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Volumn 13, Issue 6, 2003, Pages 685-690

Neural mechanisms of reward-related motor learning

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE;

EID: 0345118165     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.conb.2003.10.013     Document Type: Review
Times cited : (225)

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    • Floresco S.B., Blaha C.D., Yang C.R., Phillips A.G. Modulation of hippocampal and amygdalar-evoked activity of nucleus accumbens neurons by dopamine: cellular mechanisms of input selection. J Neurosci. 21:2001;2851-2860 The authors combined extracellular single unit recordings of nucleus accumbens neurons with chronoamperometric measures of dopamine efflux. Potentiation of the hippocampal-evoked response was induced in accumbens cells by HFS of the fimbria. This dopamine D-1 dependent potentiation was associated with a transient increase in dopamine concentration in the accumbens. The subsequent release of dopamine after induction of this facilitation did not appear to play a role.
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    • A cellular mechanism of reward-related learning
    • This study showed that stimulation of the substantia nigra pars compacta, using stimuli that supported ICSS, led to potentiation of corticostriatal responses. The potentiation was mediated by dopamine D-1 receptors. Analysis of learning and synaptic plasticity in the same animals showed a significant relationship between the degree of potentiation and the time taken to learn ICSS behavior.
    • Reynolds J.N.J., Hyland B.I., Wickens J.R. A cellular mechanism of reward-related learning. Nature. 413:2001;67-70 This study showed that stimulation of the substantia nigra pars compacta, using stimuli that supported ICSS, led to potentiation of corticostriatal responses. The potentiation was mediated by dopamine D-1 receptors. Analysis of learning and synaptic plasticity in the same animals showed a significant relationship between the degree of potentiation and the time taken to learn ICSS behavior.
    • (2001) Nature , vol.413 , pp. 67-70
    • Reynolds, J.N.J.1    Hyland, B.I.2    Wickens, J.R.3
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    • Dopamine-dependent synaptic plasticity in the striatal cholinergic interneurons
    • This study demonstrates dopamine D1-receptor dependent synaptic plasticity in both monosynaptic excitatory and disynaptic inhibitory inputs to cholinergic interneurons. The excitatory inputs showed potentiation after high-frequency stimulation of corticostriatal and thalamostriatal afferents. The inhibitory inputs, thought to be from axon collaterals of spiny projection neurons, showed a decreased apparent failure rate. These changes may be relevant to the learning-related changes in reported in cholinergic interneurons.
    • Suzuki T., Miura M., Nishimura K., Aosaki T. Dopamine-dependent synaptic plasticity in the striatal cholinergic interneurons. J Neurosci. 21:2001;6492-6501 This study demonstrates dopamine D1-receptor dependent synaptic plasticity in both monosynaptic excitatory and disynaptic inhibitory inputs to cholinergic interneurons. The excitatory inputs showed potentiation after high-frequency stimulation of corticostriatal and thalamostriatal afferents. The inhibitory inputs, thought to be from axon collaterals of spiny projection neurons, showed a decreased apparent failure rate. These changes may be relevant to the learning-related changes in reported in cholinergic interneurons.
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    • Suzuki, T.1    Miura, M.2    Nishimura, K.3    Aosaki, T.4
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    • Inhibitory interactions between spiny projection neurons in the rat striatum
    • Tunstall M.J., Oorschot D.E., Kean A., Wickens J.R. Inhibitory interactions between spiny projection neurons in the rat striatum. J Neurophysiol. 88:2002;1263-1269.
    • (2002) J Neurophysiol , vol.88 , pp. 1263-1269
    • Tunstall, M.J.1    Oorschot, D.E.2    Kean, A.3    Wickens, J.R.4
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    • Dopamine regulation of synaptic plasticity in the neostriatum: A cellular model of reinforcement
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    • Wickens JR: Dopamine regulation of synaptic plasticity in the neostriatum: a cellular model of reinforcement. In Brain Dynamics and the Striatal Complex. Edited by Miller R, Wickens JR: Harwood Academic; 2000:65-76.
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    • Wickens, J.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.