Autocatalytic degradation and stability of obidoxime

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 1, 1999, Pages 9-14

  Rubnov, Shai ^a   Shats, Igor ^a   Levy, Daniel ^a   Amisar, Shai ^a   Schneider, Hava ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

OBIDOXIME;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG DEGRADATION; DRUG STABILITY; DRUG STORAGE;

EID: 0033022338     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991772024     Document Type: Article

References (8)

1. Bernasconi, R. (1965) Untersuchungen uber die Stabilitat von N,N-Dimethylenoxid-bis-(pyridinium-4-aldoxime)-dichloride in wasseriger Losung. Pharm. Acta Helv. 40: 564-574
2. Christenson, I. (1968a) Hydrolysis of bis(4-hydroxyiminomethyl-1-pyridiniomethyl)ether dichloride (Toxogonin) I. Decomposition products. Acta Pharm. Suecica 5: 23-36
3. Christenson, I. (1968b) Hydrolysis of bis(4-hydroxyiminomethyl-1-pyridiniomethyl)ether dichloride (Toxogonin) II. Kinetics and equilibrium in acidic solution. Acta Pharm. Suecica 5: 249-262
4. Christenson, I. (1972) Hydrolysis of obidoxime chloride (Toxogonin) III. Kinetics in neutral and alkaline solution. Acta Pharm. Suecica 9: 309-322
5. Connors, K. A., Amidon, G. L., Stella, V. J. (1979) Chemical Stability of Pharmaceuticals - A Handbook for Pharmacists, John Wiley & Sons, New York 86, p 23-26
6. Pohjola, J., Harpf, M. (1994) Determination of atropine and obidoxime in automatic injection devices used as antidotes against nerve agent intoxication. J. Chromatogr, A. 686: 350-354
7. Rubnov, S., Amisar, S., Levy, D., Muchtar, S., Schneider, H. (1999) Stability of trimedoxime (TMB-4) in concentrated acidic injectable solutions. Mil. Med. In press
8. Simonelli, A. P., Dresback, D. S. (1972) Principles of formulation of parenteral dosage forms. In: Francke, D. E., Whitney, H. A. K. (eds), Perspectives in Clinical Pharmacy, Drug Intelligence Publication, Hamilton, Illinois, Chapter 19