Accumulation of apolipoprotein C-I-rich and cholesterol-rich VLDL remnants during exaggerated postprandial triglyceridemia in normolipidemic patients with coronary artery disease

Circulation

Volumn 101, Issue 3, 2000, Pages 227-230

  Björkegren, Johan ^a,d   Boquist, Susanna ^a,b   Samnegård, Ann ^c   Lundman, Pia ^c   Tornvall, Per ^b   Ericsson, Carl Göran ^c   Hamsten, Anders ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c DANDERYD HOSPITAL   (Sweden)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Atherosclerosis; Lipids; Lipoproteins; Myocardial infarction

Indexed keywords

APOLIPOPROTEIN C1; CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; HUMAN; HYPERTRIGLYCERIDEMIA; LIPID COMPOSITION; LIPID STORAGE; LIPOPROTEIN BLOOD LEVEL; MALE; PARTICLE SIZE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0343820043     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.101.3.227     Document Type: Article

References (11)

1. Karpe F. Postprandial lipid metabolism in relation to coronary heart disease. Proc Nutr Soc. 1997;56:671-678.
2. Björkegren J, Packard CJ, Hamsten A, Bedford D, Caslake M, Shepherd J, Foster L, Stewart P, Karpe F. Accumulation of large very low density lipoprotein in plasma during intravenous infusion of a chylomicron-like triglyceride emulsion reflects competition for a common lipolytic pathway. J Lipid Res. 1996;37:76-86.
3. Tornvall P, Båvenholm P, Landou C, deFaire U, Hamsten A. Relation of plasma levels and composition of apolipoprotein B-containing lipoproteins to angiographically defined coronary artery disease in young patients with myocardial infarction. Circulation. 1993;88:2180-2189.
4. Phillips NR, Waters D, Havel RJ. Plasma lipoproteins and progression of coronary artery disease evaluated by angiography and clinical events. Circulation. 1993;88:2762-2770.
5. Björkegren J, Hamsten A, Milne RW, Karpe F. Alterations of VLDL composition during alimentary lipemia. J Lipid Res. 1997;38:301-314.
6. Hodis HN, Mack WJ. Triglyceride-rich lipoproteins and progression of atherosclerosis. Eur. Heart J. 1998;19(suppl A):A40-A44.
7. Zilversmit DB. Atherogenesis: a postprandial phenomenon. Circulation. 1979;60:473-485.
8. Sehayek E, Eisenberg S. Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway. J Biol Chem. 1991;266:18259-18267.
9. Kowal RC, Herz J, Weisgraber KH, Mahley RW, Brown MS, Goldstein JL. Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J Biol Chem. 1990;265: 10771-10779.
10. Shachter NS, Ebara T, Ramakrishnan R, Steiner G, Breslow JL, Ginsberg HN, Smith JD. Combined hyperlipidemia in transgenic mice overexpressing human apolipoprotein CI. J Clin Invest. 1996;98:846-855.
11. Shaikh M, Wootton R, Nordestgaard BG, Baskerville P, Lumely JS, Ville AEL, Quiney J, Lewis B. Quantitative studies of transfer in vivo of low density, Sf 12-60, and Sf 60-400 lipoproteins between plasma and arterial intima in humans. Arterioscler Thromb. 1991;11:569-577.