Pathology of difficult asthma

Paediatric Respiratory Reviews

Volumn 4, Issue 4, 2003, Pages 306-311

  Wenzel, Sally ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Asthma; Inflammation; Pathology; Phenotypes; Physiology; Remodelling

Indexed keywords

CORTICOSTEROID DERIVATIVE; CYTOKINE; GELATINASE B; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

ASTHMA; CHILD; CHILDHOOD DISEASE; CYTOKINE RELEASE; DISEASE SEVERITY; ENVIRONMENTAL FACTOR; EOSINOPHILIA; HEREDITY; HUMAN; INFLAMMATION; INFLAMMATORY INFILTRATE; LUNG PARENCHYMA; MAST CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

EID: 0345169967     PISSN: 15260542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1526-0542(03)00095-2     Document Type: Article

References (45)

1. Wenzel SE, Fahy JV, Irvin CG, Peters SP, Spector S, Szefler SJ. Proceedings of the ATS Workshop on Refractory Asthma - current understanding, recommendations and unanswered questions. Am J Respir Crit Care Med 2000; 162: 2341-2351.
2. Oswald H, Phelan PD, Lanigan A et al. Childhood asthma and lung function in mid-adult life. Pediatr Pulmonol 1997; 23: 14-20.
3. Ulrik CS, Lange P. Decline of lung function in adults with bronchial asthma. Am J Respir Crit Care Med 1994; 150: 629-634.
4. ten Brinke A, van Dissel JT, Sterk PJ, Zwinderman AH, Rabe KF, Bel EH. Persistent airflow limitation in adult-onset nonatopic asthma is associated with serologic evidence of Chlamydia pneumoniae infection. J Allergy Clin Immunol 2001; 107: 449-454.
5. Gibbs R, Miranda C, Wenzel S. Initial demographic information from an extensive data base of severe, steroid dependent asthmatics studied at National Jewish. Am J Respir Crit Care Med 2002; 165: A119.
6. Miranda T, Strand MS, Trudeau JB, Fisher SJ, Wenzel SE. Severe asthmatics (SA) with late onset disease (LOD) have greater eosinophilic inflammation, airway obstruction and are less steroid responsive than early onset disease (EOD). Am J Respir Crit Care Med 2003; 167: A856.
7. Woolcock AJ, Rebuck AS, Cade JF, Read J. Lung volume changes in asthma measured concurrently by two methods. Am Rev Respir Dis 1971; 104: 703-709.
8. Woolcock AJ, Read J. The static elastic properties in the lungs in asthma. Am Rev Respir Dis 1968; 98: 788-794.
9. Gelb AF, Zamel N. Unsuspected pseudophysiologic emphysema in chronic persistent asthma. Am J Respir Crit Care Med 2000; 162: 1778-1782.
10. Wenzel SE, Schwartz LB, Langmack EL et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999; 160: 1001-1008.
11. Chetta A, Foresi A, Donno MD, Bertorelli G, Pesci A, Olivieri D. Airway remodeling is a distinctive feature of asthma and is related to severity of asthma. Chest 1997; 111: 852-857.
12. Cho SH, Seo JY, Choi DC et al. Pathological changes according to the severity of asthma. Clin Exp Allergy 1996; 26: 1210-1219.
13. Chu HW, Trudeau JB, Balzar S, Wenzel S. Peripheral blood and airway tissue expression of transforming growth factor beta by neutrophils in asthmatic subjects and normal control subjects. J Allergy Clin Immunol 2000; 106: 1115-1123.
14. Chu HW, Balzar S, Westcott JY et al. Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition. Clin Exp Allergy 2002; 32: 1558-1565.
15. Wenzel SE, Szefler SJ, Leung DYM, Sloan SI, Rex MD, Martin RJ. Bronchoscopic evaluation of severe asthma: persistent inflammation associated with high dose glucocorticoids. Am J Respir Crit Care Med 1997; 156: 737-743.
16. Jatakanon A, Uasuf C, Maziak W, Lim S, Chung KF, Barnes PJ. Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med 1999; 160: 1532-1539.
17. Louis R, Lau LCK, Bron AO, Roldaan AC, Radermecker M, Djukanovi R. The relationship between airways inflammation and asthma severity. Am J Respir Crit Care Med 2000; 161: 9-16.
18. Jensen SP, Lynch DA, Brown KK, Wenzel SE, Newell JD. High-resolution CT features of severe asthma and bronchiolitis obliterans. Clin Radiology 2002; 57: 1078-1085.
19. Cox G. Glucocorticoid treatment inhibits apoptosis in human neutrophils. Separation of survival and activation outcomes. Am Assoc Immunol 1995; 154: 4719-4725.
20. Vaillant B, Chiaramonte MG, Cheever AW, Soloway PD, Wynn TA. Regulation of hepatic fibrosis and extracellular matrix genes by the response: new insight into the role of tissue inhibitors of matrix metalloproteinases. J Immunol 2001; 167: 7017-7026.
21. Wenzel SE, Balzar S, Cundall M, Chu HW. Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation and wound repair. J Allergy Clin Immunol 2003; 111: 1345-1352.
22. Green RH, Brightling CE, Woltmann G, Parker D, Wardlaw AJ, Pavord ID. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002; 57: 875-879.
23. Payne DN, Adcock IM, Wilson NM, Oates T, Scallan M, Bush A. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone [comment]. Am J Respir Crit Care Med 2001; 164: 1376-1381.
24. Kam JC, Szefler SJ, Surs W, Sher ER, Leung DY. Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. J Immunol 1993; 151: 3460-3466.
25. Lane SJ, Adcock IM, Richards D, Hawrylowicz C, Barnes PJ, Lee TH. Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes. J Clin Invest 1998; 102: 2156-2164.
26. Leung DY, Hamid Q, Vottero A et al. Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta. J Exp Med 1997; 186: 1567-1574.
27. Payne DN, Rogers AV, Adelroth E et al. Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med 2003; 167: 78-82.
28. Minshall EM, Hogg JC, Hamid QA. Cytokine mRNA expression in asthma is not restricted to the large airways. J Allergy Clin Immunol 1998; 101: 386-390.
29. Wenzel SE, Trudeau JB, Barnes S et al. TGF-beta and IL-13 synergistically increase eotaxin-I production in human airway fibroblasts. J Immunol 2002; 169: 4613-4619.
30. Wenzel S, Barnes S, Westcott J et al. TGF-Beta + IL-13 increases eotaxin in a cell and mediator specific manner associated with increases in procollagen. Am J Respir Crit Care Med 2002; 165: A730.
31. Takeyama K, Fahy JV, Nadel JA. Relationship of epidermal growth factor receptors to goblet cell production in human bronchi. Am J Respir Crit Care Med 2001; 163: 511-516.
32. Howat WJ, Holgate ST, Lackie PM. TGF-beta isoform release and activation during in vitro bronchial elpithelial wound repair. Am J Physiol Lung Cell Mol Physiol 2002; 282: L115-L123.
33. Chu HW, Balzar S, Tilstra JA, Wenzel SE. TGF-beta2 expression in bronchial epithelium is increased and associated with goblet cell metaplasia in asthma. Am J Respir Crit Care Med 2003; 167: A452.
34. James AL, Pare PD. Hogg JC. The mechanics of airway narrowing in asthma. Am Rev Respir Dis 1989; 139: 242-246.
35. Bousquet J, Lacoste J-Y, Chanez P, Vic P, Godard P, Francois-Bernard M. Bronchial elastic fibers in normal subjects and asthmatic patients. Am J Respir Crit Care Med 1996; 153: 1648-1654.
36. Mauad T, Xavier ACG, Saldiva PHN, Dolhnikoff M. Elastosis and fragmentation of fibers of the elastic system in fatal asthma. Am J Respir Crit Care Med 1999; 160: 968-975.
37. Vignola AM, Riccobono L, Mirabella A et al. Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am J Respir Crit Care Med 1998; 158: 1945-1950.
38. Lemjabbar H, Gosset P, Lamblin C et al. Contribution of 92 kDa gelatinase/type IV collagenase in bronchial inflammation during status asthmaticus. Am J Respir Crit Care Med 1999; 159: 1298-1307.
39. Carroll NG, Elliot J, Morton AR, James AL. The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis 1993; 147: 405-410.
40. Carroll NG, Mutavdzic S, James AL. Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J 2002; 19: 879-885.
41. Kraft M, Djukanovic R, Wilson S, Holgate ST, Martin RJ. Alveolar tissue inflammation in asthma. Am J Respir Crit Care Med 1996; 154: 1505-1510.
42. Balzar S, Wenzel SE, Chu HW. Transbronchial biopsy as a tool to evaluate small airways in asthma. Eur Respir J 2002; 20: 254-259.
43. Balzar S, Chu HW, Strand MS, Wenzel SE. Chymase-positive mast cells in distal airways of severe asthma: positive correlation with lung function. Am J Respir Crit Care Med 2003; 167: A703.
44. Wenzel SE, Chu HW. Transbronchial biopsy as a tool to evaluate small airways in asthma. Eur Respir J 2002; 20: 254-259.
45. Leach CL, Davidson PJ, Boudreau RJ. Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone. Eur Respir J 1998; 12: 1346-1353.