Identification of oxidative degradates of the TRIS salt of a 5,6,7,8-tetrahydro-1,8-naphthyridine derivative by LC/MS/MS and NMR spectroscopy - Interactions between the active pharmaceutical ingredient and its counterion

Journal of Pharmaceutical and Biomedical Analysis

Volumn 33, Issue 5, 2003, Pages 999-1015

  Wu, Yunhui ^a   Hwang, Tsang Lin ^a   Algayer, Kimberly ^a   Xu, Wei ^a   Wang, Hong ^a   Procopio, Adam ^a   Debusi, Laura ^a   Yang, Chia Yi ^a   Matuszewska, Bozena ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Degradates; Dimerization; Drug counterion interaction; LC MS; NMR; Oxidation; Tandem mass spectrometry; Tetrahydronaphthyridine; TRIS salt

Indexed keywords

1,8 NAPHTHYRIDINE DERIVATIVE; 5,6,7,8 TETRAHYDRO 1,8 NAPHTHYRIDINE; AMIDE; MANNITOL; OXIDE; TROMETAMOL; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DIMERIZATION; DRUG DEGRADATION; DRUG FORMULATION; DRUG STRUCTURE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR INTERACTION; OXIDATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SAMPLING; STANDARDIZATION; TEMPERATURE;

EID: 0345059114     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(03)00423-0     Document Type: Article

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