Crego Calama, Mercedes ^a   Timmerman, Peter ^a   Figoli, Alberto ^b   Wessling, Matthias ^b   Reinhoudt, David N ^a  

^a UNIVERSITY OF TWENTE   (Netherlands)

^b UNIVERSITY OF TWENTE   (Netherlands)

^c Analyt Biophysical Environ Chem   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYLIMIDAZOLE; ALKENE DERIVATIVE; CAFFEINE; CATION; COBALT; HEMOPROTEIN; LIGAND; OXYGEN; PICOLINE; PORPHYRIN; PYRIDINE DERIVATIVE; TETRASULFONATOCALIX[4]ARENE; UNCLASSIFIED DRUG; WATER; ZINC;

ARTICLE; CHEMICAL BINDING; CHEMICAL MODEL; ENCAPSULATION; PROTEIN ASSEMBLY; SOLUBILITY;

BINDING SITES; CAFFEINE; CALIXARENES; CALORIMETRY; COBALT; HEMEPROTEINS; IMIDAZOLES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PEPTIDES; PHENOLS; PORPHYRINS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; WATER; ZINC;

EID: 0345255242     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol030053w     Document Type: Article

References (26)

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18. -7 M), confirming nonaggregation of the porphyrin. Hydrophilic anions were chosen because anions such as borates and perchlorates were causing aggregation.
19. c to the porphyrin center can be better visualized in the molecular simulation structure (CHARMm 24.0) of assembly 1.2 (see Figure 3 in Supporting Information).
20. In contrast, 1a,b bearing single amino acid-based (short) chains do not show these interactions.
21. 1.2.
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