Efficient synthesis of quinazolin-4-ones and axially chiral 2,2'-bis-quinazolin-4-ones by reaction of anthranilic acid derived nucleophiles with oxalic acid-bis(imidoyl)chlorides

Synlett

Volumn , Issue 7, 1999, Pages 1100-1102

  Wuckelt, Jörg ^a   Döring, Manfred ^a   Beckert, Rainer ^a   Langer, Peter ^b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Alkaloids; Atropic isomers; Cyclization reactions; Oxalic acid derivatives; Regioselectivity

Indexed keywords

ALKALOID DERIVATIVE; ANTHRANILIC ACID DERIVATIVE; CHLORIDE; HETEROCYCLIC COMPOUND; NARCOTIC AGENT; OXALIC ACID DERIVATIVE; QUINAZOLIN 4 ONE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; CYCLIZATION; DRUG SYNTHESIS; LYSIS; STEREOSPECIFICITY; STRUCTURE ANALYSIS;

EID: 0345085558     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1999-2760     Document Type: Article

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28. 2: C, 73.89%; H, 4.43%; N, 12.31%. Found: C, 74.16%; H, 4.65%; N, 12.07%. All new compounds gave satisfactory spectroscopic data and correct analytical and/ or high resolution mass data.
29. 8: C, 65.59%; H, 4.86%; N, 9.00%. Found: C, 65.89%; H, 4.71%; N, 9.21%.